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Research article
Yuejun Huang
Second Affiliated Hospital of Shantou University Medical College
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8240-5738
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The effects of maternal antenatal corticosteroid (ACS) treatment, for fetal maturation, on the short-term outcome of late preterm infants are unclear.
Methods: This is a retrospective cohort study conducted in the Second Affiliated Hospital of Shantou University Medical College. Data of pregnant women who gave birth between 34 (0/7) to 36 (6/7) weeks gestation from January 2014 to June 2019 were collected. Nine short-term outcomes of preterm infants whose mother received ACS were compared to preterm infants whose mother did not receive ACS treatment.
Results: In total, 1393 pregnant women (of whom 757 accepted ACS treatment before delivery) and 1472 preterm infants were eligible for analysis. Administration of ACS to pregnant women at high risk for giving birth between 34 (0/7) to 36 (6/7) weeks pregnancy, was related to shorter hospital stay and less cost of preterm infants(slope was -0.784, P=0.026 and slope was -933.173, P=0.001, respectively).Lack of maternal ACS treatment was an independent risk factor for neonatal respiratory distress syndrome (RR=0.548, 95%CI=0.332～0.906).Use of maternal ACS did not increase risk of neonatal pneumonia, neonatal hypoglycemia, neonatal sepsis, necrotizing enterocolitis of newborns, neonatal intracranial hemorrhage, and hypoxic-ischemic encephalopathy in preterm infants.
Conclusions: Use of ACS for pregnant women at risk for giving birth between 34 (0/7) to 36 (6/7) weeks pregnancy hade more advantages than disadvantages of preterm infant short-term outcomes. Our study provides evidence-based medicine for clinicians to make ACS treatment choices for pregnant women with risk of giving birth between 34 (0/7) to 36(6/7) weeks gestation.
Keywords
antenatal corticosteroids; late preterm birth; short-term outcomes; preterm infants
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Yuejun Huang
Second Affiliated Hospital of Shantou University Medical College
Corresponding Author
ORCiD: https://orcid.org/0000-0001-8240-5738
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 3
Posted 15 Jan, 2021
No community comments so far
No comments provided
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The effects of maternal antenatal corticosteroid (ACS) treatment, for fetal maturation, on the short-term outcome of late preterm infants are unclear.
Methods: This is a retrospective cohort study conducted in the Second Affiliated Hospital of Shantou University Medical College. Data of pregnant women who gave birth between 34 (0/7) to 36 (6/7) weeks gestation from January 2014 to June 2019 were collected. Nine short-term outcomes of preterm infants whose mother received ACS were compared to preterm infants whose mother did not receive ACS treatment.
Results: In total, 1393 pregnant women (of whom 757 accepted ACS treatment before delivery) and 1472 preterm infants were eligible for analysis. Administration of ACS to pregnant women at high risk for giving birth between 34 (0/7) to 36 (6/7) weeks pregnancy, was related to shorter hospital stay and less cost of preterm infants(slope was -0.784, P=0.026 and slope was -933.173, P=0.001, respectively).Lack of maternal ACS treatment was an independent risk factor for neonatal respiratory distress syndrome (RR=0.548, 95%CI=0.332～0.906).Use of maternal ACS did not increase risk of neonatal pneumonia, neonatal hypoglycemia, neonatal sepsis, necrotizing enterocolitis of newborns, neonatal intracranial hemorrhage, and hypoxic-ischemic encephalopathy in preterm infants.
Conclusions: Use of ACS for pregnant women at risk for giving birth between 34 (0/7) to 36 (6/7) weeks pregnancy hade more advantages than disadvantages of preterm infant short-term outcomes. Our study provides evidence-based medicine for clinicians to make ACS treatment choices for pregnant women with risk of giving birth between 34 (0/7) to 36(6/7) weeks gestation.
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