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Research Article
H. A. Volk
University of Veterinary Medicine Hannover
Corresponding Author
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Background: Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5‑HT3 receptor antagonists to reduce nausea has been described for chemotherapy, but not for nausea secondary to vestibular disorders.
Methods: Sixteen dogs with vestibular syndrome-associated nausea were included in the open-label, multicentric study. The intensity of nausea-like behaviour was analysed before ondansetron administration (0.5 mg/kg i.v.) and 2 h afterwards, using a validated 5-point-scale. The occurrence and frequency of salivation, lip licking, restlessness, vocalisation, lethargy, and vomiting were assessed.
Results: All dogs initially showed signs of nausea, whereas only 31% showed vomitus. The intensity of nausea was significantly reduced in all dogs (p≤0.0001) 2 h after ondansetron administration, including the clinical signs of nausea analysed in 11 dogs (salivation [p=0.0078], lip licking [p=0.0078], restlessness [p=0.0039], and lethargy [p=0.0078]) except for vocalisation (p>0.9999).
Conclusion: The results provide preliminary evidence of the potential benefit of ondansetron in the treatment of nausea, which was present in all examined dogs. Vomiting was only observed in 5 dogs indicating that nausea can occur separately and should not be perceived only as a preceding stimulation of the vomiting centre.
Keywords
Vestibular syndrome, Ondansetron, Nausea, Behavioural Assessment
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No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
- additionaltable1.pdf
Title of data: Medical records of the included dogs with vestibular syndrome. Description of data: not applicable.
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Reviewer #13 agreed
On 30 Mar, 2021
Reviewer #5 agreed
On 30 Mar, 2021
Reviewer #6 agreed
On 30 Mar, 2021
Reviewer #12 agreed
On 30 Mar, 2021
Reviewer #1 agreed
On 30 Mar, 2021
Reviewer #11 agreed
On 30 Mar, 2021
Reviewer #7 agreed
On 30 Mar, 2021
Reviewers invited
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Editor invited
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This preprint is under consideration at BMC Veterinary Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
H. A. Volk
University of Veterinary Medicine Hannover
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Mar, 2021
No community comments so far
Reviewer #13 agreed
On 30 Mar, 2021
Reviewer #5 agreed
On 30 Mar, 2021
Reviewer #6 agreed
On 30 Mar, 2021
Reviewer #12 agreed
On 30 Mar, 2021
Reviewer #1 agreed
On 30 Mar, 2021
Reviewer #11 agreed
On 30 Mar, 2021
Reviewer #7 agreed
On 30 Mar, 2021
Reviewers invited
Invitations sent on 10 Mar, 2021
Editor assigned
On 10 Mar, 2021
Editor invited
On 01 Mar, 2021
Submission checks complete
On 01 Mar, 2021
First submitted
On 26 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Vestibular syndrome is often accompanied by nausea. Drugs currently approved for its treatment have been developed to stop vomiting but not nausea. The efficacy of 5‑HT3 receptor antagonists to reduce nausea has been described for chemotherapy, but not for nausea secondary to vestibular disorders.
Methods: Sixteen dogs with vestibular syndrome-associated nausea were included in the open-label, multicentric study. The intensity of nausea-like behaviour was analysed before ondansetron administration (0.5 mg/kg i.v.) and 2 h afterwards, using a validated 5-point-scale. The occurrence and frequency of salivation, lip licking, restlessness, vocalisation, lethargy, and vomiting were assessed.
Results: All dogs initially showed signs of nausea, whereas only 31% showed vomitus. The intensity of nausea was significantly reduced in all dogs (p≤0.0001) 2 h after ondansetron administration, including the clinical signs of nausea analysed in 11 dogs (salivation [p=0.0078], lip licking [p=0.0078], restlessness [p=0.0039], and lethargy [p=0.0078]) except for vocalisation (p>0.9999).
Conclusion: The results provide preliminary evidence of the potential benefit of ondansetron in the treatment of nausea, which was present in all examined dogs. Vomiting was only observed in 5 dogs indicating that nausea can occur separately and should not be perceived only as a preceding stimulation of the vomiting centre.
Figure 1
Figure 2
Figure 3
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