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Research article
Aihemaitijiang Yusufu
Xinjiang Medical University
Corresponding Author
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Background Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study was to determine the factors associated with the neural recovery of injured CPN in patients undergoing surgical exploration of CPN.
Methods This is a retrospective cohort study of all patients who underwent neural exploration for injured CPN from 2009 to 2019. A total of 387 patients with postoperative follow-up more than 12 months were included in the final analysis. We used univariate logistics regression analyses to assess which explanatory variables are associated with recovery of neurological function. We used multivariable logistic regression analysis to determine variables incorporated into clinical prediction model, developed a nomogram by the selected variables, and then assessed discrimination of the model by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.
Results There were 67 patients divided into case group and 320 patients divided into control group. In multivariate logistic regression analysis, we found that city area (OR = 3.35), labor occupation (OR = 4.39), diabetes (OR = 11.68), cardiovascular disease (OR = 51.35), knee joint dislocation (OR = 14.91), proximal fibula fracture (OR = 3.32), tibial plateau fracture (OR = 9.21), vascular injury (OR = 5.37) and hip arthroplasty (OR = 75.96) injury increased the risk of poor motor functional recovery of injured CPN, while high preoperative muscle strength (OR = 0.18) and postoperative knee joint immobilization (OR = 0.11) decreased this risk of injured CPN. AUC of the nomogram was 0.904 and 95% CI was 0.863–0.946.
Conclusions City area, labor occupation, diabetes, cardiovascular disease, knee joint dislocation, proximal fibula fracture, tibial plateau fracture, vascular injury and hip arthroplasty injury are independent risk factors of motor functional recovery of injured CPN, while high preoperative muscle strength and postoperative knee joint immobilization are protective factor of motor functional recovery of injured CPN. The prediction nomogram can be used to predict the prognosis of injured CPN.
Keywords
Common peroneal nerve injury, Nest case-control study, Prognostic risk factors
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CURRENT STATUS: Published
View the published article at BMC Surgery.
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Submission checks complete
On 25 Dec, 2020
Editorial decision: Accept
On 21 Dec, 2020
No comments provided
Review #2 received
Received 27 Nov, 2020
Review #1 received
Received 22 Nov, 2020
Reviewer #2 agreed
On 10 Nov, 2020
Editor assigned
On 09 Nov, 2020
Reviewers invited
Invitations sent on 09 Nov, 2020
Reviewer #1 agreed
On 09 Nov, 2020
Submission checks complete
On 09 Nov, 2020
Editor invited
On 09 Nov, 2020
Version 1
Posted 13 May, 2020
No comments provided
Editorial decision: Major revision
On 29 Oct, 2020
Review #3 received
Received 27 Oct, 2020
Reviewer #3 agreed
On 13 Oct, 2020
Review #2 received
Received 18 Sep, 2020
Reviewer #2 agreed
On 31 Aug, 2020
Review #1 received
Received 23 Jun, 2020
Reviewers invited
Invitations sent on 28 May, 2020
Reviewer #1 agreed
On 28 May, 2020
Editor assigned
On 06 May, 2020
Submission checks complete
On 05 May, 2020
Editor invited
On 05 May, 2020
First submitted
On 04 May, 2020
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A new preprint design is coming!
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See the published version of this preprint at BMC Surgery.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Aihemaitijiang Yusufu
Xinjiang Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Surgery.
No community comments so far
Submission checks complete
On 25 Dec, 2020
Editorial decision: Accept
On 21 Dec, 2020
No comments provided
Review #2 received
Received 27 Nov, 2020
Review #1 received
Received 22 Nov, 2020
Reviewer #2 agreed
On 10 Nov, 2020
Editor assigned
On 09 Nov, 2020
Reviewers invited
Invitations sent on 09 Nov, 2020
Reviewer #1 agreed
On 09 Nov, 2020
Submission checks complete
On 09 Nov, 2020
Editor invited
On 09 Nov, 2020
Version 1
Posted 13 May, 2020
No comments provided
Editorial decision: Major revision
On 29 Oct, 2020
Review #3 received
Received 27 Oct, 2020
Reviewer #3 agreed
On 13 Oct, 2020
Review #2 received
Received 18 Sep, 2020
Reviewer #2 agreed
On 31 Aug, 2020
Review #1 received
Received 23 Jun, 2020
Reviewers invited
Invitations sent on 28 May, 2020
Reviewer #1 agreed
On 28 May, 2020
Editor assigned
On 06 May, 2020
Submission checks complete
On 05 May, 2020
Editor invited
On 05 May, 2020
First submitted
On 04 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Surgery.
Background Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study was to determine the factors associated with the neural recovery of injured CPN in patients undergoing surgical exploration of CPN.
Methods This is a retrospective cohort study of all patients who underwent neural exploration for injured CPN from 2009 to 2019. A total of 387 patients with postoperative follow-up more than 12 months were included in the final analysis. We used univariate logistics regression analyses to assess which explanatory variables are associated with recovery of neurological function. We used multivariable logistic regression analysis to determine variables incorporated into clinical prediction model, developed a nomogram by the selected variables, and then assessed discrimination of the model by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.
Results There were 67 patients divided into case group and 320 patients divided into control group. In multivariate logistic regression analysis, we found that city area (OR = 3.35), labor occupation (OR = 4.39), diabetes (OR = 11.68), cardiovascular disease (OR = 51.35), knee joint dislocation (OR = 14.91), proximal fibula fracture (OR = 3.32), tibial plateau fracture (OR = 9.21), vascular injury (OR = 5.37) and hip arthroplasty (OR = 75.96) injury increased the risk of poor motor functional recovery of injured CPN, while high preoperative muscle strength (OR = 0.18) and postoperative knee joint immobilization (OR = 0.11) decreased this risk of injured CPN. AUC of the nomogram was 0.904 and 95% CI was 0.863–0.946.
Conclusions City area, labor occupation, diabetes, cardiovascular disease, knee joint dislocation, proximal fibula fracture, tibial plateau fracture, vascular injury and hip arthroplasty injury are independent risk factors of motor functional recovery of injured CPN, while high preoperative muscle strength and postoperative knee joint immobilization are protective factor of motor functional recovery of injured CPN. The prediction nomogram can be used to predict the prognosis of injured CPN.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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