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Research article
Wen-Sy Tsai MD
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6873-2863
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Laparoscopic surgery has achieved significant results in elderly patients with colorectal cancer (CRC). In this study, we compared the short-term and long-term outcomes of open surgery and laparoscopic surgery in patients with CRC aged above 75 years at a single tertiary medical center.
Methods: We analyzed 967 patients who underwent curative resection for primary colorectal adenocarcinoma without distant metastasis between January 2009 and December 2015, in a single institution. Of the enrolled patients, 305 underwent laparoscopic surgery, and 662 received open laparotomy surgery.
Results: Compared to the patients who underwent open surgery, those who received laparoscopic surgery had significantly shorter postoperative stay (10.3 vs. 13.5 days p < 0.001) and similar postoperative morbidity (p = 0.354) and mortality (p = 0.082). In the laparoscopy cohort, six of 305 patients were converted to open surgery and one died. The long-term overall survival, cancer-specific survival, and recurrence rate were similar between both cohorts in each stage.
Conclusions: Laparoscopic surgery is suitable for elderly patients owing to shorter postoperative stay, similar long-term outcomes with open surgery, and acceptable low conversion rates. For long-term overall and oncological outcomes, the results of laparoscopic surgery were similar to that of open surgery in each TNM stage.
Keywords
Colorectal cancer, Elderly, Laparoscopic surgery, Outcome
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CURRENT STATUS: Published
View the published article at BMC Surgery.
Version 3
Posted 24 Nov, 2020
No community comments so far
Submission checks complete
On 20 Nov, 2020
Editorial decision: Accept
On 16 Nov, 2020
No comments provided
Review #1 received
Received 23 Oct, 2020
Reviewer #1 agreed
On 20 Oct, 2020
Reviewers invited
Invitations sent on 20 Oct, 2020
Editor assigned
On 19 Oct, 2020
Submission checks complete
On 18 Oct, 2020
Editor invited
On 18 Oct, 2020
No comments provided
Editorial decision: Major revision
On 05 Oct, 2020
Review #2 received
Received 01 Oct, 2020
Reviewer #2 agreed
On 24 Sep, 2020
Review #1 received
Received 16 Jul, 2020
Reviewer #1 agreed
On 24 Jun, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Editor assigned
On 08 May, 2020
Submission checks complete
On 07 May, 2020
Editor invited
On 07 May, 2020
First submitted
On 06 May, 2020
Metrics
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PDF Downloads: ...
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Surgery.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Wen-Sy Tsai MD
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6873-2863
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Surgery.
Version 3
Posted 24 Nov, 2020
No community comments so far
Submission checks complete
On 20 Nov, 2020
Editorial decision: Accept
On 16 Nov, 2020
No comments provided
Review #1 received
Received 23 Oct, 2020
Reviewer #1 agreed
On 20 Oct, 2020
Reviewers invited
Invitations sent on 20 Oct, 2020
Editor assigned
On 19 Oct, 2020
Submission checks complete
On 18 Oct, 2020
Editor invited
On 18 Oct, 2020
No comments provided
Editorial decision: Major revision
On 05 Oct, 2020
Review #2 received
Received 01 Oct, 2020
Reviewer #2 agreed
On 24 Sep, 2020
Review #1 received
Received 16 Jul, 2020
Reviewer #1 agreed
On 24 Jun, 2020
Reviewers invited
Invitations sent on 18 May, 2020
Editor assigned
On 08 May, 2020
Submission checks complete
On 07 May, 2020
Editor invited
On 07 May, 2020
First submitted
On 06 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Surgery.
Background: Laparoscopic surgery has achieved significant results in elderly patients with colorectal cancer (CRC). In this study, we compared the short-term and long-term outcomes of open surgery and laparoscopic surgery in patients with CRC aged above 75 years at a single tertiary medical center.
Methods: We analyzed 967 patients who underwent curative resection for primary colorectal adenocarcinoma without distant metastasis between January 2009 and December 2015, in a single institution. Of the enrolled patients, 305 underwent laparoscopic surgery, and 662 received open laparotomy surgery.
Results: Compared to the patients who underwent open surgery, those who received laparoscopic surgery had significantly shorter postoperative stay (10.3 vs. 13.5 days p < 0.001) and similar postoperative morbidity (p = 0.354) and mortality (p = 0.082). In the laparoscopy cohort, six of 305 patients were converted to open surgery and one died. The long-term overall survival, cancer-specific survival, and recurrence rate were similar between both cohorts in each stage.
Conclusions: Laparoscopic surgery is suitable for elderly patients owing to shorter postoperative stay, similar long-term outcomes with open surgery, and acceptable low conversion rates. For long-term overall and oncological outcomes, the results of laparoscopic surgery were similar to that of open surgery in each TNM stage.
Figure 1
Figure 2
Figure 3
Figure 4
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