Elderly patients of mild cognitive impairment exhibit altered profiles of the gut microbiota
As the transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by cognitive decline greater than natural aging. While the association between AD and gut microbiota has been reported in a number of studies, there is still very limited microbial research about MCI.
Here we enrolled 48 participants, including 22 MCI cases and 26 normal controls. Fecal samples were collected for 16S rRNA quantitative arrays and bioinformatics analysis.
Both Principal Coordinates Analysis (PCoA) and Non-metric Multidimensional scaling (NMDS) demonstrated that the microbial composition of MCI individuals deviated from the cluster of healthy controls. Multiple bacterial species were significantly increased (e.g., Staphylococcus intermedius) or decreased (e.g., Bacteroides salyersiae) in the samples from MCI group.
Therefore, the composition of gut microbiota differed between control subjects and MCI cases. Our study is the first to identify a series of MCI signature species in the gut microbiota, thus providing a new direction for future development of early diagnosis and probiotics regimen.
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Posted 05 Jun, 2020
On 03 Jun, 2020
On 30 May, 2020
Elderly patients of mild cognitive impairment exhibit altered profiles of the gut microbiota
Posted 05 Jun, 2020
On 03 Jun, 2020
On 30 May, 2020
As the transitional state between normal aging and Alzheimer’s disease (AD), mild cognitive impairment (MCI) is characterized by cognitive decline greater than natural aging. While the association between AD and gut microbiota has been reported in a number of studies, there is still very limited microbial research about MCI.
Here we enrolled 48 participants, including 22 MCI cases and 26 normal controls. Fecal samples were collected for 16S rRNA quantitative arrays and bioinformatics analysis.
Both Principal Coordinates Analysis (PCoA) and Non-metric Multidimensional scaling (NMDS) demonstrated that the microbial composition of MCI individuals deviated from the cluster of healthy controls. Multiple bacterial species were significantly increased (e.g., Staphylococcus intermedius) or decreased (e.g., Bacteroides salyersiae) in the samples from MCI group.
Therefore, the composition of gut microbiota differed between control subjects and MCI cases. Our study is the first to identify a series of MCI signature species in the gut microbiota, thus providing a new direction for future development of early diagnosis and probiotics regimen.
Figure 1
Figure 2
Figure 3
Figure 4