Antibiotics are known to impact the bacteria in our gut microbiome, but their impact on gut fungi has been understudied. It is thought that antibiotics increase the fungal population by decreasing the competition from bacteria for nutrients. But a recent study found that the antibiotic amoxicillin-clavulanic acid has the opposite effect. By examining samples from mice and a small number of human infants, researchers found that this treatment triggered a decrease in intestinal fungi. The treatment also led to a total remodel of the fungal and bacterial population structures in the mouse gut microbiomes. Specifically, the fungal community gained a higher proportion of Aspergillus, Cladosporium, and Valsa groups, and the bacterial community had an increase in bacteria belonging to Enterobacteriaceae. Many Enterobacteriaceae reduce the fungal growth but among them E. hormaechei was particularly active in vitro and in vivo. The findings underscore how antibiotics impact the fungal microbiome community via disruptions in the bacterial community, and these new insights into gut bacterial-fungal interactions could lead to new strategies to control the gut microbiome equilibrium