This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Song Lin
Beijing Tiantan Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1760-1887
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: The conventional examination of molecular characteristics for glioma requires surgical removal and could not be used in the surgery planning. The aim is to develop a method previewing glioma malignancy with regular structural MRI images.
Methods: 52 glioma patients in frontal lobe (mean age 43.2±9.3 years, 34 male) and 117 healthy controls (mean age 32.6±9.8 years, 83 male) participated in the study. All patients underwent neurocognitive test and molecular examinations, including 1p/19q co-deletion, isocitrate dehydrogenase (IDH) mutation, telomerase reverse transcriptase (TERT) promoter mutation and O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation. A series of individual structural abnormality indexes based on preoperative structural MRI were proposed and explored the associations with these clinical indicators.
Results: Individual structural abnormality maps displayed that bilateral hippocampus, parahippocampus, insula, putamen and thalamus were constantly affected by glioma regardless of the histological grade, tumor hemisphere and molecular status. Higher grade glioma patients suffered more structural abnormalities, especially in the contralateral hemisphere and non-tumor regions. The molecular indicators, including IDH1 mutation, 1p/19q co-deletion, TERT promoter mutations and MGMT promoter methylation, as well as neurocognitive performance were all significantly correlated to individual structural abnormality indexes.
Conclusion: Our proposed individual structural abnormality indexes show great potentials to access the glioma pathological, neurocognitive and molecular indicators, which is very helpful for neurosurgeons to determine the personalized treatment strategies.
Keywords
glioma, structural MRI, individual structural abnormality index, molecular indicators, neurocognitive performance
Figure 1
Figure 2
Figure 3
Figure 4
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 12 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
Learn more about our company.
This is a preprint. It has not completed peer review.
Research Article
Song Lin
Beijing Tiantan Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1760-1887
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 12 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: The conventional examination of molecular characteristics for glioma requires surgical removal and could not be used in the surgery planning. The aim is to develop a method previewing glioma malignancy with regular structural MRI images.
Methods: 52 glioma patients in frontal lobe (mean age 43.2±9.3 years, 34 male) and 117 healthy controls (mean age 32.6±9.8 years, 83 male) participated in the study. All patients underwent neurocognitive test and molecular examinations, including 1p/19q co-deletion, isocitrate dehydrogenase (IDH) mutation, telomerase reverse transcriptase (TERT) promoter mutation and O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation. A series of individual structural abnormality indexes based on preoperative structural MRI were proposed and explored the associations with these clinical indicators.
Results: Individual structural abnormality maps displayed that bilateral hippocampus, parahippocampus, insula, putamen and thalamus were constantly affected by glioma regardless of the histological grade, tumor hemisphere and molecular status. Higher grade glioma patients suffered more structural abnormalities, especially in the contralateral hemisphere and non-tumor regions. The molecular indicators, including IDH1 mutation, 1p/19q co-deletion, TERT promoter mutations and MGMT promoter methylation, as well as neurocognitive performance were all significantly correlated to individual structural abnormality indexes.
Conclusion: Our proposed individual structural abnormality indexes show great potentials to access the glioma pathological, neurocognitive and molecular indicators, which is very helpful for neurosurgeons to determine the personalized treatment strategies.
Figure 1
Figure 2
Figure 3
Figure 4
Loading...