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Original investigation
Yu-jie Zhou
Capital Medical University Affiliated Anzhen Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9545-1984
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Cardiovascular Diabetology.
Background: The relationship between triglycerides-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index has a prognostic impact in patients with type 2 diabetes mellitus (T2DM) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).
Methods: The study retrospectively enrolled 798 patients (mean age: 60.9 ± 8.3 years; 68.3% men) with T2DM and NSTE-ACS who underwent PCI at Beijing Anzhen Hospital from January to December 2015. TyG index was calculated as previously reported: ln [fasting TGs (mg/dL) * FBG (mg/dL) / 2]. The primary endpoint was a composite of adverse events as follows: all-cause death, non-fatal myocardial infarction (MI) and ischemia-driven revascularization.
Results: TyG index were significantly higher in patients with a primary endpoint event compared with those without. Multivariate Cox analysis showed that 1-unit increase of TyG index was independently associated with higher risk of primary endpoint, independent of other risk factors [hazard ratio (HR) 3.208 per 1-unit increase, 95% confidence interval (CI) 2.400-4.289, P < 0.001]. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for adverse prognosis [AUC: baseline risk model, 0.800 vs. baseline risk model + TyG index, 0.856, P for comparison < 0.001; category-free net reclassification improvement (NRI) 0.346, P < 0.001; integrated discrimination improvement (IDI) 0.087, P < 0.001].
Conclusions: Increased TyG index is a significant predictor of adverse prognosis in patients with T2DM and NSTE-ACS undergoing PCI. Further studies need to be performed to determine whether interventions for TyG index have a positive impact on improving clinical prognosis.
Keywords
triglyceride glucose index, type 2 diabetes mellitus, non-ST-segment elevation acute coronary syndrome, percutaneous coronary intervention
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CURRENT STATUS: Published
Version 2
Posted 26 Jun, 2020
Published
On 08 Jul, 2020
No community comments so far
Editorial decision: Accept
On 28 Jun, 2020
Editor assigned
On 26 Jun, 2020
Submission checks complete
On 25 Jun, 2020
Editor invited
On 25 Jun, 2020
No comments provided
Reviewer #6 agreed
On 05 Jun, 2020
Review #6 received
Received 05 Jun, 2020
Editorial decision: Major Revision
On 05 Jun, 2020
Review #2 received
Received 26 May, 2020
Review #4 received
Received 26 May, 2020
Review #3 received
Received 26 May, 2020
Review #5 received
Received 26 May, 2020
Review #1 received
Received 25 May, 2020
Reviewers invited
Invitations sent on 17 May, 2020
Reviewer #1 agreed
On 17 May, 2020
Reviewer #2 agreed
On 17 May, 2020
Reviewer #3 agreed
On 17 May, 2020
Reviewer #4 agreed
On 17 May, 2020
Reviewer #5 agreed
On 17 May, 2020
Editor assigned
On 15 May, 2020
Submission checks complete
On 14 May, 2020
Editor invited
On 14 May, 2020
First submitted
On 12 May, 2020
Metrics
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PDF Downloads: ...
HTML Views: ...
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This preprint is under consideration at Cardiovascular Diabetology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Original investigation
Yu-jie Zhou
Capital Medical University Affiliated Anzhen Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9545-1984
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 26 Jun, 2020
Published
On 08 Jul, 2020
No community comments so far
Editorial decision: Accept
On 28 Jun, 2020
Editor assigned
On 26 Jun, 2020
Submission checks complete
On 25 Jun, 2020
Editor invited
On 25 Jun, 2020
No comments provided
Reviewer #6 agreed
On 05 Jun, 2020
Review #6 received
Received 05 Jun, 2020
Editorial decision: Major Revision
On 05 Jun, 2020
Review #2 received
Received 26 May, 2020
Review #4 received
Received 26 May, 2020
Review #3 received
Received 26 May, 2020
Review #5 received
Received 26 May, 2020
Review #1 received
Received 25 May, 2020
Reviewers invited
Invitations sent on 17 May, 2020
Reviewer #1 agreed
On 17 May, 2020
Reviewer #2 agreed
On 17 May, 2020
Reviewer #3 agreed
On 17 May, 2020
Reviewer #4 agreed
On 17 May, 2020
Reviewer #5 agreed
On 17 May, 2020
Editor assigned
On 15 May, 2020
Submission checks complete
On 14 May, 2020
Editor invited
On 14 May, 2020
First submitted
On 12 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Cardiovascular Diabetology.
Background: The relationship between triglycerides-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index has a prognostic impact in patients with type 2 diabetes mellitus (T2DM) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).
Methods: The study retrospectively enrolled 798 patients (mean age: 60.9 ± 8.3 years; 68.3% men) with T2DM and NSTE-ACS who underwent PCI at Beijing Anzhen Hospital from January to December 2015. TyG index was calculated as previously reported: ln [fasting TGs (mg/dL) * FBG (mg/dL) / 2]. The primary endpoint was a composite of adverse events as follows: all-cause death, non-fatal myocardial infarction (MI) and ischemia-driven revascularization.
Results: TyG index were significantly higher in patients with a primary endpoint event compared with those without. Multivariate Cox analysis showed that 1-unit increase of TyG index was independently associated with higher risk of primary endpoint, independent of other risk factors [hazard ratio (HR) 3.208 per 1-unit increase, 95% confidence interval (CI) 2.400-4.289, P < 0.001]. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for adverse prognosis [AUC: baseline risk model, 0.800 vs. baseline risk model + TyG index, 0.856, P for comparison < 0.001; category-free net reclassification improvement (NRI) 0.346, P < 0.001; integrated discrimination improvement (IDI) 0.087, P < 0.001].
Conclusions: Increased TyG index is a significant predictor of adverse prognosis in patients with T2DM and NSTE-ACS undergoing PCI. Further studies need to be performed to determine whether interventions for TyG index have a positive impact on improving clinical prognosis.
Figure 1
Figure 2
Figure 3
Figure 4
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