Certain parts of Odisha suffer from acute water scarcity at times due to nature's vagaries as well as improper management of water resources. Despite this, the groundwater situation, in general, does not appear to be very dire. Considering the above, an attempt has been made to perform hydrogeomorphic studies in two administrative blocks within Keonjhar District, Keonjhargarh and Patana. The study area extends between latitudes 21°26ꞌ38″N to 21°51ꞌ35″N and longitudes 85°37ꞌ6″E to 86°02ꞌ03″E with a total area of 1053.455 sq. Km. Survey of India Toposheets of 1:50,000 scale and LISS-III satellite data having a resolution of 30 meters are used to prepare several thematic layers, viz., lithological map, slope map, land-use and land cover map, lineament map and lineament density map, drainage map, and geomorphological map. The raster maps of these factors are assigned a fixed score and weight using the Multi Influencing Factor (MIF) technique. All the thematic layers have been integrated with one another in ArcGIS software to delineate groundwater potential zones using the weighted overlay analysis method. The final integrated layer has been classified into five classes, i.e., ‘Very Good,’ ‘Good,’ ‘Moderate,’ ‘Poor,’ and ‘Very Poor, to delineate groundwater potential zones that are validated using hydrological data. The present study has provided insight into the role played by geomorphological, lithological, climatological, and hydrogeological factors that affect the occurrence, distribution, movement, recharge-discharge, and quality of groundwater in the study area.