Table 2 Differentially expressed peptides in hUC-MSC conditioned medium from preterm and term infants
|
Accession
|
Gene
|
Protein
|
Petide
|
MW(kD)
|
Fold change
|
-10lgP
|
Up-regulated peptides
|
Q6PEZ8-3
|
PODNL1
|
Podocan-like protein 1
|
PSLERLHLQNNLISKVPR
|
5.94
|
∞
|
6.96
|
A0A0A0MTS7
|
TTN
|
Titin
|
ESDSG
|
2.92
|
13.62
|
9.66
|
Q9BYJ1-2
|
ALOXE3
|
Hydroperoxide isomerase ALOXE3
|
LNGRQQY
|
0.54
|
7.95
|
10.08
|
Q15772-1
|
SPEG
|
Striated muscle preferentially expressed protein kinase
|
SCTVAVARVPGKLAPPEVPQ
|
0.76
|
5.96
|
10.05
|
Q8N196
|
SIX5
|
Homeobox protein SIX5
|
AAAAGPANVH
|
1.00
|
5.93
|
11.82
|
P49815-3
|
TSC2
|
Tuberin
|
PAGPAVRL
|
0.57
|
4.52
|
10.67
|
A0A0A6YYA3
|
CDHR1
|
Cadherin-related family member 1
|
RVLRKRPSPAPRTIRIE
|
0.69
|
3.82
|
9.34
|
Q7Z5P9-2
|
MUC19
|
Mucin-19
|
DDFMSSQN
|
2.05
|
3.46
|
5.01
|
P54259
|
ATN1
|
Atrophin-1
|
GPARPYHP
|
0.67
|
3.28
|
11.27
|
A0A140TA73
|
SNTB2
|
Beta-2-syntrophin
|
NGLPNGGGAGDS
|
0.88
|
2.98
|
7.03
|
Q9UQD0-2
|
SCN8A
|
Sodium channel protein type 8 subunit alpha
|
EAGID
|
1.81
|
2.67
|
16.18
|
Q5TZA2-2
|
CROCC
|
Rootletin
|
RLLKGEASLEV
|
0.68
|
2.67
|
9.78
|
E7EMZ9
|
TACC2
|
Transforming acidic coiled-coil-containing protein 2
|
RMSESPTPC
|
1.29
|
2.57
|
8.92
|
A0A075B756
|
KLF14
|
Krueppel-like factor 14
|
TKHARRHP
|
0.94
|
2.52
|
17.50
|
A0A0A0MTS7
|
TTN
|
Titin
|
LEDGG
|
3.06
|
2.50
|
12.31
|
O15027-2
|
SEC16A
|
Protein transport protein Sec16A
|
KSILTQ
|
2.31
|
2.49
|
13.78
|
Q9NRA0-3
|
SPHK2
|
Sphingosine kinase 2
|
EWDGIVTVSGDGLLHEVLN
|
0.56
|
2.46
|
10.14
|
Q8WXG9
|
ADGRV1
|
Adhesion G-protein coupled receptor V1
|
EAGLD
|
2.02
|
2.23
|
19.57
|
Q9Y4D8
|
HECTD4
|
Probable E3 ubiquitin-protein ligase HECTD4
|
KLAKLQRIARQAVAALCALGG
|
1.02
|
2.21
|
6.58
|
A0A087WVF8
|
PDE4DIP
|
Myomegalin
|
QSMMAV
|
1.01
|
2.18
|
21.26
|
Q01167
|
FOXK2
|
Forkhead box protein K2
|
QTVHVVH
|
0.67
|
2.18
|
12.99
|
Q5IJ48
|
CRB2
|
Protein crumbs homolog 2
|
LLEVAVPAACACLLLLLLGLLSGILAARK
|
0.78
|
2.18
|
5.08
|
Q9ULE3
|
DENND2A
|
DENN domain-containing protein 2A
|
FLHKK
|
1.70
|
2.17
|
21.46
|
P53420
|
COL4A4
|
Collagen alpha-4(IV) chain
|
PGEPGLVGPPGQPGRPG
|
0.84
|
2.14
|
7.51
|
Q7Z5P9-2
|
MUC19
|
Mucin-19
|
FLGGS
|
2.11
|
2.11
|
13.79
|
P01833
|
PIGR
|
Polymeric immunoglobulin receptor
|
QADGSRASVD
|
0.49
|
2.10
|
5.11
|
Q09666
|
AHNAK
|
Neuroblast differentiation-associated protein AHNAK
|
KLKGDI
|
1.57
|
2.08
|
15.35
|
P36776
|
LONP1
|
Lon protease homolog, mitochondrial
|
KHKPR
|
0.99
|
2.07
|
8.69
|
A0A0A0MTS7
|
TTN
|
Titin
|
VPEAPKEVVPEKKVPVTPPKK
|
2.94
|
1.98
|
10.42
|
Q8NEZ4
|
KMT2C
|
Histone-lysine N-methyltransferase 2C
|
QQNNLSNP
|
1.03
|
1.96
|
10.44
|
A0A0A0MTS7
|
TTN
|
Titin
|
SPPSP
|
2.94
|
1.93
|
11.70
|
Q7Z5P9-2
|
MUC19
|
Mucin-19
|
AGTSI
|
2.24
|
1.89
|
23.15
|
O75592-2
|
MYCBP2
|
E3 ubiquitin-protein ligase MYCBP2
|
QLLYR
|
2.05
|
1.79
|
11.10
|
Q9H6K5-2
|
PRR36
|
Proline-rich protein 36
|
PPSLQTLPSPPATPPSQVPPTQ
|
0.81
|
1.78
|
9.94
|
P08913
|
ADRA2A
|
Alpha-2A adrenergic receptor
|
ISAVISFPPLISIEKKGGGG
|
0.93
|
1.71
|
9.59
|
Q9UJ55
|
MAGEL2
|
MAGE-like protein 2
|
PPPIRPGP
|
1.10
|
1.65
|
15.90
|
Q4V328-4
|
GRIPAP1
|
GRIP1-associated protein 1
|
LCSQMEQLE
|
0.63
|
1.60
|
6.91
|
Down-regulated peptides
|
|
|
|
|
|
|
O14526-3
|
FCHO1
|
F-BAR domain only protein 1
|
AGIVRVF
|
0.53
|
-1.56
|
9.90
|
Q7Z5P9-2
|
MUC19
|
Mucin-19
|
KTLAAGS
|
2.15
|
-1.57
|
14.06
|
Q99814
|
EPAS1
|
Endothelial PAS domain-containing protein 1
|
TPLSSMGGRS
|
1.00
|
-1.58
|
18.34
|
Q6ZNL6
|
FGD5
|
FYVE, RhoGEF and PH domain-containing protein 5
|
EDHAQ
|
0.77
|
-1.58
|
13.24
|
Q9BW04-2
|
SARG
|
Specifically androgen-regulated gene protein
|
LTTPKPRKLPPN
|
0.61
|
-1.60
|
5.40
|
O15027-2
|
SEC16A
|
Protein transport protein Sec16A
|
QACAASGS
|
2.41
|
-1.61
|
17.59
|
S4R393
|
ZSWIM8
|
Zinc finger SWIM domain-containing protein 8
|
QTHKPQT
|
0.99
|
-1.64
|
13.03
|
Q2VWA4
|
SKOR2
|
SKI family transcriptional corepressor 2
|
GGSGGDCSAG
|
0.50
|
-1.65
|
8.13
|
Q9Y6V0-6
|
PCLO
|
Protein piccolo
|
QQPGPAKPPP
|
1.00
|
-1.69
|
6.21
|
P28329
|
CHAT
|
Choline O-acetyltransferase
|
GLPKLPVPPLQQ
|
0.66
|
-1.70
|
5.12
|
Q8WXH0
|
SYNE2
|
Nesprin-2
|
KIYKKFLKKAQDLTSLLKEL
|
2.04
|
-1.71
|
5.55
|
P13611-5
|
VCAN
|
Versican core protein
|
QPEFSS
|
1.97
|
-1.74
|
29.72
|
Q8TE85
|
GRHL3
|
Grainyhead-like protein 3 homolog
|
LFIPNVHFSSLQRSG
|
0.54
|
-1.78
|
9.85
|
A0A1B0GUF7
|
IQCM
|
IQ domain-containing protein M
|
KTFKT
|
0.88
|
-1.79
|
14.67
|
A0A087WXW9
|
COL5A1
|
Collagen alpha-1(V) chain
|
PPGEV
|
2.70
|
-1.83
|
8.75
|
A0A0A0MTS7
|
TTN
|
Titin
|
KACDPVF
|
2.92
|
-1.87
|
8.46
|
A0A0A0MTS7
|
TTN
|
Titin
|
IVASDVTKRLIKANLLANN
|
2.78
|
-1.87
|
5.62
|
H0Y5I7
|
SFI1
|
Protein SFI1 homolog
|
QQLAARRQEQRATVRALW
|
0.82
|
-1.88
|
6.99
|
A6NMZ7
|
COL6A6
|
Collagen alpha-6(VI) chain
|
RRAIN
|
0.91
|
-1.89
|
13.43
|
Q8NEZ4
|
KMT2C
|
Histone-lysine N-methyltransferase 2C
|
EGCVK
|
1.08
|
-1.89
|
12.10
|
A0A087WXW9
|
COL5A1
|
Collagen alpha-1(V) chain
|
GPRGITGKPGPK
|
2.70
|
-1.90
|
10.79
|
Q9Y6W6
|
DUSP10
|
Dual specificity protein phosphatase 10
|
DNQAQT
|
1.21
|
-1.91
|
9.85
|
A0A0J9YXV3
|
N/A
|
Uncharacterized protein
|
KIGLGY
|
0.94
|
-1.91
|
14.05
|
A0A0A0MTS7
|
TTN
|
Titin
|
EGNKDD
|
3.08
|
-1.91
|
12.34
|
Q92616
|
GCN1
|
eIF-2-alpha kinase activator GCN1
|
ILDVASLEVLN
|
0.66
|
-1.92
|
5.74
|
Q9NR09
|
BIRC6
|
Baculoviral IAP repeat-containing protein 6
|
DNESCTN
|
1.47
|
-1.95
|
6.90
|
Q8TEP8
|
CEP192
|
Centrosomal protein of 192 kDa
|
LLSTTK
|
1.70
|
-1.96
|
17.83
|
A0A0A0MTS7
|
TTN
|
Titin
|
DPPGKPVPLN
|
3.22
|
-2.08
|
14.35
|
Q8TE73
|
DNAH5
|
Dynein heavy chain 5, axonemal
|
QRVKSKIPAAIEQLIVPHLAKVDEALQPGLAAL
|
1.84
|
-2.10
|
7.15
|
P10827-4
|
THRA
|
Thyroid hormone receptor alpha
|
LHARAV
|
0.51
|
-2.11
|
9.87
|
Q9P2D3
|
HEATR5B
|
HEAT repeat-containing protein 5B
|
HAKGK
|
0.83
|
-2.12
|
12.50
|
O60423-3
|
ATP8B3
|
Phospholipid-transporting ATPase IK
|
YGLVI
|
0.98
|
-2.13
|
11.77
|
P06401-2
|
PGR
|
Progesterone receptor
|
GPLLKGKPRALGGAAAGGG
|
0.77
|
-2.14
|
5.47
|
A0A140T8Y3
|
TNXB
|
Tenascin-X
|
HGRGRCEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQ
|
1.71
|
-2.14
|
5.92
|
P27658
|
COL8A1
|
Collagen alpha-1(VIII) chain
|
GIDGVKPPHAYGAKKGKN
|
0.65
|
-2.14
|
6.82
|
Q9C093
|
SPEF2
|
Sperm flagellar protein 2
|
ESLCEKVKEILTTEIAKKKN
|
0.69
|
-2.14
|
7.26
|
Q8NAC3-3
|
IL17RC
|
Interleukin-17 receptor C
|
AAALSLILLLKKDHAKGWLRLLKQ
|
0.48
|
-2.15
|
5.00
|
Q92771
|
DDX12P
|
Putative ATP-dependent RNA helicase DDX12
|
KGGLLGRLAARKKIFQEPK
|
0.67
|
-2.16
|
6.09
|
Q6PJG9
|
LRFN4
|
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
|
VAVGGVLVAALLVFTVALLVRGRGAGNGRL
|
0.69
|
-2.17
|
5.32
|
Q9HD67
|
MYO10
|
Unconventional myosin-X
|
KTSCVE
|
0.82
|
-2.23
|
14.68
|
Q96DN2
|
VWCE
|
von Willebrand factor C and EGF domain-containing protein
|
RPVLHLLQLLLRTNLMKTQTL
|
0.50
|
-2.26
|
9.34
|
Q96QD8
|
SLC38A2
|
Sodium-coupled neutral amino acid transporter 2
|
VFNLSNAIVGSGILGLS
|
0.60
|
-2.31
|
12.68
|
A0A0C4DGG6
|
NPC1L1
|
NPC1-like intracellular cholesterol transporter 1
|
VFAVVTILLVGFRVAPARDKSKMVDPKK
|
0.68
|
-2.32
|
12.53
|
Q9UQD0-2
|
SCN8A
|
Sodium channel protein type 8 subunit alpha
|
VSLVSLIAN
|
1.71
|
-2.33
|
12.11
|
Q9UPA5
|
BSN
|
Protein bassoon
|
KGGPRPR
|
2.05
|
-2.34
|
10.76
|
Q9UKV8
|
AGO2
|
Protein argonaute-2
|
KLQAN
|
1.17
|
-2.36
|
13.86
|
Q9UQD0-2
|
SCN8A
|
Sodium channel protein type 8 subunit alpha
|
YLALL
|
1.72
|
-2.36
|
14.90
|
I6L894
|
ANK2
|
Ankyrin-2
|
KHKLNVP
|
0.89
|
-2.38
|
11.67
|
O95996
|
APC2
|
Adenomatous polyposis coli protein 2
|
PAAEAATKKPLPPLRH
|
0.78
|
-2.39
|
5.35
|
P36776
|
LONP1
|
Lon protease homolog, mitochondrial
|
TIAAKRAGVT
|
0.99
|
-2.46
|
12.42
|
H7BXZ5
|
KALRN
|
Kalirin
|
VKKCIHKATRKDVAVKFVSKKMKKKEQA
|
0.91
|
-2.46
|
9.58
|
Q8NF91-4
|
SYNE1
|
Nesprin-1
|
QKAVDHRKAIILSIN
|
1.02
|
-2.56
|
8.45
|
J3KQC6
|
TMPRSS13
|
Transmembrane protease serine 13
|
LPLIGCVLLLIALVVSLIILFQFW
|
0.45
|
-2.60
|
5.00
|
Q8TE73
|
DNAH5
|
Dynein heavy chain 5, axonemal
|
AQTKRLVGDVLLATAFLSYSGP
|
1.82
|
-2.62
|
5.48
|
I3L2R4
|
SLC2A4
|
Solute carrier family 2 (Facilitated glucose transporter), member 4, isoform CRA_b
|
IGAGVVNTVFTLVSVLLVERAGRRTLHLLGLA
|
0.62
|
-2.63
|
7.43
|
P42167
|
TMPO
|
Lamina-associated polypeptide 2, isoforms beta/gamma
|
KSEKTKKGRSIPVWIKILLFVVVAV
|
0.49
|
-2.66
|
6.27
|
Q9BW11-4
|
MXD3
|
Max dimerization protein 3
|
GPIHRRK
|
0.50
|
-2.66
|
7.43
|
E7EPG1
|
MMRN1
|
Multimerin-1
|
LPDIQLLQKGLTEFV
|
0.66
|
-2.70
|
6.46
|
G5EA42
|
TMOD2
|
Tropomodulin 2 (Neuronal), isoform CRA_a
|
HVKKF
|
0.67
|
-2.76
|
12.93
|
A0A0A0MTS7
|
TTN
|
Titin
|
SSRLECKI
|
2.84
|
-2.77
|
7.13
|
Q7Z5P9-2
|
MUC19
|
Mucin-19
|
QNGIIVI
|
2.18
|
-2.78
|
18.23
|
Q5H8A4
|
PIGG
|
GPI ethanolamine phosphate transferase 2
|
WLAAGGVMVLASALLCVIVSVLTNVLVGGN
|
1.18
|
-2.80
|
9.72
|
Q9NR09
|
BIRC6
|
Baculoviral IAP repeat-containing protein 6
|
TRIGLKLIDILLRNCAAS
|
1.36
|
-2.82
|
5.14
|
A0A0A0MTS7
|
TTN
|
Titin
|
VVHAGGVIRIIAYV
|
2.83
|
-2.89
|
5.92
|
Q8NG04
|
SLC26A10
|
Solute carrier family 26 member 10
|
EPVVKALTSGAALHVLLSQLPSLLGLSL
|
0.59
|
-2.91
|
11.40
|
J3KNF3
|
TET3
|
Methylcytosine dioxygenase TET3
|
GPEGCSA
|
1.65
|
-2.94
|
15.44
|
Q92835-2
|
INPP5D
|
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
|
PLPVKSPA
|
1.01
|
-2.97
|
22.11
|
Q9Y6R1
|
SLC4A4
|
Electrogenic sodium bicarbonate cotransporter 1
|
HHTIYIGVHVPKSYR
|
0.78
|
-2.99
|
8.24
|
Q99707
|
MTR
|
Methionine synthase
|
KSARVMKKAVG
|
1.66
|
-3.12
|
21.33
|
Q8WXG9
|
ADGRV1
|
Adhesion G-protein coupled receptor V1
|
RFLQSIYLVPEEDHILIIPVVRGKDN
|
1.97
|
-3.13
|
8.73
|
P43243-2
|
MATR3
|
Matrin-3
|
HLILN
|
0.67
|
-3.21
|
8.71
|
O75970-3
|
MPDZ
|
Multiple PDZ domain protein
|
FISLLKT
|
0.58
|
-3.22
|
11.08
|
Q96N23-2
|
CFAP54
|
Cilia- and flagella-associated protein 54
|
HLKKPKIKISGSPLTLKPPLRRSSSVKET
|
0.62
|
-3.25
|
6.96
|
F8WBW8
|
BAHCC1
|
BAH and coiled-coil domain-containing protein 1
|
RSVKAKVGTTL
|
1.16
|
-3.27
|
15.77
|
F8VZY0
|
MYBPC1
|
Myosin-binding protein C, slow-type
|
TDAKIFVRVKAVNAAGAS
|
0.76
|
-3.39
|
9.25
|
G0XQ39
|
STIM1
|
STIM1L
|
GVHPGSLVEKLPDSPALAKKALLALNHGL
|
0.59
|
-3.56
|
12.45
|
P0CJ78
|
ZNF865
|
Zinc finger protein 865
|
MEANPAGSGAGGGGSSGIGGEDGVHFQSYPFDFLEFLNHQRFEPMELYGEHAKAVAA
|
0.86
|
-3.84
|
11.26
|
Q7LBC6-2
|
KDM3B
|
Lysine-specific demethylase 3B
|
VKSKASLPN
|
0.69
|
-3.87
|
7.94
|
Q9UI33-3
|
SCN11A
|
Sodium channel protein type 11 subunit alpha
|
IGAIPAILNV
|
0.83
|
-4.13
|
15.16
|
Q5XPI4
|
RNF123
|
E3 ubiquitin-protein ligase RNF123
|
HYLRLTIAI
|
0.67
|
-4.16
|
8.06
|
O15027-2
|
SEC16A
|
Protein transport protein Sec16A
|
AGSLCQALLPGPSNEAAGDVWGDTASTGVPDASGSQYE
|
2.30
|
-4.48
|
5.51
|
B7ZLJ5
|
MPIG6B
|
C6orf25 protein
|
YPQLLIPLLGAGLVLGLGALG
|
0.48
|
-4.66
|
5.03
|
Q86WI1
|
PKHD1L1
|
Fibrocystin-L
|
LFVGR
|
1.16
|
-4.97
|
17.10
|
Q7Z3U7
|
MON2
|
Protein MON2 homolog
|
KPPQYGQLETKHIAN
|
1.01
|
-5.28
|
21.73
|
F1T0I1
|
SEC16A
|
Protein transport protein sec16
|
RRRAN
|
2.30
|
-5.79
|
11.96
|
A0A087WXW9
|
COL5A1
|
Collagen alpha-1(V) chain
|
HPGLI
|
2.50
|
-5.82
|
5.85
|
Q9H3S7
|
PTPN23
|
Tyrosine-protein phosphatase non-receptor type 23
|
KLELLRQN
|
0.65
|
-6.11
|
5.79
|
Q7Z5P9-2
|
MUC19
|
Mucin-19
|
TGAKIKLVGT
|
2.11
|
-6.37
|
6.06
|
P52746
|
ZNF142
|
Zinc finger protein 142
|
TGLKP
|
4.94
|
-∞
|
13.46
|
P43088-7
|
PTGFR
|
Prostaglandin F2-alpha receptor
|
QKSKASFLL
|
3.34
|
-∞
|
9.46
|
A0A1C7CYW7
|
TTC34
|
Tetratricopeptide repeat protein 34
|
TGGQRLLAAL
|
3.68
|
-∞
|
12.39
|
Q9Y219
|
JAG2
|
Protein jagged-2
|
CGSDAGPGMPGTAASGVCGPHGRCVSQPGGN
|
3.52
|
-∞
|
10.83
|
E7ERG8
|
LRP1B
|
Low-density lipoprotein receptor-related protein 1B
|
QVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLT
|
3.26
|
-∞
|
5.58
|
O75129-2
|
ASTN2
|
Astrotactin-2
|
TCHLC
|
5.80
|
-∞
|
12.93
|