[1] Csuka D, Veszeli N, Varga L, Prohászka Z, Farkas H. The role of the complement system in hereditary angioedema. Mol Immunol. 2017 Sep; 89:59-68.
[2] Bork, K., Meng, G., Staubach, P., Hardt, J. Hereditary angioedema: new findings concerning symptoms, affected organs, and course. Am J Med. 2006 Mar;119(3):267-74.
[3] d'Apolito M, Santacroce R, Colia AL, Cordisco G, Maffione AB, Margaglione M. Angiopoietin‐1 haploinsufficiency affects the endothelial barrier and causes hereditary angioedema. Clin Exp Allergy. 2019 May;49(5):626-635.
[4] de Maat S, Björkqvist J, Suffritti C, Wiesenekker CP, Nagtegaal W, Koekman A, et al. Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations. J Allergy Clin Immunol. 2016 Nov;138(5):1414-1423.e9.
[5] Belbézier A, Hardy G, Marlu R, Defendi F, Dumestre Perard C, Boccon-Gibod I, et al. Plasminogen gene mutation with normal C1 inhibitor hereditary angioedema: Three additional French families. Allergy. 2018 Nov;73(11):2237-2239.
[6] Liu S, Xu Y, Liu Y, Zhi Y. Hereditary angioedema: a Chinese perspective. Eur J Dermatol. 2019 Feb 1;29(1):14-20.
[7] Zanichelli A, Magerl M, Longhurst H, Fabien V, Maurer M. Hereditary angioedema with C1 inhibitor deficiency: delay in diagnosis in Europe. Allergy Asthma Clin Immunol. 2013 Aug 12;9(1):29.
[8] Jolles S, Williams P, Carne E, Mian H, Huissoon A, Wong G, et al. A UK national audit of hereditary and acquired angioedema. Clin Exp Immunol. 2014 Jan;175(1):59-67.
[9] Christiansen SC, Davis DK, Castaldo AJ, Zuraw BL. Pediatric hereditary angioedema: onset: diagnostic delay, and disease severity. Clin Pediatr (Phila). 2016; 55:935–942.
[10] Xu YY, Jiang Y, Zhi YX, Yin J, Wang LL, Wen LP et al. Clinical features of hereditary angioedema in Chinese patients: new findings and differences from other populations. Eur J Dermatol. 2013 Jul-Aug;23(4):500-4.
[11] Bork K, Meng G, Staubach P, Hardt J. Hereditary angioedema: new findings concerning symptoms, affected organs, and course. Am J Med. 2006; 119:267–274.
[12] Zanichelli A, Vacchini R, Badini M, Penna V, Cicardi M. Standard care impact on angioedema because of hereditary C1 inhibitor deficiency: a 21-month prospective study in a cohort of 103 patients. Allergy. 2011; 66:192–196.
[13] Bork K, Hardt J, Witzke G. Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency. J Allergy Clin Immunol. 2012; 130:692–697.
[14] Liu S, Wang X, Xu Y, Xu Q, Zhi Y. Risk factors for diagnostic delay in Chinese patients with hereditary angioedema. Allergy Asthma Proc. 2019 Sep 1;40(5):343-349.
[15] Bruce L. Zuraw, M.D. Hereditary Angioedema. N Engl J Med 2008; 359:1027-1036.
[16] Konrad Bork, Anette Bygum, Jochen Hardt. Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. Ann Allergy Asthma Immunol. 2008 Feb; 100(2):153-61.
[17] Sierra F, Coeytaux S, Juillerat M, Ruffieux C, Gauldie J, Guigoz Y. Serum T-kininogen levels increase two to four months before death. J Biol Chem. 1992; 267:10665–10669.
[18] Sierra F. Both T and K-kininogens increase in the serum of old rats, but by different mechanisms. Mech Ageing Dev. 1995; 84:127–137.
[19] Kleniewsky J, Czokalo M. Plasma kininogen concentration: the low level in cord blood plasma and age dependence in adults. Eur J Haematol. 1991 May; 46(5):257-62.
[20] Pérez V, Velarde V, Acuña-Castillo C, Gómez C, Nishimura S, Sabaj V, et al. Increased Kinin Levels and Decreased Responsiveness to Kinins During Aging. J Gerontol A Biol Sci Med Sci. 2005 Aug; 60(8):984-90.
[21] Kintsurashvili E, Duka A, Ignjacev I, Pattakos G, Gavras I, Gavras H. Age-related changes of bradykinin B1 and B2 receptors in rat heart. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H202-5.
[22] Nurmi L, Heikkila HM, Vapaatalo H, Kovanen PT, Lindstedt KA. Downregulation of bradykinin type 2 receptor expression in cardiac endothelial cells during senescence. J Vasc Res. 2012; 49: 13-23.
[23] Sang H, Liu L, Wang L, et al. Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats. Eur J Neurosci. 2016; 43: 53-65.
[24] Siltari A, Roivanen J, Korpela R, Vapaatalo H. Long-term feeding with bioactive tripeptides in aged hypertensive and normotensive rats: special focus on blood pressure and bradykinin-induced vascular reactivity. J Physiol Pharmacol. 2017 Jun;68(3):407-418.
[25] Bork K, Meng G, Staubach P, Hardt J. Hereditary Angioedema: New Findings Concerning Symptoms, Affected Organs, and Course. Am J Med. 2006 Mar;119(3):267-74.
[26] B.Zuraw, S. Christiansen. HAE Pathophysiology and Underlying Mechanisms. Clin Rev Allergy Immunol. 2016 Oct;51(2):216-29.
[27] Bouillet L, Longhurst H, Boccon-Gibod I, Bork K, Bucher C, Bygum A, et al. Disease expression in women with hereditary angioedema. Am J Obstet Gynecol. 2008 Nov; 199(5): 484. e1-4.
[28] Chen LM, Chung P, Chao S, Chao L, Chao J. Differential regulation of kininogen gene ex- pression by estrogen and progesterone in vivo. Biochim Biophys Acta 1992; 1131: 145-51.
[29] Joseph K, Tholanikunnel BG, Kaplan AP. Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema. J Allergy Clin Immunol. 2017 Jul;140(1):170-176.
[30] Madeddu P, Emanueli C, Song Q, Varoni MV, Demontis MP, Anania V, et al. Regulation of bradykinin B2-receptor expression by oestrogen. Br J Pharmacol 1997; 121: 1763-9.
[31] Baram M, Kommuri A, Sellers SA, Cohn JR. ACE Inhibitor–Induced Angioedema. J Allergy Clin Immunol Pract. 2013 Sep-Oct;1(5):442-5.
[32] Bukowska A, Spiller L, Wolke C, Lendeckel U, Weinert S, Hoffmann J, et al. Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men. Exp Biol Med (Maywood). 2017 Aug;242(14):1412-1423.
[33] Urs C. Steiner, Lea Kölliker, Christina Weber-Chrysochoou, Peter Schmid-Grendelmeier, Elsbeth Probst, Walter A. Wuillemin, et al. Food as a trigger for abdominal angioedema attacks in patients with hereditary angioedema. Orphanet J Rare Dis. 2018; 13: 90.
[34] Tanaka Y, Yamashita Y. Effects of ethanol administration at a high-dose level on the stimulatory action by bradykinin in vascular permeability. J Nutr Sci Vitaminol (Tokyo) 2002; 48:270–277.
[35] Nettleton JA, Steffen LM, Mayer-Davis EJ, Jenny NS, Jiang R, Herrington DM, et al. Patterns are associated with biochemical markers of inflammation and endothelial activation in the Multi-Ethnic Study of Atherosclerosis (MESA) Am J Clin Nutr. 2006;83(6):1369–1379.
[36] Michael M. Chen, Eileen B. O’Halloran, Jill A. Ippolito, Mashkoor A. Choudhry, Elizabeth J. Kovacs. Alcohol potentiates post burn remote organ damage through shifts in fluid compartments mediated by bradykinin. Shock. 2015 Jan; 43(1): 80–84.
[37] Tanaka A1, Cui R, Kitamura A, Liu K, Imano H, Yamagishi K, et al. Heavy Alcohol Consumption is Associated with Impaired Endothelial Function. J Atheroscler Thromb. 2016 Sep 1;23(9):1047-54.
[38] Oda N, Kajikawa M, Maruhashi T, Iwamoto Y, Kishimoto S, Matsui S, et al. Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study. Int J Cardiol. 2017 Mar 1;230:523-528.
[39] Vanhoutte PM, Shimokawa H, Feletou M, Tang EH. Endothelial dysfunction and vascular disease - a 30th anniversary update. Acta Physiol (Oxf). 2017 Jan;219(1):22-96.
[40] Anette Bygum, Paula Busse, Teresa Caballero, Marcus Maurer. Disease Severity, Activity, Impact, and Control and How to Assess Them in Patients with Hereditary Angioedema. Front. Med.2017 December.4:212.