Overconsumption of food is one factor linked to obesity. In certain individuals, the pleasure experienced from food rewards may override signals indicating “I’m full.” One possible influencer in this process is the gut microbiome. The composition of the gut microbiota is known to be unbalanced in obesity. But how it contributes to further dysregulating eating behaviors via the food reward system is poorly understood. To assess the role of the gut microbiota in food intake regulation, researchers transferred gut-microbe-containing fecal material from obese donor mice into lean recipient mice. Experiments revealed that recipient mice developed excessive motivation for a food reward and that the gut microbes from obese donor mice altered the brain reward system of recipient mice. Motivation for food rewards was associated with changes in gut microbe-produced metabolites. with the metabolite 33HPP being identified as a modulator of neurotransmitter signalling. While this study identified novel therapeutic targets for excessive food intake motivation, more work is needed to understand how to best modulate these targets to prevent compulsive eating and address obesity.