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Research Article
Yongliang Chu
Zhuhai Hospital of Guangdong Chinese Medicine
Corresponding Author
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Background. To explore the prevalence of bone loss among patients with rheumatoid arthritis and healthy controls and further explored the risk factors for osteopenia and osteoporosis of RA patients.
Methods. A cross-sectional survey was undertaken in four hospitals in different districts in South China. Case records, laboratory tests, and bone mineral density (BMD) results were included. Multivariable logistic regression analysis, least absolute shrinkage, selection operator (LASSO), and random forest (RF) was for exploring the risk factors for osteopenia or osteoporosis in RA patients.
Results. Four hundred five patients with RA and 198 HC were included. RA patients had lower BMD in almost detective sites than healthy controls; the decline of lumbar spine BMD was earlier than HC. RA patients were more likely to comorbid with osteopenia and osteoporosis (p for trend <0.001) in the lumbar spine than HC. Higher serum 25-hydroxyvitamin D3 level and using tumor necrosis factor inhibitor in the last year, aging, lower body mass index, and increased serum uric acid were associated with bone loss.
Conclusions. RA patients were more prone and earlier to have bone loss than HC. More attention should be paid to measuring BMD in RA patients aging with lower BMI or hyperuricemia. Besides, serum vitamin D and all three detective sites are recommended to check routinely. TNFi usage in the last year might benefit bone mass.
Keywords
Arthritis, Rheumatoid, Osteoporosis, Prevalence, Risk Factor
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No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 16 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 08 Apr, 2021
Reviews received
Received 26 Mar, 2021
Reviewers agreed
On 19 Mar, 2021
Reviewers invited
Invitations sent on 15 Mar, 2021
Editor assigned
On 15 Mar, 2021
Editor invited
On 15 Mar, 2021
Submission checks complete
On 15 Mar, 2021
First submitted
On 02 Mar, 2021
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A new preprint design is coming!
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This preprint is under consideration at BMC Musculoskeletal Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yongliang Chu
Zhuhai Hospital of Guangdong Chinese Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 16 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 08 Apr, 2021
Reviews received
Received 26 Mar, 2021
Reviewers agreed
On 19 Mar, 2021
Reviewers invited
Invitations sent on 15 Mar, 2021
Editor assigned
On 15 Mar, 2021
Editor invited
On 15 Mar, 2021
Submission checks complete
On 15 Mar, 2021
First submitted
On 02 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background. To explore the prevalence of bone loss among patients with rheumatoid arthritis and healthy controls and further explored the risk factors for osteopenia and osteoporosis of RA patients.
Methods. A cross-sectional survey was undertaken in four hospitals in different districts in South China. Case records, laboratory tests, and bone mineral density (BMD) results were included. Multivariable logistic regression analysis, least absolute shrinkage, selection operator (LASSO), and random forest (RF) was for exploring the risk factors for osteopenia or osteoporosis in RA patients.
Results. Four hundred five patients with RA and 198 HC were included. RA patients had lower BMD in almost detective sites than healthy controls; the decline of lumbar spine BMD was earlier than HC. RA patients were more likely to comorbid with osteopenia and osteoporosis (p for trend <0.001) in the lumbar spine than HC. Higher serum 25-hydroxyvitamin D3 level and using tumor necrosis factor inhibitor in the last year, aging, lower body mass index, and increased serum uric acid were associated with bone loss.
Conclusions. RA patients were more prone and earlier to have bone loss than HC. More attention should be paid to measuring BMD in RA patients aging with lower BMI or hyperuricemia. Besides, serum vitamin D and all three detective sites are recommended to check routinely. TNFi usage in the last year might benefit bone mass.
Figure 1
Figure 2
No competing interests reported.
This is a list of supplementary files associated with this preprint. Click to download.
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