This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Therapeutic Effects and Molecular Network Mechanism of Chinese herbs for Coronavirus Disease-19
Yan Zha
Guizhou Provincial People's Hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The coronavirus disease-19 (COVID-19) outbreak on December 2019.The present study was aimed to explore the therapeutic effects and the network pharmacology mechanism of Chinese herbs in COVID-19 patients.
Methods: In this retrospective study, demographic, clinical signs, radiography, and laboratory of 78 patients were analysis from patients' medical records. Network pharmacology was applied to characterize the action mechanism of herbs decoction.
Results: Of all patients were imported cases with familial aggregation. Survival analysis showed that the proportion of cough (χ2 =3.864, P=0.049) and fever (χ2 =5.549, P=0.018) in TCM group declined faster than control group. There was a significant radiographic lesions remission difference between groups (χ2 =7.666, P=0.006). After adjusted by baseline data, the changes of Lymphocytes, ALT and LDH were greater in TCM group (P=0.023, 0.005, 0.015, respectively). A total of 1852 ingredients in 13 herbs were obtained, among which, the ingredients-target network included 168 compounds and 189 targets, 38 GO terms and 63 pathways were found in enrichment analysis.
Conclusion: The therapeutic effect of Chinese herbs was amelioration of cough and fever, facilitated the absorption of inflammatory infiltrates seen in the lungs, and increased the number of lymphocytes, protection of liver function via the mechanism of inhibition of coronavirus attack organs and immune cells directly. Molecular mechanisms need to be further validate in vitro and vivo.
Keywords
The coronavirus disease-19, integrated traditional Chinese and Western medicine, network pharmacology analysis, Quercetin, Prostaglandin G/H synthase 2
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 May, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Clinical Pharmacology
Learn more about our company.
This is a preprint. It has not completed peer review.
Research
Therapeutic Effects and Molecular Network Mechanism of Chinese herbs for Coronavirus Disease-19
Yan Zha
Guizhou Provincial People's Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 May, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Clinical Pharmacology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The coronavirus disease-19 (COVID-19) outbreak on December 2019.The present study was aimed to explore the therapeutic effects and the network pharmacology mechanism of Chinese herbs in COVID-19 patients.
Methods: In this retrospective study, demographic, clinical signs, radiography, and laboratory of 78 patients were analysis from patients' medical records. Network pharmacology was applied to characterize the action mechanism of herbs decoction.
Results: Of all patients were imported cases with familial aggregation. Survival analysis showed that the proportion of cough (χ2 =3.864, P=0.049) and fever (χ2 =5.549, P=0.018) in TCM group declined faster than control group. There was a significant radiographic lesions remission difference between groups (χ2 =7.666, P=0.006). After adjusted by baseline data, the changes of Lymphocytes, ALT and LDH were greater in TCM group (P=0.023, 0.005, 0.015, respectively). A total of 1852 ingredients in 13 herbs were obtained, among which, the ingredients-target network included 168 compounds and 189 targets, 38 GO terms and 63 pathways were found in enrichment analysis.
Conclusion: The therapeutic effect of Chinese herbs was amelioration of cough and fever, facilitated the absorption of inflammatory infiltrates seen in the lungs, and increased the number of lymphocytes, protection of liver function via the mechanism of inhibition of coronavirus attack organs and immune cells directly. Molecular mechanisms need to be further validate in vitro and vivo.
Figure 1
Figure 2
Figure 3