Abnormal higher order aberrations in anisometropic amblyopia
The study compared ocular higher-order aberrations (HOAs) between monocular anisometropic amblyopia children and similar anisometropia children with normal best-corrected visual acuity (BCVA). The amblyopia eyes could not reach the standard BCVA level of their age even after several months' regular treatment of amblyopia. We tried to find if these intractable amblyopia eyes have abnormal HOAs.
Fifty school-aged children (5–9 years) with hyperopic anisometropia were recruited at West China hospital clinic. Each subject shall be reexamined once every three months, four consecutive reexaminations for 12 months, of which only 25 subjects with normal BCVA after wearing glasses shall be included in the control group. The rest 25 subjects were treated by glasses and six months’ patching. Their interocular difference of visual acuity was still more than or equal to LogMAR 0.2, and the eyes with poor visual acuity did not reach the normal level in the twelfth month. These subjects were included in the amblyopia group. The BCVA, HOAs (5 mm pupil diameter), and axial length were recorded for all subjects.
There were significant differences of higher order aberrations in C (3, -3) between the amblyopia eyes and the other three groups of eyes with normal BCVA (all p < 0.05). There were significant differences of higher-order aberrations in third-order root-mean-square aberrations(RMS) between the amblyopia eyes and the low-diopter eyes from two subject groups(both p < 0.05). Compared to high-diopter eyes in the control group, there were a significantly higher C(3,-3) in all amblyopia eyes and a significantly higher third-order RMS (p = 0.040) in the moderate-to-severe amblyopia group. In the Pearson correlation test, the C(3,-3) and third order RMS demonstrated statistically significant correlations with BCVA ( (r=-0.19, p = 0.04; r = 0.37, p < 0.01).
The anisometropic amblyopia eyes had different HOAs from the eyes with normal visual acuity. The third-order aberrations were the primary abnormal higher-order aberration in amblyopia eyes.
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Posted 12 Jun, 2020
Abnormal higher order aberrations in anisometropic amblyopia
Posted 12 Jun, 2020
The study compared ocular higher-order aberrations (HOAs) between monocular anisometropic amblyopia children and similar anisometropia children with normal best-corrected visual acuity (BCVA). The amblyopia eyes could not reach the standard BCVA level of their age even after several months' regular treatment of amblyopia. We tried to find if these intractable amblyopia eyes have abnormal HOAs.
Fifty school-aged children (5–9 years) with hyperopic anisometropia were recruited at West China hospital clinic. Each subject shall be reexamined once every three months, four consecutive reexaminations for 12 months, of which only 25 subjects with normal BCVA after wearing glasses shall be included in the control group. The rest 25 subjects were treated by glasses and six months’ patching. Their interocular difference of visual acuity was still more than or equal to LogMAR 0.2, and the eyes with poor visual acuity did not reach the normal level in the twelfth month. These subjects were included in the amblyopia group. The BCVA, HOAs (5 mm pupil diameter), and axial length were recorded for all subjects.
There were significant differences of higher order aberrations in C (3, -3) between the amblyopia eyes and the other three groups of eyes with normal BCVA (all p < 0.05). There were significant differences of higher-order aberrations in third-order root-mean-square aberrations(RMS) between the amblyopia eyes and the low-diopter eyes from two subject groups(both p < 0.05). Compared to high-diopter eyes in the control group, there were a significantly higher C(3,-3) in all amblyopia eyes and a significantly higher third-order RMS (p = 0.040) in the moderate-to-severe amblyopia group. In the Pearson correlation test, the C(3,-3) and third order RMS demonstrated statistically significant correlations with BCVA ( (r=-0.19, p = 0.04; r = 0.37, p < 0.01).
The anisometropic amblyopia eyes had different HOAs from the eyes with normal visual acuity. The third-order aberrations were the primary abnormal higher-order aberration in amblyopia eyes.