Lee 2009
|
61/M
|
negative
|
History of renal cyst for 20 yrs
|
Necrotic, partially calcified, renal cyst 8.5 cm
|
Foci of large lymphoid cells within necrosis
|
CD22+, CD45+, CD79a+, MUM1+, PAX5+, CD3-, CD10-, CD20-, CD138-, BCL6-, ALK1-, HHV8-, k-, l-, EBER+. Ig clonality NP
|
Staging NA Surgery+ CHOP
|
NA
|
|
Dimitrova2010
|
51/M
|
negative
|
Acute obstructive left heart failure
|
Atrial myxoma
|
Foci of large lymphoid cells at myxoma surface
|
CD20+, CD10+. Ki67 high EBV: NV; Ig clonality: NP
|
Staging: neg Surgery+ CHOP
|
NA
|
|
|
Berrio 2010
|
60/M
|
negative
|
Acute left ventricular failure. History of aortic valve prosthesis for stenosis
|
Aortic valve prosthesis (covered by vegetations)
|
Foci of large lymphoid cells within valve vegetations
|
CD20+, CD43+, CD3-. Ki67:80-90% EBV: NV; Ig clonality: NP
|
Staging: neg Surgery only
|
Died for tricuspidal endocarditis, pneumonia 2yrs later No autopsy.
|
|
Loong 2010
|
29/M
|
negative
|
Abdominal pain
|
splenic false cyst 18 cm
|
Foci of large lymphoid cells (each max 1.5mm) within necrosis
|
CD20+, CD79a+, PAX5+, CD43+, MUM1+, CD10-, BCL6-CD138-, BCL2+, CD30-, HHV8-, CD3-. Ki67 90%. LMP1+, EBNA2+, EBER+. Ig clonality: +.
|
Staging: neg Surgery (splenectomy)+ R
|
NED at 6 mo
|
|
Loong 2010
|
88/M
|
negative
|
Fever, scrotal pain and swelling
|
Chronic hydrocele 10.5 cm (since 18 yrs)
|
Foci of large lymphoid cells within necrosis
|
CD20+, CD79a+, PAX5+, MUM1+, CD10-, BCL6-, CD138-, BCL2+, CD30-, HHV8-, CD3+, CD2-, CD5-, CD7-. Ki67 70% LMP1+, EBNA2+, EBER+. Ig clonality -.
|
Staging NA Surgery only (Orchidectomy)
|
NA
|
Loong 2010
|
70/F
|
negative
|
Ischemic stroke
|
Atrial myxoma
|
Foci of large lymphoid cells (each 1 mm max)
|
CD20+, CD79a+, PAX5+, CD43+, MUM1+, CD10-, BCL6+, BCL2+, CD30+, CD138-, HHV8-, CD3-. Ki67 100%. LMP1+, EBNA2+, EBER+. Ig clonality +.
|
Staging: neg Surgery + R-CEOP
|
Died for CT complications (neutropenia+ pneumonia) at 5 mo. No autopsy
|
Miller 2010
|
48/M
|
negative
|
Ischemic attack. Marfan sy. History of asc.a. aneurysm graft+ aortic valve prosthesis (24 yrs before)
|
Thrombus in the asc. a. graft
|
Foci of large lymphoid cells within fibrin
|
CD20+, MUM1+, CD10-, BCL6- BCL2+, CD3-, HHV8-. EBER+. Ig clonality+.
|
Staging: neg Surgery only
|
NED at 6 mo
|
Miller 2010
|
80/F
|
negative
|
Heart failure Aortic valve prosthesis for degenerative aortic stenosis (8 yrs before)
|
Thrombus of aortic valve prosthesis
|
Foci of large lymphoid cells within fibrin
|
CD20+, MUM1+, CD10-, BCL6-BCL2-, CD3-, HHV8-, EBER+. Ig clonality: +.
|
Staging: neg Surgery only
|
Died for breast carcinoma 18 mo after aortic valve surgery. No autopsy.
|
Miller 2010
|
79/F
|
negative
|
Short breath, thoracic pulsing sensation. Tube graft for asc.a. dissection (5 yrs before)
|
Pseudo-aneurysm at the end of tube graft
|
Foci of large lymphoid cells within fibrin
|
CD20+, MUM1+, CD10-, BCL6+, BCL2+, CD3-, HHV8-, EBER+. Ig clonality: +.
|
Staging: neg Surgery only
|
Died for surgical complications No autopsy
|
|
Valli 2011
|
46/M
|
negative
|
Left-sided flank pain
|
Renal pseudocyst 12 cm
|
Foci of large lymphoid cells within necrosis
|
CD20+, MUM1+, CD10-, BCL6-BCL2+, CD30-, HHV8-;Ki67:90%. EBER+. Ig clonality: NP
|
Staging: neg Surgery+ R-CHOP
|
NED at 1 mo
|
|
|
|
Gruver 2012
|
55/M
|
negative
|
Stroke symptoms. Aortic graft for aneurysm (4 yrs before)
|
Thrombus of aortic graft
|
Foci of large lymphoid cells within thrombus
|
CD20+, CD79a+, PAX5+, CD30+, CD43+, CD45+, BCL6+, MUM1+, BCL2-, CD10-, CD3-, CD5-, HHV8-, MYC-; KI67 100% LMP1+, EBNA2+.EBER+ Ig clonality: +.
|
Staging: neg Surgery + R-CEOP
|
NED at 16 mo
|
|
|
|
Gruver 2012
|
56/M
|
negative
|
short breath
|
Atrial thrombus
|
Foci of large lymphoid cells within fibrin thrombus
|
CD20+, CD79a+, PAX5+, CD30+, CD43-, CD45+, BCL6+, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC+30%; KI67 >90% LMP1+, EBNA2+.EBER+. Ig clonality: +.
|
Staging: neg Surgery+ R-CHOP
|
NED at 8 mo
|
|
|
|
Gruver 2012
|
75/M
|
negative
|
Dyspnea, aortic insufficiency, mitral valve regurgitation
|
Myxomatous mitral valve
|
Foci of large lymphoid cells within fibrin on mitral valve
|
CD20+, CD79a+, PAX5+, CD30-, CD43-, CD45+, BCL6-, MUM1+, BCL2+, CD10-, CD3-, CD5-, HHV8-, MYC -. KI67100%. LMP1-, EBNA2-. EBER-. Ig clonality: +.
|
Staging: neg Surgery+R-CVP (1 cy)+R-CHOP (6 cys)
|
NED at 39 mo
|
|
|
|
Svec 2012
|
60/F
|
negative
|
Embolic brain ischemia
|
Atrial myxoma
|
Foci of large lymphoid cells (2.2 mm)
|
CD20+, CD79a+, PAX5+, CD10-MUM1+, CD23+, BCL2+, BCL6-, CD5-, CD3-, cyclin D1-, CD138-, CD38-; Ki67: 100%. LMP1+, EBER+, EBNA2+. FISH MYC, BCL2, BCL6 -. Ig clonality NP
|
Staging: neg Surgery+ R-CHOP.
|
NED at 7 mo
|
|
|
Boroumand 2012
|
63/F
|
negative
|
Right abdominal pain
|
adrenal pseudocyst (26 cm)
|
Foci of large lymphoid cells within fibrin
|
CD20+, CD79a+, PAX5+, MUM1+, BCL2+, CD3-, CD10-, CD30- , BCL6-, HHV8-. Ki67 >90%. LMP1-; EBER+. Ig clonality NP
|
Staging: neg Surgery + R-CHOP+RT
|
NED at 40 mo
|
|
|
Boroumand 2012
|
27/M
|
negative
|
R. scrotal swelling. Herniorraphy followed by l. scrotal hematoma removed (3 yrs before)
|
Scrotal pseudocyst in the R. testis 9 cm
|
Foci of large lymphoid cells within fibrin
|
CD20+, CD79a+, CD30+, MUM1+, BCL2+, CD3-, CD10- BCL6-, HHV8-. Ki67>90%. LMP1+, EBER+. Ig clonality: NP
|
Staging: neg Surgery only
|
NED at 9 mo
|
|
|
Sugita 2012
|
77/M
|
negative
|
History of dementia due to head trauma (20 yrs before)
|
Chronic subdural hematoma
|
Foci of large lymphoid cells
|
CD20+, CD79a+, MUM1+, CD3-, BCL6-, CD10-. Ki67 high. EBNA2+, LMP1-, EBER+. Ig clonality - (rare neoplastic foci)
|
Staging: neg Surgery only
|
NA
|
|
|
Bartoloni 2013
|
55/F
|
negative
|
Fatigue, fever
|
Atrial myxoma
|
Foci of large lymphoid cells at myxoma surface
|
LCA+, CD20+, CD79a+, MUM1+, HHV8-, CD3-, CD5-. Ki67: 90%. LMP1+, EBNA2-, EBER+ Ig clonality: NP
|
Staging: neg Surgery only
|
NED at 72 mo
|
|
|
Valli 2014
|
56/F
|
negative
|
Abdominal pain+ swelling
|
Ovarian mature cystic teratoma
|
Foci of large lymphoid cells
|
CD20+, MUM1+, CD45+, PAX5+, CD30-, BCL6-, CD10-, CD3-, CD2-, HHV8-, CD138-. Ki67: 80%. EBER+ Ig clonality +
|
Staging: neg Surgery+ R-CHOP
|
NED at 8 mo
|
|
|
Hayes 2014
|
91/M
|
negative
|
Thigh hematoma. (6 yrs before leg amputation for popl. a. aneurysm rupture at site of prior artery bypass graft)
|
Popl. a. aneurysmal hematoma
|
Foci of large lymphoid cells
|
CD45+, CD20+, MUM1+, CD30+, CD43+, BCL2+/-, MYC+, p53+/-, HHV8-, CD3-, CD5-, CD10-, BCL1-, BCL6-. Ki67: 90%. LMP1-, EBER+. Ig clonality: NP
|
Staging: neg Surgery only.
|
NED at 18 mo
|
|
|
Aguilar 2015
|
52/M
|
negative
|
Dysarthria and hemiplegia
|
Atrial myxoma
|
Foci of large lymphoid cells
|
CD20+, CD79a+, PAX5+, CD30+, MUM1+, ALK1-, CD10-, CD43-, cyclinD1-, CD3-, LMP1+, EBNA2+, EBER+. Ig clonality +
|
Staging: neg Surgery only
|
NED at 42 mo
|
|
|
Tapan 2015
|
49/M
|
negative
|
palpitations
|
Atrial myxoma
|
Foci of large lymphoid cells
|
CD20+, CD79a+, CD30+, MUM1+, CD3-, CD5-, CD10-, CD138-, cyclin D1-, ALK1-, EMA-. Ki67 80%. EBNA2+, EBER+. Ig clonality: NP
|
Staging: neg Surgery +R-CHOP
|
NED at 12 mo
|
|
|
Kameda 2015
|
96/M
|
negative
|
Gait disturbs+ anorexia. History of trauma+ subdural hematoma (7 mo before).
|
Brain mass beneath subdural hematoma
|
Brain mass: DLBCL EBV+. Subdural hematoma: FA-DLBCL. No continuity among 2 lesions
|
CD20+, CD79a+, CD3-, CD4-, CD7-, CD8-, LMP1+, EBNA2+, EBER+. Ig clonality: NP
|
Staging: neg at presentation. Brain mass+ subdural hematoma resection. IT MTX + cytarabine+ glucocorticoids
|
Died after 3 mo for lymphoma dissemination. No autopsy
|
|
|
Kirshenbaum 2017
|
81/M
|
negative
|
Tremor, gait ataxia, memory disturbs
|
Arachnoid cyst
|
Foci of large lymphoid cells within fibrin
|
CD20+ CD30+, BCL2+, MUM1+, BCL6+/-, CD10-, TdT-, CD5-, cMYC+ (50%) Ki67: >80%. EBER+. FISH MYC: - Ig clonality +.
|
Staging: neg Surgery (cyst excision)+ R+ lenalidomide
|
NA
|
|
|
Boyer 2017
|
54/F
|
negative
|
syncope
|
Atrial myxoma
|
Foci of large lymphoid cells
|
CD20+, PAX5+, CD79a+, BCL6+, CD30+, CD10-, CD138- CD3-, HHV8-, Ki67 80%. EBER+. Ig clonality: NP
|
Staging: neg Surgery Other therapy: NA
|
NED at 130 mo
|
|
|
Boyer 2017
|
55/F
|
negative
|
Syncope, cough, dyspnea
|
Atrial myxoma
|
Foci of large lymphoid cells
|
CD20+, PAX5+, CD79a+, BCL6+, MUM1+, CD10-, CD45+, CD30+, HHV8-, CD138-, CD3-. Ki67: >95%. EBER+, LMP1+, EBNA2+. FISH for MYC-Ig clonality: NP
|
Staging: neg Surgery only
|
Died at 2 mo for cardiac cause. Autopsy: No lymphoma
|
|
|
Boyer 2017
|
54/M
|
negative
|
Dyspnea, respiratory failure
|
Atrial myxoma
|
Foci of large lymphoid cells
|
CD20+, PAX5+, BCL6+, MUM1+, CD10-, CD38+, CD45+, CD30+, CD3-. Ki67:90% EBER+, LMP1+, EBNA2+. FISH MYC, BCL6, BCL2: - Ig clonality: NP
|
Staging: neg Surgery only
|
Recurrent FA-DLBCL at mitral valve after 25 mo. Died at 26 mo (embolic stroke). No autopsy.
|
|
|
Boyer 2017
|
56/M
|
negative
|
IR aorta+ CIA aneurysms. TAA aneurysm graft plus thrombectomy (1 yr before). Asc a. dissection graft (9 yrs before).
|
Aneurysms of IR aorta and CIA with thrombus
|
Foci of large lymphoid cells within thrombus of IR aorta and CIA aneurysms. In retrospect foci within thrombus of TAA aneurysm
|
CD20+, PAX5+, BCL6-, MUM1+, CD10-, CD138-, HHV8-, CD30+, KI67: 95%. EBER+, LMP1+, EBNA2+. FISH for MYC -. Ig clonality +.
|
Staging: neg. Surgery+ R-CHOP+IT MTX
|
AWSD at 24 mo. Surgical revision of aortic graft: persistent foci of EBV+ large B cell.
|
|
|
Boyer 2017
|
68/M
|
negative
|
Lower limbs ischemia. AA aneurysm repair with IR graft (7 yrs before).
|
Thrombus from aorta next to graft, (extending into left CIA+ emboli in left femoral+ popliteal A).
|
Foci of large lymphoid cells within thrombus
|
CD20+, PAX5+, BCL6+, CD10-MUM1+, CD30+, HHV8-, KI67 90%, EBER+, LMP1+, EBNA2+. FISH for MYC -, Ig clonality NP
|
Staging neg. After 3 mo: PET/CT/biopsy: foci of EBV+ cells near adrenal gland. R-COEP (2 cys only for worsening conditions)
|
Died at 10 mo for embolic stroke. No progressive lymphoma. No autopsy
|
|
|
Boyer 2017
|
71/M
|
MG for THY treated with surgery+ steroids+AZA
|
AF graft (6 yrs before).
|
Hematoma associated with graft
|
Foci of large lymphoid cells within thrombus associated with graft
|
CD20+, CD79a+, PAX5+, CD10-BCL6+, MUM1+, CD30+, CD45+, CD138-, HHV8-, KI67>95%, EBER+, LMP1+. Ig clonality +.
|
Staging: neg Surgery only
|
NED at 10 mo
|
|
|
Boyer 2017
|
79/M
|
negative
|
Testicular trauma (5 yrs before)
|
Testicular hematoma (11.5 cm)
|
Foci of large lymphoid cells within hematoma
|
CD20+, PAX5+, CD79a+, CD10-CD138-, BCL6-, MUM1+, CD45+, CD30+, HHV8-, KI67 > 90%, EBER+, LMP1+, EBNA2+. Ig clonality +.
|
Staging: neg. Surgery only
|
NED. Died at 17 mo
|
|
|
Boyer 2017
|
25/M
|
negative
|
SD hematoma since child. Hydrocephalus+SD catheter. Steroid tp for pituitary overactivity
|
chronic SD hematoma requiring surgery for size increase
|
Foci of large lymphoid cells within hematoma
|
CD20+, PAX5+, MUM1+, CD10-BCL6-, CD30+, HHV8-, KI67>90%; EBER+, LMP1+. Ig clonality NP
|
Staging: neg. Surgery only
|
NED at 7 mo
|
|
|
Boyer 2017
|
37/F
|
negative
|
splenic cystic mass (9 cm) incidentally found
|
Splenic pseudocyst
|
Foci of large lymphoid cells within fibrin
|
CD20+, PAX5+, MUM1+, CD10-BCL6-, CD30-, CD45+, KI67>90% EBER+. Ig clonality NP
|
Staging: neg. Surgery +R-CHOP
|
NED at 32 mo
|
|
|
Boyer 2017
|
73/M
|
negative
|
Femoral a. aneurysm repair
|
Retro. pseudocyst (9cm)
|
Foci of large lymphoid cells within fibrin
|
CD20+, PAX5+, CD79a+, BCL6-, CD10-, MUM1+, CD30+, CD45+, HHV8-, KI67>95%, EBER+. Ig clonality NP
|
Staging: neg Surgery+ R-CHOP
|
NED at 43 mo
|
|
|
Boyer 2017
|
70/M
|
negative
|
Adrenal mass (7 cm) causing bladder obstruction
|
Adrenal pseudocyst
|
Foci of large lymphoid cells within fibrin
|
CD20-, PAX5+, CD79a+, BCL6-, CD10-, MUM1+, CD45+, CD30+, CD138-, HHV8-, KI67>90%, LMP1-, EBNA2+, EBER+. FISH for MYC -, Ig clonality NP
|
Staging: neg Surgery only
|
NED at 14 mo
|
|
|
Boyer 2017
|
44/M
|
negative
|
Right flank pain for 10 cm retro. cyst
|
Retro. pseudocyst
|
Foci of large lymphoid cells within fibrin
|
CD20+, PAX5+, CD10-, BCL6-, MUM1+, CD45+, CD30-, KI67 40%, LMP1+, EBNA2+, EBER+, FISH for MYC -, Ig clonality +.
|
Staging: neg CHOP
|
NED at 84 mo
|
|
|
Yan 2017
|
46/F
|
negative
|
Congestive heart failure
|
Atrial myxoma
|
Foci of large lymphoid cells within fibrin
|
CD20+, CD79α+, MUM1+, CD10-, BCL6-, CD30+. ALK-, BCL2-, CD3-, CD5-, Ki67 85% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP
|
Staging: neg Surgery only
|
NED at 120 mo
|
|
|
Yan 2017
|
61/F
|
negative
|
Congestive heart failure
|
Atrial myxoma
|
Foci of large lymphoid cells within fibrin
|
CD20+, CD79α+, MUM1+, CD10+, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 95% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP
|
Staging: neg Surgery only
|
NED at 84 mo
|
|
|
Yan 2017
|
54/M
|
negative
|
Congestive heart failure
|
Atrial myxoma
|
Foci of large lymphoid cells within fibrin
|
CD20+, CD79α+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP
|
Staging: neg. Surgery only
|
NED at 7 MO
|
|
|
Yan 2017
|
46/F
|
negative
|
Congestive heart failure
|
Atrial myxoma
|
Foci of large lymphoid cells within fibrin
|
CD20+, CD79α+, MUM1+, CD10-, BCL6+, CD30+. ALK-, BCL2+, CD3-, CD5-, Ki67 90% LMP1+, EBNA-2+, EBER+, FISH for MYC, Bcl6, BCL2-. Ig clonality NP
|
Staging: neg. Surgery only
|
NED at 3 mo
|
|
|
Zanelli 2019
|
71/F
|
negative
|
Lower limbs edema+ abdominal distension
|
Adrenal pseudocyst (34 cm)
|
Foci of large lymphoid cells within fibrin
|
CD20+, PAX5+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%. Ig clonality NP
|
Staging: neg Surgery only
|
NED at 6 mo
|
|
|
Present case
|
64/F
|
negative
|
Cerebral hemorrhage. Left middle cerebral artery aneurysm
|
Cerebral hemorrhage.
|
Foci of large lymphoid cells within fibrin
|
CD20+/-, PAX5+, CD79a+, CD30+, MUM1+, CD10-, BCL6-, EBER+, Ki67 90%. Ig clonality NP
|
Staging: neg Surgery only
|
NED at 5 mo
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|