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Research article
Dongsheng Huang
Beijing Tongren Hospital,Capital Medical University
Corresponding Author
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Background The study aimed to summarize the clinical data of hepatoblastoma (HB) in infants under 1 year of age, analyze their treatment effects and factors that affect the prognosis.
Methods Clinical data of 132 pathologically confirmed children under the age of 1 year old with hepatoblastoma who were admitted to the pediatric single center of Beijing Tongren Hospital,Capital Medical University from May 2005 to May 2019 were collected. The clinical efficacy and prognosis of combined treatment were summarized through retrospective analysis.
Results 1. Of the 132 children enrolled, 74 were male and 58 were female; median age was 8.40 months; the onset of disease was the most common (75.0%) of abdominal distension; infant HB had high AFP at the initial diagnosis, with an median level of 154725.0ng/ml; the platelet value was (405 ± 166) × 109/L; the pathological type was mainly epithelial (57.6%), and most of the epithelial types were fetal (67.1%); the PRETEXT stage was mainly stage III (54.5%), followed by stage II (34.1%); 45 cases had distant metastases, most of which were lung metastases (86.7%); 24 patients (18.2%) had portal vein or hepatic vein or vena cava invasion, 5 (3.8%) had tumor rupture, and 26 (19.7%) had multiple intrahepatic lesions. 2. The patients were followed up to May 2020, with a median follow-up time of 58 months. Among them, 84 cases had complete remission and 18 cases had partial remission. According to Kaplan-Meier survival analysis, the 5-year overall survival rates (OS) were 80.1%; the event-free survival rates (EFS) were 77.5%. Log-rank test showed that patients with AFP> 100ng/ml at first diagnosis had a good prognosis; the EFS of the patients at PRETEXT IV stage was only 28.6%; children with distant metastasis and multiple primary tumor lesions had 63.5% and 31.5% EFS at 5 years, both of which had poor prognosis and were risk factors affecting the prognosis of infants with HB (P < 0.05); the 5-year EFS for the patients with primary tumor complete resection is 74.2%.
Conclusions Infant HB has its own characteristics. Through comprehensive treatment, the prognosis is relatively good, but it is still susceptible to multiple factors such as AFP level, PRETEXT stage, the presence of distant metastasis and multiple intrahepatic lesions.
Keywords
hepatoblastoma, infant, AFP, chemotherapy, prognosis
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This is a preprint. It has not completed peer review.
Research article
Dongsheng Huang
Beijing Tongren Hospital,Capital Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 2
Posted 02 Sep, 2020
No community comments so far
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pediatrics
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background The study aimed to summarize the clinical data of hepatoblastoma (HB) in infants under 1 year of age, analyze their treatment effects and factors that affect the prognosis.
Methods Clinical data of 132 pathologically confirmed children under the age of 1 year old with hepatoblastoma who were admitted to the pediatric single center of Beijing Tongren Hospital,Capital Medical University from May 2005 to May 2019 were collected. The clinical efficacy and prognosis of combined treatment were summarized through retrospective analysis.
Results 1. Of the 132 children enrolled, 74 were male and 58 were female; median age was 8.40 months; the onset of disease was the most common (75.0%) of abdominal distension; infant HB had high AFP at the initial diagnosis, with an median level of 154725.0ng/ml; the platelet value was (405 ± 166) × 109/L; the pathological type was mainly epithelial (57.6%), and most of the epithelial types were fetal (67.1%); the PRETEXT stage was mainly stage III (54.5%), followed by stage II (34.1%); 45 cases had distant metastases, most of which were lung metastases (86.7%); 24 patients (18.2%) had portal vein or hepatic vein or vena cava invasion, 5 (3.8%) had tumor rupture, and 26 (19.7%) had multiple intrahepatic lesions. 2. The patients were followed up to May 2020, with a median follow-up time of 58 months. Among them, 84 cases had complete remission and 18 cases had partial remission. According to Kaplan-Meier survival analysis, the 5-year overall survival rates (OS) were 80.1%; the event-free survival rates (EFS) were 77.5%. Log-rank test showed that patients with AFP> 100ng/ml at first diagnosis had a good prognosis; the EFS of the patients at PRETEXT IV stage was only 28.6%; children with distant metastasis and multiple primary tumor lesions had 63.5% and 31.5% EFS at 5 years, both of which had poor prognosis and were risk factors affecting the prognosis of infants with HB (P < 0.05); the 5-year EFS for the patients with primary tumor complete resection is 74.2%.
Conclusions Infant HB has its own characteristics. Through comprehensive treatment, the prognosis is relatively good, but it is still susceptible to multiple factors such as AFP level, PRETEXT stage, the presence of distant metastasis and multiple intrahepatic lesions.
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