This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Zhu Yuxi
Chongqing Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7563-505X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
The protein encoded by collagen type I alpha 1 chain(COL1A1)is a component of the extracellular matrix, and critical for tumor microenvironments. However, it remains unclear that the expression level, prognostic prediction, and immunological value of COL1A1 in multiple cancers.
Methods
4 profiles and 6 hub genes were found by bioinformatics analysis. We further analyzed one of the hub genes, the COL1A1. And, we comprehensively analyzed gene expression and genetic alteration patterns among 33 types of malignancies from The Cancer Genome Atlas(TCGA). Besides, we explored the correlation of COL1A1 with cancer prognosis, immune infiltrates, tumor mutational burden (TMB)/ microsatellite instability status (MSI), pathway and drug sensitivity analysis of co-expressed genes.
Results
COL1A1 was highly expressed and associated with poor prognosis in the majority of cancer. On the other hand, COL1A1 expression was closely related to high TMB in THYM, LAML, ACC, KICH, PRAD, and LGG. High MSI was observed in TGCT, MESO, PRAD, COAD, SARC, and CESC. In addition, COL1A1 was positively correlated with the abundance of CAFs, macrophages, and tumor-infiltrating lymphocytes. However, it was negatively correlated with CD8 + T cells mainly in CESC, HNSC-HPV+, and SKCM.
Conclusion
COL1A1 can serve as a prognostic and immunological biomarker in multiple cancers.
Keywords
COL1A1, pan-cancer, prognosis, tumor immune microenvironment, gastrointestinal cancer
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Zhu Yuxi
Chongqing Medical University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7563-505X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 17 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective
The protein encoded by collagen type I alpha 1 chain(COL1A1)is a component of the extracellular matrix, and critical for tumor microenvironments. However, it remains unclear that the expression level, prognostic prediction, and immunological value of COL1A1 in multiple cancers.
Methods
4 profiles and 6 hub genes were found by bioinformatics analysis. We further analyzed one of the hub genes, the COL1A1. And, we comprehensively analyzed gene expression and genetic alteration patterns among 33 types of malignancies from The Cancer Genome Atlas(TCGA). Besides, we explored the correlation of COL1A1 with cancer prognosis, immune infiltrates, tumor mutational burden (TMB)/ microsatellite instability status (MSI), pathway and drug sensitivity analysis of co-expressed genes.
Results
COL1A1 was highly expressed and associated with poor prognosis in the majority of cancer. On the other hand, COL1A1 expression was closely related to high TMB in THYM, LAML, ACC, KICH, PRAD, and LGG. High MSI was observed in TGCT, MESO, PRAD, COAD, SARC, and CESC. In addition, COL1A1 was positively correlated with the abundance of CAFs, macrophages, and tumor-infiltrating lymphocytes. However, it was negatively correlated with CD8 + T cells mainly in CESC, HNSC-HPV+, and SKCM.
Conclusion
COL1A1 can serve as a prognostic and immunological biomarker in multiple cancers.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
This is a list of supplementary files associated with this preprint. Click to download.
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