This preprint is under consideration at Systematic Reviews. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Protocol
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
Particulate matter (PM) is an important environmental risk factor in the initiation and exacerbation of respiratory disease. Various herbal medicines have exhibited a reduction in symptoms of respiratory diseases induced by PM in animal models; however, their efficacy, mechanism, and safety have not been reviewed. This review will evaluate the efficacy, safety, and mechanism of action of herbal medicines in respiratory diseases caused by PM.
Methods:
We will follow the scoping review framework developed by Arksey and O’Malley. MEDLINE (via PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials will be searched for relevant English-language publications, and only peer-reviewed, controlled comparative in-vivo/in-vitro studies examining the effects of herbs in animal models of respiratory disease induced by PM will be included. The basic characteristics, research method, possible mechanism, and results will be extracted. The primary outcome will be pulmonary function; secondary outcomes will be inflammatory markers, reactive oxygen species, histology and mechanisms, and adverse events. Two researchers will independently perform the study selection, data extraction, and quality assessment. RevMan software (version 5.3) will be used for the quantitative data synthesis. When appropriate, data will be pooled for meta-analysis using fixed or random effects models; otherwise, evidence will be summarized qualitatively.
Ethics and Dissemination:
Ethical approval is not required because individual patient data will not be included. The findings will be disseminated through peer-reviewed publications or conference presentations.
Registration number:
This review protocol has been registered with the Open Science Framework on February 12, 2021 (https://osf.io/s7uvk/)
Keywords
Particulate Matter, herbal medicine, Medicine, traditional, respiratory tract disease, in-vitro, in-vivo, scoping review
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementalDigitalContent1Appendix1.docx
Appendix 1_Search Strategy
- SupplementalDigitalContent2Appendix2.docx
Appendix 2_PRISMA-Scr Checklist
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Reviews received
Received 15 Oct, 2021
Reviewers invited
Invitations sent on 15 Oct, 2021
Editor assigned
On 29 Sep, 2021
Editor invited
On 29 Sep, 2021
Submission checks complete
On 08 Mar, 2021
First submitted
On 02 Mar, 2021
Metrics
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PDF Downloads: ...
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Subject Areas
Internal Medicine
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This preprint is under consideration at Systematic Reviews. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Protocol
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Reviews received
Received 15 Oct, 2021
Reviewers invited
Invitations sent on 15 Oct, 2021
Editor assigned
On 29 Sep, 2021
Editor invited
On 29 Sep, 2021
Submission checks complete
On 08 Mar, 2021
First submitted
On 02 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
Particulate matter (PM) is an important environmental risk factor in the initiation and exacerbation of respiratory disease. Various herbal medicines have exhibited a reduction in symptoms of respiratory diseases induced by PM in animal models; however, their efficacy, mechanism, and safety have not been reviewed. This review will evaluate the efficacy, safety, and mechanism of action of herbal medicines in respiratory diseases caused by PM.
Methods:
We will follow the scoping review framework developed by Arksey and O’Malley. MEDLINE (via PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials will be searched for relevant English-language publications, and only peer-reviewed, controlled comparative in-vivo/in-vitro studies examining the effects of herbs in animal models of respiratory disease induced by PM will be included. The basic characteristics, research method, possible mechanism, and results will be extracted. The primary outcome will be pulmonary function; secondary outcomes will be inflammatory markers, reactive oxygen species, histology and mechanisms, and adverse events. Two researchers will independently perform the study selection, data extraction, and quality assessment. RevMan software (version 5.3) will be used for the quantitative data synthesis. When appropriate, data will be pooled for meta-analysis using fixed or random effects models; otherwise, evidence will be summarized qualitatively.
Ethics and Dissemination:
Ethical approval is not required because individual patient data will not be included. The findings will be disseminated through peer-reviewed publications or conference presentations.
Registration number:
This review protocol has been registered with the Open Science Framework on February 12, 2021 (https://osf.io/s7uvk/)
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
- SupplementalDigitalContent1Appendix1.docx
Appendix 1_Search Strategy
- SupplementalDigitalContent2Appendix2.docx
Appendix 2_PRISMA-Scr Checklist
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