Community-based directly observed therapy is effective and results in better treatment outcomes for patients with multi-drug resistant tuberculosis in Uganda

doi:10.21203/rs.3.rs-2952595/v1

Background:

Health facility-based directly observed therapy (HF DOT) is the main strategy for the management of patients with drug-resistant tuberculosis (DR TB) in Uganda, however, this still yields sub-optimal treatment outcomes. We set out to assess the effectiveness of community-based directly observed therapy (CB DOT) for the treatment of DR TB in Uganda.

Methods:

Using a previously developed patient-centered model for CB DOT, we assigned community health workers (CHWs) as primary caregivers to patients diagnosed with DR TB. CHWs administered daily DOT to patients in their homes. Once a month, patients received travel vouchers to attend clinic visits for treatment monitoring. We assessed the effectiveness of this model using a quasi-experimental pre and post-study. From December 2020 to March 2022, we enrolled adult DR-TB patients on the CB DOT model. We collected retrospective data from patients who had received care using the HF DOT model during the year before the study started. The adjusted effect of CB DOT versus HF DOT on DR TB treatment success was estimated using modified Poisson regression model with robust cluster variance estimator.

Results:

We analyzed data from 264 DR TB patients (152 HF DOT, 112 CB DOT). The majority were males (67.8%) with a median age of 36 years (IQR 29 to 44 years). Baseline characteristics were similar across the comparison groups, except for educational level. The treatment success rate in the CB DOT group was 12% higher than that in the HF DOT (adjusted prevalence ratio (aPR)= 1.12 [95%CI 1.01, 1.24],

P-value=0.03). Males were less likely to achieve treatment success compared to their female counterparts (aPR=0.87 [95% CI 0.78, 0.98], P-value=0.02). A total of 126 (47.7%) of 264 patients reported at least one adverse event. The HF DOT group had a higher proportion of patients with at least one adverse event compared to the CB DOT group (90/152 [59.2%] versus 36/112 [32.1], P-value<0.01). The model was acceptable among patients (93.6%) and health workers (94.1%).

Conclusions:

CB DOT for DR-TB care is effective and results in better treatment outcomes than HF DOT. The cost-effectiveness of this model of care should be further evaluated.

Community-based care

Health Facility-based care

Directly Observed Therapy

Treatment Outcomes

Drug-resistant TB

Uganda

Drug-resistant tuberculosis (DR TB) continues to be a disease of public health interest globally. In 2018, there were approximately half a million new cases of DR TB reported, 78% of which were resistant to two major first-line anti-TB medicines, isoniazid and rifampicin(1). Of these, an estimated 3.4% were new cases of TB, while 18% were previously treated TB cases. In the same year, there were about 200,000 deaths from DR TB(1). Before the COVID-19 pandemic disrupted TB case detection and notification efforts, there was a slight increase in cases of DR TB as a proportion of all notified TB cases(1, 2).

Results from a national DR TB survey conducted in Uganda in 2010, showed an MDR TB prevalence of 1.4% and 12.1% among new and retreatment cases respectively(3). In 2018, the World Health Organization (WHO) estimated 1,100 DR TB cases among notified pulmonary TB cases in Uganda(1). In the same year, about 500 DR TB cases were started on treatment resulting in a 70% treatment success rate, a 15% mortality rate, and a 14% loss to follow-up rate for the 2016 treatment cohort(4), far below the national TB strategic plan (NSP) targets of 85% for treatment success and < 5% for all unfavorable outcomes(5).

Uganda implements a mixed model of care for persons diagnosed with DR-TB. Unless there is an indication for hospitalization e.g. critical illness, serious adverse events, respiratory insufficiency, or need for intensified adherence support, care is ambulatory (6). Treatment is initiated at tertiary referral hospitals, followed by daily directly observed therapy (DOT) at health facilities closest to the patient's home. Patients then return to the tertiary hospitals once every month for treatment monitoring and/or adverse event management. Patients who receive care through HF DOT experience various inconveniences (e.g. travel and waiting times) and incur significant direct (e.g. transport costs) and indirect costs (e.g. time lost from work) that contribute to the high rates of suboptimal treatment outcomes associated with HF DOT(7, 8). These suboptimal outcomes are a potential risk for the development and spread of further resistance to TB treatment.

In 2019, the WHO released updated guidelines for the management of DR TB that recommended the use of shorter all-oral regimens constructed using novel and repurposed drugs e.g. Bedaquiline (BDQ) and Linezolid (Lzd) respectively for all eligible patients, making community-based DOT (CB DOT) and the use of lay providers possible. (9). In response to the new recommendations from the WHO, Uganda introduced new injection-free, DR-TB treatment regimens in October 2020. These regimens included; 1) a bedaquiline-based injection-free shorter treatment regimen (the modified shorter treatment regimen) 2) individualized longer treatment regimens based on age, fluoroquinolone resistance, and site of the disease and 3) salvage regimens for patients with extensive resistance patterns(9). The introduction of these new regimens made CB DOT, which has been documented to result in better treatment outcomes in many settings(10–13) a possibility for Uganda. We set out to assess the effectiveness of CB DOT compared to HF DOT for the management of DR-TB in Uganda.

Study design

In 2019, we developed a CB DOT model for DR TB based on patient preferences elicited during a previous study. In the CB DOT model, community health workers were assigned as primary caregivers and received travel vouchers to administer DOTs in patients' homes (14). To assess the effectiveness of this model, we designed a quasi-experimental pre and post-study. It comprised of the observational prospective component (P-arm) which was the intervention group, to which MDR TB patients were enrolled onto CB DOT, and the retrospective component (R-arm) as the comparison group consisting of DR TB patients who received HF DOT.

Prospective arm

A CB DOT intervention developed in an earlier study was assigned to eligible MDR-TB patients consecutively (14). Patients were followed up prospectively until, treatment was completed, outcomes were assigned, or patients were administratively censored.

Retrospective arm

The comparison group was comprised of MDR-TB patients who were on HF DOT, initiated treatment in the previous year, and completed their treatment three months before the commencement of the study. Data for this group was collected retrospectively from the five DR TB treatment health facilities, including patients’ characteristics at MDR-TB treatment initiation and treatment outcomes. The same data collection tool was used for data collection for both the intervention and comparison groups.

Study setting

A multi-site study at five tertiary referral hospitals purposively selected which accounted for at least 80% of MDR cases enrolled in care in the country and were representative of the major regions of Uganda. Arua regional referral hospital (RRH), participated in the initial model development(14) but was not included in the evaluation of the model due to administrative challenges.

Selection of community health workers to support community-based DOT

The use of trained lay providers in the provision of DOT for DR TB patients is recommended by the programmatic management of drug-resistant tuberculosis (PMDT) guidelines in Uganda(9, 15). Previously, with regimens that included injectables, DOT was only recommended for provision by lay providers after the completion of the intensive phase that was characterized by injectables (Kanamycin, Amikacin, or Capreomycin)(15). However, the dawn of all oral medications makes the provision of CB DOT throughout the treatment cycle for MDR TB patients possible(9, 16, 17). We selected lay providers who were; 1) chosen by or acceptable to the patient 2) committed to supporting the patient throughout their treatment 3) able to read and write 4) not an immediate family member(14, 15) 5) able to accompany the patient to the clinic for monthly appointments 6) had previously supported health initiatives at the community level including TB and MDR TB 7) of good standing in the community and 8) living close to the patient and not take him or her more than an hour to reach the patient’s home. We planned that each community health worker (CHW) was to support daily DOT up to a maximum of three DR TB patients if within the same locality for efficiency and ease of administration. CHWs were trained on CB DOT model implementation, their role in supporting the DR TB patient, and DR TB specific training that focused on basic TB, TB classifications, the definition of DR TB, causes of DR TB, clinical presentation, medicines used, associated side effects, and drug storage. Ongoing support was availed to CHWs during monthly routine visits to the tertiary referral hospital.

Roles of CHWs

The roles of the CHWs included; 1) Conduct daily visits to the patient’s home to observe him/her swallowing the drug, 2) Record daily community DOT in the patient follow-up log that was presented at the DR TB treatment initiation facility every month 3) Observe during daily interaction with the patient and record any adverse events reported by the patient, any concerns or actions taken 4) Consult virtually with the site study focal person/ clinician on an ongoing basis on all aspects of care, including liaising with initiating facilities on the management of adverse events, including referrals 5) Remind patients of monthly health facility visits 6) Pick up drugs for MDR-TB patients monthly 7) Ensure safe custody/keeping of drugs in a drug box away from dust at room temprature 8) Provide patient health education and infection prevention and control messages to patients and members of the family about MDR- TB, and 9) Provide adherence counseling.

Selection of study participants

Sample size determination

The total number of DR-TB patients in care in the five health facilities by 2019 was 302 patients. Based on the 2018 /19 Uganda National Tuberculosis and Leprosy Program (NTLP) report, the approximate treatment success rate among MDR-TB patients in Uganda was 75%. Assuming a statistical power of 80%, a two-sided hypothesis test with a 5% significance level (standard normal deviate at 95% confidence, Z = 1.96). The desired sample size to detect a 10% increase in treatment success due to CB DOT to achieve the national target of treatment success of 85% was 185 patients in each arm. The estimatedsample size adjusted using finite population correction because of the limited available numbers of DR patients (18). Sampling proportionate to size was used to determine the number of study participants selected from each of the participating hospitals.

Study inclusion criteria

DR TB patients above 18 years of age on a standard short treatment regimen (sSTR)(15) who had completed the injectable phase of DR TB treatment, or those on an all oral modified STR (mSTR)(6) or, on long all oral regimens(6) at the point of enrolment onto the study, after providing signed informed consent, were willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other procedures relevant to assigning treatment outcomes.

Study exclusion criteria

DR TB patients who are on other individualized regimens that included injectables

Data collection

For the R-arm, retrospective data were extracted from DR-TB registers at the study hospitals using pre-designed data collection tools. For the P-arm, prospective data were collected by research assistants (RAs) using the same tool. Patients received daily visits by the CHWs, who observed medicine ingestion, noted any patient concerns and adverse events, and documented data in a patient log.

Study Variables

The main study outcome was the proportion of patients who registered treatment success (those who were cured or those who completed treatment) among those intiated DR TB treatment. The main comparison groups were DOT models of care, i.e. health facility based DOT (HF DOT) versus community-based DOT (CB DOT).

Other participants’ information collected include; Patient demographics (e.g. age, gender), occupation, high-risk populations, duration of MDR TB treatment and presence of co-infections (e.g. HIV).

Statistical Analysis

Quantitative analyses were conducted using STATA software version 16.1 (StataCorp, College Station, Texas, USA). We described participants’ socio-demographic characteristics for both HF DOT and CB DOT groups using descriptive summaries; frequency and percentages for categorical variables, median and inter-quartile range for count data, i.e. age and duration of MDR-TB treatment.

We use Pearson Chi-square test for categorical variables and Wilcoxon rank-sum test for continuous non-normal variables comparing HF DOT versus CB DOT groups. We used prevalence ratios and 95% confidence intervals to compare treatment success across HF DOT versus CB DOT groups using Poisson regression models with cluster-robust standard errors to account for intra-cluster correlation of participants within a hospital. The analysis was adjusted for participants’ characteristics. Modified Poisson regression was used because it estimates adjusted relative risk or prevalence ratios appropriately when the outcome is common (i.e. prevalence > 10%) compared to logistic regression, and it does not have model convergence challenges unlike log-binomial models(19). Only factors with P < 0.3 at unadjusted models were included in the multivarible model, except CB DOT type, the main comparison variable. Joint P-values using Wald test at unadjusted were used in the selection of variables with more than two categories in the adjusted model. We checked whether the effect of DOT type was modified by other participants’ characteristics, by fitting interactions between DOT type and MDR-TB treatment type, sex, and age groups was carried out.

From December 2020 to March 2022, a total of 286 MDR-TB patients were enrolled in the study, 22 were excluded because they were still on active treatment at time of follow-up closure (Table S1). Of the 264 patients that remained, 152 patients were in the HF DOT group (R) and 112 patients in the CB DOT group (P) (Fig. 1). Majority were males 67.8% with a median age of 36 years (inter-quartile range 29 to 44 years). The distribution of age, sex, marital status and income were similar across the comparison groups, except for educational level. The CB DOT group had a larger proportion of patients who had attained at least primary education (95% vs 91%). Daily income data was unavailable in the retrospective group (i.e. HF DOT group). (Table 1)

Treatment success was significantly higher in the CB DOT group compared to the HF DOT group (88% vs 13%, Chi-square test P value = 0.01) (Table 2).

Treatment success in the CB DOT group was 12%-points higher compared to that in the HF DOT group, after adjusting for the patient’s sex, age group, marital status, employment status, DR TB regimen duration type, and whether a patient had one or more comorbidities (adjusted prevalence ratio 1.12, 95%CI 1.01, 1.24, P value = 0.03). Males were less likely to achieve treatment success compared to their female counterparts (aPR = 0.87, 95%CI 0.78, 0.98, P value = 0.02). Whereas age groups, marital status, employment status, DR-TB regimen duration type, and having a comorbidity were not significantly associated with DR-TB treatment success. There was no significant effect modification of the effect of DR-TB DOT type due to other participants’ characterisitics (Table 3).

A total of 126 (47.7%) out of 264 patients reported at least one adverse event. The HF DOT group had a higher proportion of patients with at least one adverse event compared to the CB DOT group (90/152 [59.2%] versus 36/112 [32.1], P-value < 0.01) (Table 4).

The most common adverse events were gastrointestinal disorders (18.9%), flu-like symptoms (14.6%), musculoskeletal and connective tissue disorders (13.0%), general disorders and administration site conditions (12.8%), and nervous system disorders (12.8%) (Table S2).

We carried out a quasi-experimental pre and post-study to assess the effectiveness of a community-based model for the management of MDR-TB. Retrospective data were collected for patients who had received care under the HF DOT model a year before the study commenced. We found that CB DOT increased treatment success by 12-percentage points compared to the HF DOT group. Males were less likely to complete treatment compared to their female counterparts while other factors like age, marital status, employment status, and having any comorbidity were not significantly associated with DR TB treatment success. However, higher proportions of at least one adverse event was reported in HF DOT groupf compared to the CB DOT group. The model was found to be highly acceptable among DR-TB patients and health workers.

There is evidence from earlier studies for better treatment outcomes for MDR-TB patients managed using community-based models in Sub-Saharan Africa and Asia (12, 17, 20, 21). The increase in treatment success found in our study (12%) was comparable to that from a cohort study that engaged CHWs to provide home-based care for DR-TB patients in rural Eswatini (11%) (22). Improvements in treatment success documented by community-based models are probably due to the convenience and decrease in care costs associated with home-based care (23).

Globally, the male gender is disproportionately affected by TB (24–26). Men are also more likely to have suboptimal treatment outcomes (12, 26–29). Further, similar results were found among men in a community-based DOT model for the management of MDR-TB carried out in South Africa(30). Men are more likely to suffer from TB than women due to behavioral factors like smoking(31), drinking alcohol and drug abuse as well as occupational harzards (mining, construction and transportation)

In our study, age was not significantly associated with treatment outcomes. This is similar to findings from a systematic review and meta- analysis on treatment outcomes for DR-TB patients on a community-based model of careof studies on found that age was not a significant contributor to treatment outcomes irrespective of the model of care (20). However, in some instances, advanced age has been found to be significantly associated with unfavorable outcomes among MDR-TB(32–34). The findings in our study could be explained by the fact that the majority (78.9%) of the study participants were less than 45 years of age.

Social factors such as being married, being employed, and having social support have been documented to positively affect treatment outcomes among MDR-TB patients (35). These social factors were not significantly associated with successful treatment in this study and could be explained by the fact that Uganda NTLP implements an enabler program that provides all DR TB patients with dry rations and transport vouchers to facilitate monthly visits to tertiary hospitals for treatment monitoring, preventing their households from experiencing catastrophic costs(36). Comorbidities, including HIV, diabetes, and hypertension have been documented to contribute to poor treatment outcomes among DR-TB patients(37–39). Despite the fact that those infected with HIV showed a tendency towards poorer outcomes, our study did not find underlying comorbidities to be statistically significantly associated with treatment success. This could be have been due to small numbers in this category.

Similar to our study, lower rates of adverse events have been reported in other studies using community-based models of care for DR TB, it is possible that adverse events could have been underreported by CHWs. A systematic review carried out in 2016 showed that the most common adverse events were GIT(40), similar to our study. Suspected agents that cause GIT adverse reactions are majorly caused by ethionamide (Eto), bedaquiline (BDQ), and clofazimine (Cfz) (11) which are part of the available DR TB treatment regimens. Our study reported lower rates of ototoxicity due to a 2019 policy change in Uganda that called for a shift to all oral regimens with avoidance of injectables such as kanamycin likely to cause ototoxicity (6). Majority of patients on the R-arm were on injectable based regimens that were associated with more side effects compared to all oral regimens. It is possible that the lower rates of side effects in the P-arm compared to the R-arm was due to predominant regimen type other than the mode of delivery.

Further, community-based models for the management of MDR-TB have been documented to be acceptable among patients, lay providers, and healthcare workers elsewhere including in Uganda(14).

This study had many strengths. We included regional representation and hence findings can be generalized to all MDR-TB patients across the country. The prospective arm of the study provided better quality preliminary data on the primary exposure and was low on confounding since data about all known confounders was collected and controlled for during the analysis. Further studies using rigorous study designs like randomized controlled trials are recommended. Study limitations included travel restrictions during the COVID-19 pandemic that affected travel and hence ability to return to the clinic for scheduled appointments for refills. This has the potential to introduce bias due to preferrantial losses to foll-w up. The pre-post-study design has some limitations associated with temporal changes.

The R arm had some missing variables, for example income, making comparisons between the two groups difficult. Lastly, the data collection tool was designed to capture whether a patient was on sSTR or mSTR or other individualized regimens and not the individual DR-TB drug molecules, making it difficult to assess whether any differences in specific drugs used among the two groups could affect the outcome.

CB DOT for MDR-TB care is effective and results in better treatment outcomes than HF DOT. Community-based services for MDR-TB care should be adopted by the NTLP on a wider scale as it brings the services of care closer to the people. The use of lay workers to complement service delivery for MDR-TB is possible and can lead to improved patient outcomes. However, there is a need for more research to better understand the role of lay workers in the care of patients with MDR-TB and to develop effective models for their integration into the healthcare system. Further, the cost-effectiveness of this model of care should be further evaluated.

Recommendations for practice and policy

Develop national guidelines for the recruitment, training, and deployment of lay workers in the management of MDR-TB. It is critical to ensure that lay workers receive adequate training and supervision to provide effective and safe care to DR TB patients.
Integrate lay workers into the existing healthcare system and ensure that they work in collaboration with healthcare providers. This can help to improve communication and coordination of care, which is essential for successful treatment outcomes.
Monitor and evaluate the effectiveness of lay worker programs and foster partnerships between government, implementing partners and other stakeholders to support the implementation of lay worker programs for sustainability.

AE	Adverse event
BDQ	Bedaquiline
CB-DOT	Community-Based Directly Observed Therapy
CEA	Cost Effectiveness Analysis
CHW	Community health worker
Cfz	Clofazimine
Cs	Cycloserine
DLM	Delaminid
DOTS	Directly Observed Therapy Short Course
DOT	Directly Observed Therapy
DST	Drug Susceptibility Testing
GCP	Good Clinical Practice
FPC	Finite Population Correction
HCW	Healthcare Worker
HF-DOT	Health Facility Directly Observed Therapy
HIV	Human Immunodeficiency Virus
IDI	Infectious Diseases Institute
INH	Isoniazid
IRB	Institutional Review Board
Lfx	Levofloxacin
LZD	Linezolid
MDR-TB	Multidrug Resistant TB
mSTR	Modified short treatment regimen
MoH	Ministry of Health
MTB	Mycobacterium Tuberculosis
NRH	National Referral Hospital
NTLP	National TB and Leprosy Program
P-arm	Prospective arm
R-arm	Retrospective arm
RRH	Regional Referral Hospital
SAE	Serious Adverse Event
SMS	Short Message Service
sSTR	Standard Short Term Regimen
SRC	Scientific Review Committee
TB	Tuberculosis
URC	University Research Co., LLC
USAID	United States Agency for International Development
WHO	World Health Organization

Ethics approval and consent to participate

This research was performed in accordance with the Declaration of Helsinki guidelines. It was approved by the Joint Clinical Research Centre (JC1519) Institutional Review Board (IRB), and by the Uganda National Council of Science and Technology (HS2684) prior to study conduct. Administrative permission to collect this data were provided by the National TB and Leprosy Program and by respective study sites. Prior to interview commencement, written informed consent was voluntarily obtained from all participants. Confidentiality of patients was ensured by using study identification numbers and data storage protection procedures

Consent for publication

Not applicable.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on request.

Competing interests

The authors declare that they have no competing interests.

Funding

Support for the conduct of this study was provided by USAID through the Defeat TB Project. USAID Cooperative Agreement Number AID-617-A-17-00003.

Authors' contributions

RMM- Conceptualization, development of study protocol, supervision of study implementation and initial manuscript draft; JM- Conceptualization and Data analysis; SZM- Conceptualization, protocol review, and supervision of RMM; EK- Conceptualization and Technical MDR TB input; HN- Data curation; ST- Study conceptualization, enabled administrative processes; AN- Conceptualization, overall supervision, and final approval of the manuscript. All authors contributed to the critical review of the manuscript.

Acknowledgments

The authors are indebted to DR-TB patients in Uganda who participated in the study. We thank the administration, health workers of the various hospitals where this study was carried out for their invaluable support during the data collection processes. We thank the CHWs for the role they played in supporting DR TB patients during the study. We appreciate the effort of study nurses and clinicians especially Ms. Lilian Mujunju for her commitment, labor, and contribution towards the successful implementation of this study.

(WHO) WHO. Global Tuberculosis Report 2019 [Available from: https://www.who.int/publications/i/item/9789241565714.
(WHO). WHO. Global Tuberculosis Report 2021 [Available from: https://www.who.int/publications/i/item/9789240037021.
Lukoye D, Cobelens FG, Ezati N, Kirimunda S, Adatu FE, Lule JK, et al. Rates of anti-tuberculosis drug resistance in Kampala-Uganda are low and not associated with HIV infection. PloS one. 2011;6(1):e16130.
Ministry of Health NTaLP. NTLP June 2017- July 2018- Annual Report 2018 [Available from: https://www.health.go.ug/cause/national-tuberculosis-and-leprosy-division-july-2017-june-2018-report-december-2018/.
Ministry of Health NTaLP. Revised National Strategic Plan 2015/16 - 2019/20 2017 [Available from: https://ntrl.or.ug/wp-content/uploads/2017/09/Revised-NTLP-Stragetic-Plan-2015-2020_25th-Jul2017-final.pdf.
Minsitry of Health U. Addendum to the National Guidelines for the Programmatic Managemnt of Drug-Resistant Tuberculosis. June 2019.
Pan H, Bele S, Feng Y, Qiu S, Lü J, Tang S, et al. Analysis of the economic burden of diagnosis and treatment of tuberculosis patients in rural China. 2013;17(12):1575-80.
Mauch V, Melgen R, Marcelino B, Acosta I, Klinkenberg E, Suarez PJRPdSP. Tuberculosis patients in the Dominican Republic face severe direct and indirect costs and need social protection. 2013;33(5):332-9.
Minsitry of Health NTaL, Uganda. Addendum to the National Guidelines for the Programmatic Managemnt of Drug-Resistant Tuberculosis 2019 [Available from: http://library.health.go.ug/publications/tuberculosis/guidelines-programmatic-management-drug-resistant-tuberculosis.
Floyd K, Wilkinson D, Gilks CJB. Comparison of cost effectiveness of directly observed treatment (DOT) and conventionally delivered treatment for tuberculosis: experience from rural South Africa. 1997;315(7120):1407-11.
Khan M, Walley J, Witter S, Imran A, Safdar NJHp, planning. Costs and cost-effectiveness of different DOT strategies for the treatment of tuberculosis in Pakistan. 2002;17(2):178-86.
Loveday M, Wallengren K, Brust J, Roberts J, Voce A, Margot B, et al. Community-based care vs. centralised hospitalisation for MDR-TB patients, KwaZulu-Natal, South Africa. 2015;19(2):163-71.
Sinanovic E, Floyd K, Dudley L, Azevedo V, Grant R, Maher DJTijot, et al. Cost and cost-effectiveness of community-based care for tuberculosis in Cape Town, South Africa. 2003;7(9):S56-S62.
Makabayi-Mugabe R, Musaazi J, Zawedde-Muyanja S, Kizito E, Namwanje H, Aleu P, et al. Developing a patient-centered community-based model for management of multi-drug resistant tuberculosis in Uganda: a discrete choice experiment. BMC health services research. 2022;22(1):154.
Ministry of Health NTaLP, Uganda. National Guidelines for the programmatic Management of Drug-Resistant Tuberculosis 2016 [Available from: http://library.health.go.ug/publications/tuberculosis/guidelines-programmatic-management-drug-resistant-tuberculosis.
Mitnick C, Bayona J, Palacios E, Shin S, Furin J, Alcántara F, et al. Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru. The New England journal of medicine. 2003;348(2):119-28.
Williams AO, Makinde OA, Ojo M. Community-based management versus traditional hospitalization in treatment of drug-resistant tuberculosis: a systematic review and meta-analysis. Global health research and policy. 2016;1:10.
Wang HaC. 2007.
Zou G. A modified poisson regression approach to prospective studies with binary data. American journal of epidemiology. 2004;159(7):702-6.
Weiss P, Chen W, Cook VJ, Johnston JC. Treatment outcomes from community-based drug resistant tuberculosis treatment programs: a systematic review and meta-analysis. BMC infectious diseases. 2014;14:333.
Daru P, Matji R, AlMossawi HJ, Chakraborty K, Kak N. Decentralized, Community-Based Treatment for Drug-Resistant Tuberculosis: Bangladesh Program Experience. Global health, science and practice. 2018;6(3):594-602.
Kerschberger B, Telnov A, Yano N, Cox H, Zabsonre I, Kabore SM, et al. Successful expansion of community-based drug-resistant TB care in rural Eswatini - a retrospective cohort study. Tropical medicine & international health : TM & IH. 2019;24(10):1243-58.
Alipanah N, Jarlsberg L, Miller C, Linh NN, Falzon D, Jaramillo E, et al. Adherence interventions and outcomes of tuberculosis treatment: A systematic review and meta-analysis of trials and observational studies. 2018;15(7):e1002595.
World Health Organisation (WHO). Global Tuberculosis Report 2022 [Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022.
Pradipta IS, Forsman LD, Bruchfeld J, Hak E, Alffenaar JW. Risk factors of multidrug-resistant tuberculosis: A global systematic review and meta-analysis. The Journal of infection. 2018;77(6):469-78.
Baluku JB, Mukasa D, Bongomin F, Stadelmann A, Nuwagira E, Haller S, et al. Gender differences among patients with drug resistant tuberculosis and HIV co-infection in Uganda: a countrywide retrospective cohort study. BMC infectious diseases. 2021;21(1):1093.
Johnston JC, Shahidi NC, Sadatsafavi M, Fitzgerald JM. Treatment outcomes of multidrug-resistant tuberculosis: a systematic review and meta-analysis. PloS one. 2009;4(9):e6914.
Azeez A, Ndege J, Mutambayi R. Associated factors with unsuccessful tuberculosis treatment outcomes among tuberculosis/HIV coinfected patients with drug-resistant tuberculosis. International journal of mycobacteriology. 2018;7(4):347-54.
Chidambaram V, Tun NL, Majella MG, Ruelas Castillo J, Ayeh SK, Kumar A, et al. Male Sex Is Associated With Worse Microbiological and Clinical Outcomes Following Tuberculosis Treatment: A Retrospective Cohort Study, a Systematic Review of the Literature, and Meta-analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021;73(9):1580-8.
Moyo S, Cox HS, Hughes J, Daniels J, Synman L, De Azevedo V, et al. Loss from treatment for drug resistant tuberculosis: risk factors and patient outcomes in a community-based program in Khayelitsha, South Africa. PloS one. 2015;10(3):e0118919.
Mlondo MN, Melesse SF, Mwambi HGJTOPHJ. Risk Factors Associated with Tuberculosis Among Men; A Study of South Africa. 2022;15(1).
Burhan E, Soepandi PZ, Isbaniah F, Damayanti K, Edwar SQ, Maruli MF, et al. Determinants of treatment outcomes in patients with multidrug-resistant TB. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 2022;26(2):126-32.
Kang Y, Jo EJ, Eom JS, Kim MH, Lee K, Kim KU, et al. Treatment Outcomes of Patients with Multidrug-Resistant Tuberculosis: Comparison of Pre- and Post-Public-Private Mix Periods. Tuberculosis and respiratory diseases. 2021;84(1):74-83.
Zhang MW, Zhou L, Zhang Y, Chen B, Peng Y, Wang F, et al. Treatment outcomes of patients with multidrug and extensively drug-resistant tuberculosis in Zhejiang, China. European journal of medical research. 2021;26(1):31.
Yin J, Wang X, Zhou L, Wei X. The relationship between social support, treatment interruption and treatment outcome in patients with multidrug-resistant tuberculosis in China: a mixed-methods study. Tropical medicine & international health : TM & IH. 2018;23(6):668-77.
Muttamba W, Tumwebaze R, Mugenyi L, Batte C, Sekibira R, Nkolo A, et al. Households experiencing catastrophic costs due to tuberculosis in Uganda: magnitude and cost drivers. BMC public health. 2020;20(1):1409.
Dash M, Behera BP. Socioepidemiological status and clinical outcome of MDR TB patients in a tertiary medical college in Southern Odisha. Journal of family medicine and primary care. 2022;11(4):1275-81.
Myemba DT, Bwire GM, Sambayi G, Maganda BA, Njiro BJ, Ndumwa HP, et al. Clinical characteristics and treatment outcomes of patients with MDR tuberculosis in Dar Es Salaam region, Tanzania. JAC-antimicrobial resistance. 2020;2(4):dlaa108.
Samuels JP, Sood A, Campbell JR, Ahmad Khan F, Johnston JC. Comorbidities and treatment outcomes in multidrug resistant tuberculosis: a systematic review and meta-analysis. Scientific reports. 2018;8(1):4980.
Wu S, Zhang Y, Sun F, Chen M, Zhou L, Wang N, et al. Adverse Events Associated With the Treatment of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis. American journal of therapeutics. 2016;23(2):e521-30.

Table 1: Participants’ characteristics

No competing interests reported.

Community-based directly observed therapy is effective and results in better treatment outcomes for patients with multi-drug resistant tuberculosis in Uganda

Status:

Journal Publication

Version 1

Abstract

Figures

Background

Methods

Study design

Prospective arm

Retrospective arm

Study setting

Selection of community health workers to support community-based DOT

Roles of CHWs

Selection of study participants

Sample size determination

Study inclusion criteria

Study exclusion criteria

Data collection

Study Variables

Statistical Analysis

Results

Discussion

Conclusions

Abbreviations

Declarations

References

Tables

Additional Declarations

Supplementary Files

Status:

Journal Publication

Version 1