DOI: https://doi.org/10.21203/rs.3.rs-296527/v1
Background
Microalbuminuria is the main characteristic of Diabetic kidney disease (DKD), but it fluctuates greatly under the influence of blood glucose. Our aim was to establish some common clinical variables which could be easily collected to predict the risk of DKD in patients with type 2 diabetes.
Methods and results
We build an artificial intelligence (AI) model to quantitively predict the risk of DKD based on the biomedical parameters from 1239 patients. An information entropy-based feature selection method was applied to screen out the risk factors of DKD. The dataset was divided with 4/5 into the training set and 1/5 into the test set. By using the selected risk factors, 5-fold cross-validation is applied to train the prediction model and it finally got AUC of 0.72 and 0.71 in the training set and test set respectively. In addition, we provide a method of calculating risk factors’ contribution for individuals to provide personalized guidance for treatment. We set up web-based application available on http://www.cuilab.cn/dkd for self-check and early warning.
Conclusions
We establish a feasible prediction model for DKD and suggest the degree of risk contribution of each indicator for each individual, which has certain clinical significance for early intervention and prevention.
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