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Aalaa Mahgoub Albasha
Sudan University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9501-7264
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Objective Klebsiella pneumoniae (K. pneumoniae) involves both community-acquired and nosocomial infections. It is responsible for a wide variety of infections, including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. We constructed this study to detect several carbapenems resistant and virulence genes in classical and hyper-virulent strains of K. pneumoniae isolated from hospitalized neonates and adults in Khartoum state.
Results Seventy percent of the isolates were resistant to ceftazidime, 18(30%) to ciprofloxacin, 23(38.3%) to chloramphenicol, 24(40%) to gentamicin and 8% to imipenem, 35% were multidrug-resistant, and 7% extensively drug-resistant, all blood isolates (n=14) were resistant to ceftazidime. entB was the most predominant virulence gene (93.3%), followed by mrkD (78.3%), kfu (60%), K2 (51.7%), magA (18.3%) and rmpA (5%). blaOXA-48 was the most predominant carbapenem-resistant gene (68.3%), followed by blaNDM (10%), blaKPC (8.3%), and blaIMP (3.3%). Eight hyper-virulent strains were positive for blaOXA-48 and two for blaNDM genes.
Keywords
K. pneumoniae, MDR, XDR, hvKp, nosocomial infection and, Sudan,
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CURRENT STATUS: Published
View the published article at BMC Research Notes.
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Posted 09 Jun, 2020
No community comments so far
Editor assigned
On 04 Jun, 2020
Reviewers invited
Invitations sent on 04 Jun, 2020
Reviewer #1 agreed
On 04 Jun, 2020
Reviewer #2 agreed
On 04 Jun, 2020
Review #1 received
Received 04 Jun, 2020
Submission checks complete
On 03 Jun, 2020
Editor invited
On 03 Jun, 2020
No comments provided
Editorial decision: Major revision
On 29 May, 2020
Reviewer #2 agreed
On 28 May, 2020
Review #2 received
Received 28 May, 2020
Editor assigned
On 27 May, 2020
Reviewers invited
Invitations sent on 27 May, 2020
Reviewer #1 agreed
On 27 May, 2020
Review #1 received
Received 27 May, 2020
Submission checks complete
On 26 May, 2020
Editor invited
On 26 May, 2020
First submitted
On 24 May, 2020
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Subject Areas
Infectious Diseases
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A new preprint design is coming!
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See the published version of this preprint at BMC Research Notes.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
Aalaa Mahgoub Albasha
Sudan University of Science and Technology
Corresponding Author
ORCiD: https://orcid.org/0000-0002-9501-7264
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Research Notes.
Version 2
Posted 09 Jun, 2020
No community comments so far
Editor assigned
On 04 Jun, 2020
Reviewers invited
Invitations sent on 04 Jun, 2020
Reviewer #1 agreed
On 04 Jun, 2020
Reviewer #2 agreed
On 04 Jun, 2020
Review #1 received
Received 04 Jun, 2020
Submission checks complete
On 03 Jun, 2020
Editor invited
On 03 Jun, 2020
No comments provided
Editorial decision: Major revision
On 29 May, 2020
Reviewer #2 agreed
On 28 May, 2020
Review #2 received
Received 28 May, 2020
Editor assigned
On 27 May, 2020
Reviewers invited
Invitations sent on 27 May, 2020
Reviewer #1 agreed
On 27 May, 2020
Review #1 received
Received 27 May, 2020
Submission checks complete
On 26 May, 2020
Editor invited
On 26 May, 2020
First submitted
On 24 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Research Notes.
Objective Klebsiella pneumoniae (K. pneumoniae) involves both community-acquired and nosocomial infections. It is responsible for a wide variety of infections, including infections of the urinary tract, pneumonia, bacteremia, meningitis, wound infection and purulent abscesses. We constructed this study to detect several carbapenems resistant and virulence genes in classical and hyper-virulent strains of K. pneumoniae isolated from hospitalized neonates and adults in Khartoum state.
Results Seventy percent of the isolates were resistant to ceftazidime, 18(30%) to ciprofloxacin, 23(38.3%) to chloramphenicol, 24(40%) to gentamicin and 8% to imipenem, 35% were multidrug-resistant, and 7% extensively drug-resistant, all blood isolates (n=14) were resistant to ceftazidime. entB was the most predominant virulence gene (93.3%), followed by mrkD (78.3%), kfu (60%), K2 (51.7%), magA (18.3%) and rmpA (5%). blaOXA-48 was the most predominant carbapenem-resistant gene (68.3%), followed by blaNDM (10%), blaKPC (8.3%), and blaIMP (3.3%). Eight hyper-virulent strains were positive for blaOXA-48 and two for blaNDM genes.
Figure 1
This is a list of supplementary files associated with this preprint. Click to download.
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