Prolonged bleeding is a general complication that occurs after tooth extraction or oral surgery. Thus, patients must apply pressure and use absorbable wound dressings to stop bleeding and prevent blood loss. This method can stop bleeding and create blood clotting. However, some people have bleeding disorders or cannot stop bleeding with applied pressure after oral surgery. Therefore, hemostatic foam dressing has been an interesting material that can be used to stop bleeding and not damage blood clotting in the wound site. In this study, foam was prepared using a blend of starch with carboxymethyl chitosan and glyoxal as a crosslinking agent. The foam was formed by freeze-drying. Carboxymethyl chitosan/starch foam can absorb and hold water rapidly as analyzed by blood clotting assay and maximum swelling. Thus, carboxymethyl chitosan/starch foam (CM/starch foam) in a 1:4 ratio with 1% glyoxal can also absorb blood very well with suitable properties. It is non-cytotoxic to human dermal fibroblast cells by MTT assay and has good mechanical properties in a wet environment.