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Research article
The importance of sex as a risk factor for hospital readmissions due to pulmonary diseases
Alessandra Buja
Via Giustiniani 1
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2216-3807
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Public Health.
Background Pulmonary diseases are a common and costly cause of 30-day readmissions. Few studies have focused on the difference in risk for rehospitalization between men and women in older patients. In this study we analyzed the association between sex and the risk of readmission in a cohort of patients admitted to the hospital for chronic obstructive pulmonary disease (COPD) exacerbation and other major pulmonary diseases. Methods This was a retrospective cohort study based on administrative data collected in the Veneto Region in 2016. We included 14,869 hospital admissions among residents aged ≥ 65 years for diagnosis related groups (DRGs) of the most common disorders of the respiratory system: bronchitis and asthma, pneumonia, pulmonary edema, respiratory failure, and COPD. Multilevel logistic regressions were performed to test the association between 30-day hospital readmission and sex, adjusting for confounding factors. Results For bronchitis and asthma, male patients had significantly higher odds of 30-day readmission than female patients (adjusted odds ratio (aOR), 2.07; 95% confidence interval (CI), 1.11-3.87). The odds of readmission for men were also significantly higher for pneumonia (aOR, 1.40; 95% CI, 1.13-1.72), for pulmonary edema and respiratory failure (aOR, 1.28; 95% CI, 1.05-1.55), and for COPD (aOR, 1.34; 95% CI, 1.00-1.81). Conclusions This study found that male sex is a major risk factors for readmission in patients aged more than 65 years with a primary pulmonary diagnosis. More studies are needed to understand the underlying determinants of this phenomena and to provide targets for future interventions
Keywords
Pulmonary disease, readmission risk, sex differences, older people
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CURRENT STATUS: Published
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Posted 26 Dec, 2019
Published
On 14 Jan, 2020
No community comments so far
Editorial decision: Accept
On 27 Dec, 2019
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On 22 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 29 Nov, 2019
Reviewer #1 agreed
On 28 Nov, 2019
Review #1 received
Received 28 Nov, 2019
Editor assigned
On 27 Nov, 2019
Reviewers invited
Invitations sent on 27 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 12 Nov, 2019
Review #1 received
Received 29 Oct, 2019
Reviewer #1 agreed
On 28 Oct, 2019
Reviewers invited
Invitations sent on 27 Oct, 2019
Editor assigned
On 24 Oct, 2019
Submission checks complete
On 23 Oct, 2019
Editor invited
On 23 Oct, 2019
No comments provided
Reviewer #8 agreed
On 05 Aug, 2019
Review #2 received
Received 05 Aug, 2019
Editorial decision: Major revision
On 05 Aug, 2019
Reviewer #6 agreed
On 03 Aug, 2019
Reviewer #7 agreed
On 03 Aug, 2019
Reviewer #3 agreed
On 02 Aug, 2019
Reviewer #4 agreed
On 02 Aug, 2019
Reviewer #5 agreed
On 02 Aug, 2019
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Received 02 Aug, 2019
Reviewers invited
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On 01 Aug, 2019
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On 01 Aug, 2019
Review #1 received
Received 01 Aug, 2019
Submission checks complete
On 25 Jul, 2019
Editor assigned
On 21 Jul, 2019
Editor invited
On 20 Jul, 2019
First submitted
On 18 Jul, 2019
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This preprint is under consideration at BMC Public Health. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
The importance of sex as a risk factor for hospital readmissions due to pulmonary diseases
Alessandra Buja
Via Giustiniani 1
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2216-3807
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 4
Posted 26 Dec, 2019
Published
On 14 Jan, 2020
No community comments so far
Editorial decision: Accept
On 27 Dec, 2019
Submission checks complete
On 22 Dec, 2019
No comments provided
Editorial decision: Minor revision
On 29 Nov, 2019
Reviewer #1 agreed
On 28 Nov, 2019
Review #1 received
Received 28 Nov, 2019
Editor assigned
On 27 Nov, 2019
Reviewers invited
Invitations sent on 27 Nov, 2019
Submission checks complete
On 26 Nov, 2019
Editor invited
On 26 Nov, 2019
No comments provided
Editorial decision: Minor revision
On 12 Nov, 2019
Review #1 received
Received 29 Oct, 2019
Reviewer #1 agreed
On 28 Oct, 2019
Reviewers invited
Invitations sent on 27 Oct, 2019
Editor assigned
On 24 Oct, 2019
Submission checks complete
On 23 Oct, 2019
Editor invited
On 23 Oct, 2019
No comments provided
Reviewer #8 agreed
On 05 Aug, 2019
Review #2 received
Received 05 Aug, 2019
Editorial decision: Major revision
On 05 Aug, 2019
Reviewer #6 agreed
On 03 Aug, 2019
Reviewer #7 agreed
On 03 Aug, 2019
Reviewer #3 agreed
On 02 Aug, 2019
Reviewer #4 agreed
On 02 Aug, 2019
Reviewer #5 agreed
On 02 Aug, 2019
Review #3 received
Received 02 Aug, 2019
Reviewers invited
Invitations sent on 01 Aug, 2019
Reviewer #1 agreed
On 01 Aug, 2019
Reviewer #2 agreed
On 01 Aug, 2019
Review #1 received
Received 01 Aug, 2019
Submission checks complete
On 25 Jul, 2019
Editor assigned
On 21 Jul, 2019
Editor invited
On 20 Jul, 2019
First submitted
On 18 Jul, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Public Health.
Background Pulmonary diseases are a common and costly cause of 30-day readmissions. Few studies have focused on the difference in risk for rehospitalization between men and women in older patients. In this study we analyzed the association between sex and the risk of readmission in a cohort of patients admitted to the hospital for chronic obstructive pulmonary disease (COPD) exacerbation and other major pulmonary diseases. Methods This was a retrospective cohort study based on administrative data collected in the Veneto Region in 2016. We included 14,869 hospital admissions among residents aged ≥ 65 years for diagnosis related groups (DRGs) of the most common disorders of the respiratory system: bronchitis and asthma, pneumonia, pulmonary edema, respiratory failure, and COPD. Multilevel logistic regressions were performed to test the association between 30-day hospital readmission and sex, adjusting for confounding factors. Results For bronchitis and asthma, male patients had significantly higher odds of 30-day readmission than female patients (adjusted odds ratio (aOR), 2.07; 95% confidence interval (CI), 1.11-3.87). The odds of readmission for men were also significantly higher for pneumonia (aOR, 1.40; 95% CI, 1.13-1.72), for pulmonary edema and respiratory failure (aOR, 1.28; 95% CI, 1.05-1.55), and for COPD (aOR, 1.34; 95% CI, 1.00-1.81). Conclusions This study found that male sex is a major risk factors for readmission in patients aged more than 65 years with a primary pulmonary diagnosis. More studies are needed to understand the underlying determinants of this phenomena and to provide targets for future interventions