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Research article
Yong Sun
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3648-5308
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic.
Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains.
Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene.
Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.
Keywords
Coronavirus, SARS-CoV-2, Cluster, Asymptomatic case, Spike gene
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CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Submission checks complete
On 19 Nov, 2020
Editorial decision: Accept
On 10 Nov, 2020
No comments provided
Submission checks complete
On 30 Oct, 2020
Editorial decision: Minor revision
On 29 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 16 Oct, 2020
Editor assigned
On 29 Sep, 2020
Submission checks complete
On 28 Sep, 2020
Editor invited
On 28 Sep, 2020
Version 1
Posted 08 Jun, 2020
No comments provided
Editorial decision: Major revision
On 15 Sep, 2020
Review #2 received
Received 19 Jul, 2020
Review #1 received
Received 19 Jul, 2020
Reviewer #2 agreed
On 24 Jun, 2020
Reviewer #1 agreed
On 20 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
First submitted
On 19 May, 2020
Editor assigned
On 19 May, 2020
Submission checks complete
On 18 May, 2020
Editor invited
On 18 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Yong Sun
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3648-5308
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
No community comments so far
Submission checks complete
On 19 Nov, 2020
Editorial decision: Accept
On 10 Nov, 2020
No comments provided
Submission checks complete
On 30 Oct, 2020
Editorial decision: Minor revision
On 29 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 16 Oct, 2020
Editor assigned
On 29 Sep, 2020
Submission checks complete
On 28 Sep, 2020
Editor invited
On 28 Sep, 2020
Version 1
Posted 08 Jun, 2020
No comments provided
Editorial decision: Major revision
On 15 Sep, 2020
Review #2 received
Received 19 Jul, 2020
Review #1 received
Received 19 Jul, 2020
Reviewer #2 agreed
On 24 Jun, 2020
Reviewer #1 agreed
On 20 Jun, 2020
Reviewers invited
Invitations sent on 17 Jun, 2020
First submitted
On 19 May, 2020
Editor assigned
On 19 May, 2020
Submission checks complete
On 18 May, 2020
Editor invited
On 18 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background: COVID-19 is a newly emerging disease caused by a novel coronavirus (SARS-CoV-2), which spread globally in early 2020. Asymptomatic carriers of the virus contribute to the propagation of this disease, and the existence of asymptomatic infection has caused widespread fear and concern in the control of this pandemic.
Methods: In this study, we investigated the origin and transmission route of SARS-CoV-2 in Anhui’s two clusters, analyzed the role and infectiousness of asymptomatic patients in disease transmission, and characterized the complete spike gene sequences in the Anhui strains.
Results: We conducted an epidemiological investigation of two clusters caused by asymptomatic infections sequenced the spike gene of viruses isolated from 12 patients. All cases of the two clusters we investigated had clear contact histories, both from Wuhan, Hubei province. The viruses isolated from two outbreaks in Anhui were found to show a genetically close link to the virus from Wuhan. In addition, new single nucleotide variations were discovered in the spike gene.
Conclusions: Both clusters may have resulted from close contact and droplet-spreading and asymptomatic infections were identified as the initial cause. We also analyzed the infectiousness of asymptomatic cases and the challenges to the current epidemic to provided information for the development of control strategies.
Figure 1
Figure 2
Figure 3
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