Landslide is a type of slope processes causing a plethora of economic damage and loss of lives worldwide every year. This study aimed to analyze spatial landslide susceptibility mapping in the Khalkhal-Tarom Basin by integrating an adaptive neuro-fuzzy inference system (ANFIS) with two multi-criteria decision-making approaches, i.e. the stepwise weight assessment ratio analysis (SWARA) and the new best-worst method (BWM) techniques. For this purpose, the first step was to prepare a landslide inventory map, which were then divided randomly by the ratio of 30/70 for model training and validation. Thirteen conditioning factors were used as slope angle, slope aspect, altitude, topographic wetness index (TWI), plan curvature, profile curvature, distance to roads, distance to streams, distance to faults, lithology, land use, rainfall and normalized difference vegetation index (NDVI). After the database was created, the BWM and the SWARA methods were utilized to determine the relationships between the sub-criteria and landslides. Finally, landslide susceptibility maps were generated by implementing ANFIS-SWARA and ANFIS-BWM hybrid models, and the ROC curve was employed to appraise the predictive accuracy of each model. The results showed that the areas under curves (AUC) for the ANFIS-SWARA and ANFIS-BWM models were 73.6% and 75% respectively, and that the novel BWM yielded more realistic relationships between effective factors and the landslides. As a result, it was more efficient in training the ANFIS. Evidently, the generated landslide susceptibility maps (LSMs) can be very efficient in managing land use and preventing the damage caused by the landslide phenomenon.