This preprint is under consideration at Supportive Care in Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yumei Li
Tongji University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7275-1792
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To investigate the status of symptom clusters and mood states and analyze the correlation between them in patients with stage-IV lung cancer undergoing immunotherapy.
Methods: Using a convenience sampling method, we selected 259 patients for analysis with stage-IV lung cancer who were admitted to the oncology department of a hospital for immunotherapy from February to December 2020. Three instruments were used: a general situation questionnaire, the Chinese version of the M. D. Anderson Symptom Inventory, and the Brief Profile of Mood State Short Form.
Results: An exploratory factor analysis identified three main symptom clusters: the disturbance influence, general, and pain–fatigue related symptom clusters. The total score for mood state was (25.71 SD: ±8.32). The score of the depression dimension was the highest (3.30 ±1.85) in the negative mood state; the total score of mood state and the score of negative mood state at different latitudes were significantly positively correlated with the total score of symptom clusters (r = 0.420–0.529, p < 0.01).
Conclusion: There are many symptom clusters in patients with lung cancer undergoing immunotherapy. The negative mood state is significant and changes along with changes in symptom clusters; moreover, there is high correlation between them. There should be more focus on the evaluation and management of symptom clusters of patients in nursing to improve the patients’ quality of life.
Keywords
lung cancer, immunotherapy, mood state, symptom clusters
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Posted 26 Mar, 2021
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This preprint is under consideration at Supportive Care in Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Yumei Li
Tongji University
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7275-1792
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 26 Mar, 2021
No community comments so far
Reviewers invited
Invitations sent on 22 Mar, 2021
Editor assigned
On 04 Mar, 2021
First submitted
On 04 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cancer Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To investigate the status of symptom clusters and mood states and analyze the correlation between them in patients with stage-IV lung cancer undergoing immunotherapy.
Methods: Using a convenience sampling method, we selected 259 patients for analysis with stage-IV lung cancer who were admitted to the oncology department of a hospital for immunotherapy from February to December 2020. Three instruments were used: a general situation questionnaire, the Chinese version of the M. D. Anderson Symptom Inventory, and the Brief Profile of Mood State Short Form.
Results: An exploratory factor analysis identified three main symptom clusters: the disturbance influence, general, and pain–fatigue related symptom clusters. The total score for mood state was (25.71 SD: ±8.32). The score of the depression dimension was the highest (3.30 ±1.85) in the negative mood state; the total score of mood state and the score of negative mood state at different latitudes were significantly positively correlated with the total score of symptom clusters (r = 0.420–0.529, p < 0.01).
Conclusion: There are many symptom clusters in patients with lung cancer undergoing immunotherapy. The negative mood state is significant and changes along with changes in symptom clusters; moreover, there is high correlation between them. There should be more focus on the evaluation and management of symptom clusters of patients in nursing to improve the patients’ quality of life.
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