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Research Article
Mohammad Hassan Meshkibaf
Fasa University of Medical Science
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2646-8504
Reza Ahmadi
Shahrekord University of Medical Science
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose
Fluoxetine by increasing free radicals can cause hepatotoxicity. Ellagic acid and taurine have antioxidant properties. In this study, the protective effects of ellagic acid and taurine against fluoxetine-induced liver damage were examined
Methods
The animals were divided into five groups as follows: group 1: controls receiving corn oil; group 2: receiving fluoxetine 15 mg/kg body weight (bw); group 3: receiving fluoxetine 15mg/kg bw and ellagic acid 50 mg/kg bw; group 4: receiving fluoxetine 15 mg/kg bw and taurine 100 mg/kg bw; and group 5: receiving 15mg/kg bw, ellagic acid 50 mg/kg bw, and taurine 100 mg/kg bw.
Results
Fluoxetine significantly raised serum uric acid, malondialdehyde (MDA), protein carbonyl (PC), lipids profile, serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT), alkaline phosphatase (ALP), total bilirubin, and serum interleukin-1 beta; and gene expressions of interleukin-1beta (IL-1B), nuclear factor kappa B (NF-κB), and tumor necrosis factor-alpha (TNF-α). Moreover, it significantly decreased (p < 0.05) high-density lipoprotein cholesterol (HDL-C), ferric reducing/antioxidant power (FRAP), catalase (CAT), vitamin C, and superoxide dismutase (SOD) in the liver compared to group 1. Treatment with ellagic acid and taurine significantly elevated antioxidant capacity and decreased hepatotoxic biochemical parameters and cells’ inflammation compared to group 2. Also, the results confirm that treatment with ellagic acid and taurine improved tissue change and liver function.
Conclusion
Our study has concluded the beneficial effect of ellagic acid and taurine against fluoxetine-induced hepatotoxicity. This effect is derived from free radical scavenging properties and the anti-inflammatory effect related to IL-1B, NF-κB, TNF-α.
Keywords
Ellagic acid, Fluoxetine, Hepatoprotective, Oxidative stress, Taurine
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A new preprint design is coming!
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research Article
Mohammad Hassan Meshkibaf
Fasa University of Medical Science
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2646-8504
Reza Ahmadi
Shahrekord University of Medical Science
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
The most recent version of this article is available here.
No community comments so far
Version 1
Posted 23 Mar, 2021
No comments provided
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The most recent version of this article is available here.
Purpose
Fluoxetine by increasing free radicals can cause hepatotoxicity. Ellagic acid and taurine have antioxidant properties. In this study, the protective effects of ellagic acid and taurine against fluoxetine-induced liver damage were examined
Methods
The animals were divided into five groups as follows: group 1: controls receiving corn oil; group 2: receiving fluoxetine 15 mg/kg body weight (bw); group 3: receiving fluoxetine 15mg/kg bw and ellagic acid 50 mg/kg bw; group 4: receiving fluoxetine 15 mg/kg bw and taurine 100 mg/kg bw; and group 5: receiving 15mg/kg bw, ellagic acid 50 mg/kg bw, and taurine 100 mg/kg bw.
Results
Fluoxetine significantly raised serum uric acid, malondialdehyde (MDA), protein carbonyl (PC), lipids profile, serum glutamate pyruvate transaminase (GPT), serum glutamate oxaloacetate transaminase (GOT), alkaline phosphatase (ALP), total bilirubin, and serum interleukin-1 beta; and gene expressions of interleukin-1beta (IL-1B), nuclear factor kappa B (NF-κB), and tumor necrosis factor-alpha (TNF-α). Moreover, it significantly decreased (p < 0.05) high-density lipoprotein cholesterol (HDL-C), ferric reducing/antioxidant power (FRAP), catalase (CAT), vitamin C, and superoxide dismutase (SOD) in the liver compared to group 1. Treatment with ellagic acid and taurine significantly elevated antioxidant capacity and decreased hepatotoxic biochemical parameters and cells’ inflammation compared to group 2. Also, the results confirm that treatment with ellagic acid and taurine improved tissue change and liver function.
Conclusion
Our study has concluded the beneficial effect of ellagic acid and taurine against fluoxetine-induced hepatotoxicity. This effect is derived from free radical scavenging properties and the anti-inflammatory effect related to IL-1B, NF-κB, TNF-α.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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