See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
Research article
Hongmei Liu
Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, P.R.China Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, P.R.
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0641-7611
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Four-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) is the preferred way for evaluating fallopian tubal patency and it associated with higher rate of spontaneous conception. However, Few studies have evaluated the influencing factors of spontaneous conception in 4D-HyCoSy and suggested ways to choose treatment options after 4D-HyCoSy. The study was to evaluate the correlation between spontaneous conception outcome and the patients’ clinical characteristics as well as tubal patency in infertile women to provide reference on ways to manage the patient after 4D-HyCoSy.
Methods: This was a retrospective study and analysis of two hundred and eighty three (283) infertile patients who underwent a 4D-HyCoSy between December 2014 and October 2017 in our center. Eligible patients were those whose partners semen parameters were normal when based on World Health Organization(WHO) criteria, and had spontaneous conception without clinical interventions after 4D-HyCoSy.
Result(s): One hundred and sixteen patients (40.9%) conceived spontaneously and the mean conception time was (8.8 ± 0.3) months. Within a year after 4D-HyCoSy, the spontaneous conception rate was highest in type VI(62.5%), followed by type IV (46.2%), type III (44.4%), type V (39.4%), type II (33.9%) and type I (14.8%). With Cox regression analysis, two factors associated with spontaneous conception outcome appeared to increase spontaneous conception rate: patients with type IV or type VI tubes and duration of infertility less than 2 years. The age, type of infertility, multiparas, history of pelvic surgery, history of uterine cavity operation, uterine fibromyomata and polycystic ovary were unrelated to spontaneous conception outcome after 4D-HyCoSy.
Conclusion(s): This study showed that some infertile women could succeed in spontaneous conception after 4D-HyCoSy. Hence, We recommend the usage of 4D-HyCoSy as first line for tubal patency test and infertile patients should be advised to accept 4D-HyCoSy examination as soon as possible. Expectant treatment of about 8-9 months is reported to be feasible for infertile women whose 4D-HyCoSy findings showed one tube patency or poor patency. Alternatively, an immediate clinical intervention is recommended for those with bilateral obstructed tubes .
Keywords
Spontaneous Conception, Infertility, Tubal Patency, Hysterosalpingo Contrast, Sonography
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Submission checks complete
On 06 Oct, 2020
Editorial decision: Accept
On 05 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 29 Sep, 2020
Editor assigned
On 27 Sep, 2020
Editor invited
On 26 Sep, 2020
Submission checks complete
On 26 Sep, 2020
Version (no preprint)
Posted 29 Sep, 2020
Editor assigned
On 01 Oct, 2020
Submission checks complete
On 30 Sep, 2020
Editor invited
On 30 Sep, 2020
This version was not preprinted
No comments provided
Editorial decision: Major revision
On 02 Sep, 2020
Editor assigned
On 01 Sep, 2020
Submission checks complete
On 31 Aug, 2020
Editor invited
On 31 Aug, 2020
Version 2
Posted 06 Aug, 2020
No comments provided
Editorial decision: Major revision
On 10 Aug, 2020
Editor assigned
On 03 Aug, 2020
Editor invited
On 02 Aug, 2020
Submission checks complete
On 30 Jul, 2020
No comments provided
Review #1 received
Received 09 Jul, 2020
Editorial decision: Major revision
On 09 Jul, 2020
Review #2 received
Received 26 Jun, 2020
Reviewer #2 agreed
On 25 Jun, 2020
Reviewer #1 agreed
On 15 Jun, 2020
Reviewers invited
Invitations sent on 10 Jun, 2020
First submitted
On 18 May, 2020
Editor assigned
On 18 May, 2020
Submission checks complete
On 17 May, 2020
Editor invited
On 17 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
Learn more about our company.
A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Pregnancy and Childbirth.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Hongmei Liu
Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, P.R.China Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, P.R.
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0641-7611
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pregnancy and Childbirth.
No community comments so far
Submission checks complete
On 06 Oct, 2020
Editorial decision: Accept
On 05 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 29 Sep, 2020
Editor assigned
On 27 Sep, 2020
Editor invited
On 26 Sep, 2020
Submission checks complete
On 26 Sep, 2020
Version (no preprint)
Posted 29 Sep, 2020
Editor assigned
On 01 Oct, 2020
Submission checks complete
On 30 Sep, 2020
Editor invited
On 30 Sep, 2020
This version was not preprinted
No comments provided
Editorial decision: Major revision
On 02 Sep, 2020
Editor assigned
On 01 Sep, 2020
Submission checks complete
On 31 Aug, 2020
Editor invited
On 31 Aug, 2020
Version 2
Posted 06 Aug, 2020
No comments provided
Editorial decision: Major revision
On 10 Aug, 2020
Editor assigned
On 03 Aug, 2020
Editor invited
On 02 Aug, 2020
Submission checks complete
On 30 Jul, 2020
No comments provided
Review #1 received
Received 09 Jul, 2020
Editorial decision: Major revision
On 09 Jul, 2020
Review #2 received
Received 26 Jun, 2020
Reviewer #2 agreed
On 25 Jun, 2020
Reviewer #1 agreed
On 15 Jun, 2020
Reviewers invited
Invitations sent on 10 Jun, 2020
First submitted
On 18 May, 2020
Editor assigned
On 18 May, 2020
Submission checks complete
On 17 May, 2020
Editor invited
On 17 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Maternal & Fetal Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pregnancy and Childbirth.
Background: Four-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) is the preferred way for evaluating fallopian tubal patency and it associated with higher rate of spontaneous conception. However, Few studies have evaluated the influencing factors of spontaneous conception in 4D-HyCoSy and suggested ways to choose treatment options after 4D-HyCoSy. The study was to evaluate the correlation between spontaneous conception outcome and the patients’ clinical characteristics as well as tubal patency in infertile women to provide reference on ways to manage the patient after 4D-HyCoSy.
Methods: This was a retrospective study and analysis of two hundred and eighty three (283) infertile patients who underwent a 4D-HyCoSy between December 2014 and October 2017 in our center. Eligible patients were those whose partners semen parameters were normal when based on World Health Organization(WHO) criteria, and had spontaneous conception without clinical interventions after 4D-HyCoSy.
Result(s): One hundred and sixteen patients (40.9%) conceived spontaneously and the mean conception time was (8.8 ± 0.3) months. Within a year after 4D-HyCoSy, the spontaneous conception rate was highest in type VI(62.5%), followed by type IV (46.2%), type III (44.4%), type V (39.4%), type II (33.9%) and type I (14.8%). With Cox regression analysis, two factors associated with spontaneous conception outcome appeared to increase spontaneous conception rate: patients with type IV or type VI tubes and duration of infertility less than 2 years. The age, type of infertility, multiparas, history of pelvic surgery, history of uterine cavity operation, uterine fibromyomata and polycystic ovary were unrelated to spontaneous conception outcome after 4D-HyCoSy.
Conclusion(s): This study showed that some infertile women could succeed in spontaneous conception after 4D-HyCoSy. Hence, We recommend the usage of 4D-HyCoSy as first line for tubal patency test and infertile patients should be advised to accept 4D-HyCoSy examination as soon as possible. Expectant treatment of about 8-9 months is reported to be feasible for infertile women whose 4D-HyCoSy findings showed one tube patency or poor patency. Alternatively, an immediate clinical intervention is recommended for those with bilateral obstructed tubes .
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Loading...