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Research article
The Investigation Of The Effect Of Hyperglycaemic Changes On Psychophysical Measurements Of Visual Function In Pseudophakic People Living With Diabetes Mellitus.
Lindokuhle Majola
Department of Health
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5748-1584
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Phakic people living with diabetes mellitus (PDM) have been known to complain of transient subjective visual disturbances, however it has yet to be shown if this can extended to pseuodphakia as well. The measurement of visual acuity (VA) and contrast sensitivity (CS) forms part for these visual disturbances and is regarded as psychophysical measurements of vision. The purpose of this study was to show the effect of increasing blood glucose level (BGL) on visual acuity and contrast sensitivity in pseudophakic PDM.
Methods
This was quasi-experimental, quantitative study using a pretest-posttest approach. The study was conducted at Gamalakhe community health centre and included a sample of 50 pseudophakic people living without diabetes mellitus (PWDM) and 50 pseudophakic-PDM. BGL as well as psychophysical measurements of visual function were measured pre-prandial and postprandial. VA was measured at distance (4 m) and near (40 cm) using LogMAR VA charts, CS was measured at 50 cm using Mars chart. Ethical permission was obtained before commencement of the study from Biomedical Research Ethics Committee (BREC) and KwaZulu-Natal Department of Health. The data collected was captured and subsequently analysed using the SPSS version 25. The Kruskal-Wallis Test and Wilcoxon Sign Ranked was used to compare changes within each group.
Results
Glycaemic changes observed had a mean increase of 2.06 ± 1.35 mmol/L and 1.08 ± 0.47 mmol/L in pseudophakia PDM and pseudophakic PWDM, respectively. A mean increase in CS of 0.01 ± 0.10 log units in PDM was found, however the independent T-Test showed this was insignificant between PDM and PWDM (p = 0.27). Mean increase in distance (0.01 ± 0.04 log units, p = 0.25) and near LogMAR VA (0.001 ± 0.01 log units, p = 0.32) for pseudophakic PDM was found, however the Mann-Whitney U-Test showed a statistically insignificant change p = 0.45 and p = 0.13 in distance and near VA respectively when compared to changes observed for pseudophakic PWDM.
Conclusions
Acute hyperglycaemic changes does not result in overall significant changes in visual acuity and contrast sensitivity in pseudophakic PDM for an increase in glycaemia of 2 mmol/L. However, the duration of DM may affect the CS in pseudophakic PDM without retinopathy who have had DM for greater than 10 years.
Keywords
diabetes mellitus, contrast sensitivity, visual acuity, pseudophakia
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This is a preprint. It has not completed peer review.
Research article
The Investigation Of The Effect Of Hyperglycaemic Changes On Psychophysical Measurements Of Visual Function In Pseudophakic People Living With Diabetes Mellitus.
Lindokuhle Majola
Department of Health
Corresponding Author
ORCiD: https://orcid.org/0000-0002-5748-1584
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 05 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Phakic people living with diabetes mellitus (PDM) have been known to complain of transient subjective visual disturbances, however it has yet to be shown if this can extended to pseuodphakia as well. The measurement of visual acuity (VA) and contrast sensitivity (CS) forms part for these visual disturbances and is regarded as psychophysical measurements of vision. The purpose of this study was to show the effect of increasing blood glucose level (BGL) on visual acuity and contrast sensitivity in pseudophakic PDM.
Methods
This was quasi-experimental, quantitative study using a pretest-posttest approach. The study was conducted at Gamalakhe community health centre and included a sample of 50 pseudophakic people living without diabetes mellitus (PWDM) and 50 pseudophakic-PDM. BGL as well as psychophysical measurements of visual function were measured pre-prandial and postprandial. VA was measured at distance (4 m) and near (40 cm) using LogMAR VA charts, CS was measured at 50 cm using Mars chart. Ethical permission was obtained before commencement of the study from Biomedical Research Ethics Committee (BREC) and KwaZulu-Natal Department of Health. The data collected was captured and subsequently analysed using the SPSS version 25. The Kruskal-Wallis Test and Wilcoxon Sign Ranked was used to compare changes within each group.
Results
Glycaemic changes observed had a mean increase of 2.06 ± 1.35 mmol/L and 1.08 ± 0.47 mmol/L in pseudophakia PDM and pseudophakic PWDM, respectively. A mean increase in CS of 0.01 ± 0.10 log units in PDM was found, however the independent T-Test showed this was insignificant between PDM and PWDM (p = 0.27). Mean increase in distance (0.01 ± 0.04 log units, p = 0.25) and near LogMAR VA (0.001 ± 0.01 log units, p = 0.32) for pseudophakic PDM was found, however the Mann-Whitney U-Test showed a statistically insignificant change p = 0.45 and p = 0.13 in distance and near VA respectively when compared to changes observed for pseudophakic PWDM.
Conclusions
Acute hyperglycaemic changes does not result in overall significant changes in visual acuity and contrast sensitivity in pseudophakic PDM for an increase in glycaemia of 2 mmol/L. However, the duration of DM may affect the CS in pseudophakic PDM without retinopathy who have had DM for greater than 10 years.
Figure 1
Figure 2