See the published version of this preprint at Journal of Parasitic Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Shimaa Abdel-Radi
Cairo University Faculty of Veterinary Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7856-8147
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Fascioliasis causes public health problems and economic losses all over the world. The present study aimed to evaluate the synergistic action between Viteselen (anti-oxidant) and specific anti-Fasciola drug (Triclalbendazole (TCBZ) for improvement body condition of F. gigantica naturally infected sheep with reference to some hematological and biochemical biomarkers in their sera. Animals were divided into five equal groups include G-1 as control non-infected animals, G-2 to G-5 are Fasciola naturally infected animals. G-2 is non-treated group, animals in G-3 were treated with TCBZ, animals in G-4 were injected by Viteselen and those in G-5 were treated by both TCBZ and Viteselen. The results revealed significant decrease in mean eggs in feces and F. gigantica circulating antigens (FCAg) in sera of TCBZ treated sheep after the 1st week post treatment. Complete disappearance of eggs from feces of drug treated groups was recorded at 21st d.p.t. While the value of FCAg decreased to negative at 14th d.p.t. The highest significant improvement (p < 0.05) in the estimated hematological parameters (RBCs, Hb and TLC), liver enzymes (AST and ALT), oxidative stress and antioxidant markers (TAC, MDA, SOD and GSH) and reproductive hormones (Progesterone and Estradiol) was recorded in animals in G-5 followed by G-3. While non-significant improvement was recorded in animals in G-4 in comparison with those in the control group. This improvement increased with increasing the time post treatment.
For conclusion; using of Viteselen in association with specific anti-parasitic drug improved the general health parameters and reproductive performance of the investigated sheep.
Keywords
Sheep, Fasciola, Antioxidant, Triclabendazol. Hematological, biochemical parameters
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View the published article at Journal of Parasitic Diseases.
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Posted 13 Jul, 2021
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Received 13 Jul, 2021
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On 12 Jul, 2021
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See the published version of this preprint at Journal of Parasitic Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Shimaa Abdel-Radi
Cairo University Faculty of Veterinary Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7856-8147
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Journal of Parasitic Diseases.
Version (no preprint)
Posted 13 Jul, 2021
Reviews received
Received 13 Jul, 2021
Reviewers invited
Invitations sent on 13 Jul, 2021
Editor assigned
On 12 Jul, 2021
First submitted
On 11 Jul, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Journal of Parasitic Diseases.
Fascioliasis causes public health problems and economic losses all over the world. The present study aimed to evaluate the synergistic action between Viteselen (anti-oxidant) and specific anti-Fasciola drug (Triclalbendazole (TCBZ) for improvement body condition of F. gigantica naturally infected sheep with reference to some hematological and biochemical biomarkers in their sera. Animals were divided into five equal groups include G-1 as control non-infected animals, G-2 to G-5 are Fasciola naturally infected animals. G-2 is non-treated group, animals in G-3 were treated with TCBZ, animals in G-4 were injected by Viteselen and those in G-5 were treated by both TCBZ and Viteselen. The results revealed significant decrease in mean eggs in feces and F. gigantica circulating antigens (FCAg) in sera of TCBZ treated sheep after the 1st week post treatment. Complete disappearance of eggs from feces of drug treated groups was recorded at 21st d.p.t. While the value of FCAg decreased to negative at 14th d.p.t. The highest significant improvement (p < 0.05) in the estimated hematological parameters (RBCs, Hb and TLC), liver enzymes (AST and ALT), oxidative stress and antioxidant markers (TAC, MDA, SOD and GSH) and reproductive hormones (Progesterone and Estradiol) was recorded in animals in G-5 followed by G-3. While non-significant improvement was recorded in animals in G-4 in comparison with those in the control group. This improvement increased with increasing the time post treatment.
For conclusion; using of Viteselen in association with specific anti-parasitic drug improved the general health parameters and reproductive performance of the investigated sheep.
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