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Research article
Nidhal Haj Salem
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1105-2749
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: We aim to study the epidemiological and pathological characteristics of sudden death in young, to determine the etiology of death and to purpose recommendations for prevention.
Methods: we performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir. A review of all autopsies performed during 28 years was done. In each case, clinical information and circumstances of death were obtained and a complete forensic autopsy and histological and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.
Results: we collected 137 cases of sudden death during studied period. The mean age of the studied population was 26.47 years. In 72.6% death was classified as cardiac death and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6% and from a neurological origin in 4.5%. The cause of sudden death in this group was not established in 9.5%.
Conclusion: there are several potential causes of sudden unexplained death such as structural abnormalities, ion channels abnormalities. Unexplained deaths, presumed to result from sudden primary arrhythmogenic causes, occur in young adult with structurally normal hearts. That underlying disease-causing genetic defects may be involved has clinical implications for family members. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.
Keywords
Legal medicine, Sudden death, young adult, autopsy, epidemiology, sudden cardiacdeath.
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CURRENT STATUS: Published
View the published article at BMC Public Health.
No community comments so far
Submission checks complete
On 05 Dec, 2020
Editorial decision: Accept
On 03 Dec, 2020
No comments provided
Editor assigned
On 08 Nov, 2020
Submission checks complete
On 08 Nov, 2020
Editor invited
On 08 Nov, 2020
No comments provided
Editorial decision: Major revision
On 31 Oct, 2020
Editor assigned
On 06 Oct, 2020
Submission checks complete
On 05 Oct, 2020
Editor invited
On 05 Oct, 2020
Version 1
Posted 01 Jul, 2020
No comments provided
Editorial decision: Major revision
On 12 Sep, 2020
Review #1 received
Received 03 Sep, 2020
Review #2 received
Received 02 Sep, 2020
Reviewer #1 agreed
On 11 Aug, 2020
Reviewer #2 agreed
On 11 Aug, 2020
Reviewers invited
Invitations sent on 16 Jul, 2020
Editor assigned
On 14 Jul, 2020
Submission checks complete
On 30 Jun, 2020
Editor invited
On 29 Jun, 2020
Metrics
Comments: 0
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at BMC Public Health.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Nidhal Haj Salem
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1105-2749
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Public Health.
No community comments so far
Submission checks complete
On 05 Dec, 2020
Editorial decision: Accept
On 03 Dec, 2020
No comments provided
Editor assigned
On 08 Nov, 2020
Submission checks complete
On 08 Nov, 2020
Editor invited
On 08 Nov, 2020
No comments provided
Editorial decision: Major revision
On 31 Oct, 2020
Editor assigned
On 06 Oct, 2020
Submission checks complete
On 05 Oct, 2020
Editor invited
On 05 Oct, 2020
Version 1
Posted 01 Jul, 2020
No comments provided
Editorial decision: Major revision
On 12 Sep, 2020
Review #1 received
Received 03 Sep, 2020
Review #2 received
Received 02 Sep, 2020
Reviewer #1 agreed
On 11 Aug, 2020
Reviewer #2 agreed
On 11 Aug, 2020
Reviewers invited
Invitations sent on 16 Jul, 2020
Editor assigned
On 14 Jul, 2020
Submission checks complete
On 30 Jun, 2020
Editor invited
On 29 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Public Health.
Background: We aim to study the epidemiological and pathological characteristics of sudden death in young, to determine the etiology of death and to purpose recommendations for prevention.
Methods: we performed a retrospective cohort study using autopsy data from the Department of Forensic Medicine of Monastir. A review of all autopsies performed during 28 years was done. In each case, clinical information and circumstances of death were obtained and a complete forensic autopsy and histological and toxicological investigations were performed. We have included all sudden death in persons aged between 18 years and 35 years.
Results: we collected 137 cases of sudden death during studied period. The mean age of the studied population was 26.47 years. In 72.6% death was classified as cardiac death and was due to ischemic heart disease in 32.32%. Sudden death was attributed to a pleuropulmonary cause in 7.4%, an abdominal cause in 6% and from a neurological origin in 4.5%. The cause of sudden death in this group was not established in 9.5%.
Conclusion: there are several potential causes of sudden unexplained death such as structural abnormalities, ion channels abnormalities. Unexplained deaths, presumed to result from sudden primary arrhythmogenic causes, occur in young adult with structurally normal hearts. That underlying disease-causing genetic defects may be involved has clinical implications for family members. Our findings suggest that prevention of sudden death among young adults under the age of 35 years should also focus on evaluation for causes not associated with structural heart disease.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
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