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Research article
Secondary organizing pneumonia associated with pulmonary tuberculosis: case series and review of the literature
Eun Jin Kim
Catholic University of Daegu School of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9791-8077
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Pulmonary Medicine.
Background: Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it has not been reported as a sequela of disseminated tuberculosis.
Methods: From January 2016 to December 2018, we identified six cases of tuberculosis-associated SOP in which Mycobacterium tuberculosis was revealed by microbiological examination; one of the cases was miliary tuberculosis.
Results: Of the six cases, 17% were positive for acid fast bacillus (AFB) stain, but 100% were positive for M. tuberculosis polymerase chain reaction (MTB PCR) and AFB culture. In all cases, transbronchial lung biopsy was performed and organizing pneumonia was confirmed pathologically. All survived after treatment with anti-tuberculosis therapy.
Conclusions: Even if a biopsy performed in cases with pneumonia showing slow improvement appears to suggest organizing pneumonia, the possibility of tuberculosis should always be kept in mind in areas with high tuberculosis prevalence. MTB PCR appears to be more helpful than AFB stain for the first diagnosis of SOP associated with pulmonary tuberculosis.
Keywords
tuberculosis, organizing pneumonia, transbronchial lung biopsy
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This preprint is under consideration at BMC Pulmonary Medicine. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Secondary organizing pneumonia associated with pulmonary tuberculosis: case series and review of the literature
Eun Jin Kim
Catholic University of Daegu School of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9791-8077
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Pulmonary Medicine.
Background: Secondary organizing pneumonia (SOP) is difficult to distinguish from cryptogenic organizing pneumonia (COP) considering various clinical situations. SOP caused by Mycobacterium tuberculosis is rare; indeed, it has not been reported as a sequela of disseminated tuberculosis.
Methods: From January 2016 to December 2018, we identified six cases of tuberculosis-associated SOP in which Mycobacterium tuberculosis was revealed by microbiological examination; one of the cases was miliary tuberculosis.
Results: Of the six cases, 17% were positive for acid fast bacillus (AFB) stain, but 100% were positive for M. tuberculosis polymerase chain reaction (MTB PCR) and AFB culture. In all cases, transbronchial lung biopsy was performed and organizing pneumonia was confirmed pathologically. All survived after treatment with anti-tuberculosis therapy.
Conclusions: Even if a biopsy performed in cases with pneumonia showing slow improvement appears to suggest organizing pneumonia, the possibility of tuberculosis should always be kept in mind in areas with high tuberculosis prevalence. MTB PCR appears to be more helpful than AFB stain for the first diagnosis of SOP associated with pulmonary tuberculosis.
Figure 1