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Research
Association between neck circumference and the risk of decreased estimated glomerular filtration rate in the general population of China: a cross-sectional study
Yiming Mu
Medical School of Chinese PLA, Beijing, China. Department of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, China
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3344-3540
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: The burden of chronic kidney disease is increasing substantially worldwide. Neck circumference (NC), an anthropometric index for upper-body adiposity, has been recognized as an indicator of cardiometabolic diseases. However, the association between NC and renal dysfunction has not been fully disclosed. The aim of this study was to investigate the association between NC and estimated glomerular filtration rate (eGFR) in the general population in China.
Methods: A total of 8805 participants (3322 men and 5483 women) were enrolled in this study. Logistic regression analysis was conducted to examine the association between NC and eGFR. The male and female subjects were divided into four groups according to the neck circumference quartiles. The primary outcome was defined as an eGFR ≤ 90 mL/min/1.73 m2.
Results: Logistic regression analysis revealed that in both sexes, higher neck circumference was significantly associated with a higher risk of decreased eGFR even after fully adjusting for age; other anthropometric indexes, including body mass index and waist to hip ratio; traditional risk factors for chronic kidney diseases; and sociologic risk factors (Quartile1 as a reference; the odds ratios [95% confidence intervals] were as follows: Quartile 2, 1.26[0.99-1.59]; Quartile 3, 1.40[1.07-1.83]; Quartile 4, 1.71[1.22-2.38] in men; Quartile 2, 1.14[0.95-1.37]; Quartile 3, 1.31[1.03-1.66]; Quartile 4, 1.32[1.04-1.68] in women.) Stratified analyses suggested that the association was significant among subjects with prediabetes and those with normal serum uric acid levels. When the subjects were stratified according to blood pressure or BMI, the association persisted among male subjects with abnormal blood pressure and was strengthened among male subjects who were overweight/obese, while the association disappeared among female subjects.
Conclusions: NC is independently associated with the risk of decreased eGFR in the general population in China, indicating that NC could contribute to renal dysfunction risk assessment.
Keywords
Obesity, Neck circumference, Renal dysfunction, Estimated glomerular filtration
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Research
Association between neck circumference and the risk of decreased estimated glomerular filtration rate in the general population of China: a cross-sectional study
Yiming Mu
Medical School of Chinese PLA, Beijing, China. Department of Endocrinology, The First Medical Center of Chinese PLA General Hospital, Beijing, China
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3344-3540
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 28 May, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The burden of chronic kidney disease is increasing substantially worldwide. Neck circumference (NC), an anthropometric index for upper-body adiposity, has been recognized as an indicator of cardiometabolic diseases. However, the association between NC and renal dysfunction has not been fully disclosed. The aim of this study was to investigate the association between NC and estimated glomerular filtration rate (eGFR) in the general population in China.
Methods: A total of 8805 participants (3322 men and 5483 women) were enrolled in this study. Logistic regression analysis was conducted to examine the association between NC and eGFR. The male and female subjects were divided into four groups according to the neck circumference quartiles. The primary outcome was defined as an eGFR ≤ 90 mL/min/1.73 m2.
Results: Logistic regression analysis revealed that in both sexes, higher neck circumference was significantly associated with a higher risk of decreased eGFR even after fully adjusting for age; other anthropometric indexes, including body mass index and waist to hip ratio; traditional risk factors for chronic kidney diseases; and sociologic risk factors (Quartile1 as a reference; the odds ratios [95% confidence intervals] were as follows: Quartile 2, 1.26[0.99-1.59]; Quartile 3, 1.40[1.07-1.83]; Quartile 4, 1.71[1.22-2.38] in men; Quartile 2, 1.14[0.95-1.37]; Quartile 3, 1.31[1.03-1.66]; Quartile 4, 1.32[1.04-1.68] in women.) Stratified analyses suggested that the association was significant among subjects with prediabetes and those with normal serum uric acid levels. When the subjects were stratified according to blood pressure or BMI, the association persisted among male subjects with abnormal blood pressure and was strengthened among male subjects who were overweight/obese, while the association disappeared among female subjects.
Conclusions: NC is independently associated with the risk of decreased eGFR in the general population in China, indicating that NC could contribute to renal dysfunction risk assessment.
Figure 1