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Research
Alamgeer
University of the Punjab
Corresponding Author
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Background: The present study was endeavored to validate the antihyperlipidemic potential of Salvia bucharica (Lamiaceae) in lipofundin induced hyperlipidemia in rabbits and fructose treated hyperlipidemic rats.
Method: Extract of Salvia bucharica and atorvastation (10 mg/kg) were given to the animals through oral route. At the end of study period, blood samples were taken for determination of lipid profile. Furthermore, thoracic aorta and liver were studied for vasorexalation and histopathological changes respectively.
Results: Salvia bucharica has shown dose dependent antihyperlipidemic activity with a significant (p < 0.05) decrease in the levels of total cholesterol, low density lipoprotein and triglycerides in both models. In addition, Studies performed on the isolated thoracic aorta and histolopathological studies on liver demonstrated that Salvia bucharica has endothelial dependent vasoprotective and hepatoprotective activity respectively as compared to fructose fed rats. The toxicity studies of Salvia bucharica revealed that plant extract is safer for oral use.
Conclusion Hence, it was suggested that Salvia bucharica has the therapeutic potential against dyslipidemia and vascular dysfunction.
Keywords
Hyperlipidemia, Salvia bucharica, vasorelaxation, toxicity study
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Alamgeer
University of the Punjab
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 09 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Clinical Pharmacology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The present study was endeavored to validate the antihyperlipidemic potential of Salvia bucharica (Lamiaceae) in lipofundin induced hyperlipidemia in rabbits and fructose treated hyperlipidemic rats.
Method: Extract of Salvia bucharica and atorvastation (10 mg/kg) were given to the animals through oral route. At the end of study period, blood samples were taken for determination of lipid profile. Furthermore, thoracic aorta and liver were studied for vasorexalation and histopathological changes respectively.
Results: Salvia bucharica has shown dose dependent antihyperlipidemic activity with a significant (p < 0.05) decrease in the levels of total cholesterol, low density lipoprotein and triglycerides in both models. In addition, Studies performed on the isolated thoracic aorta and histolopathological studies on liver demonstrated that Salvia bucharica has endothelial dependent vasoprotective and hepatoprotective activity respectively as compared to fructose fed rats. The toxicity studies of Salvia bucharica revealed that plant extract is safer for oral use.
Conclusion Hence, it was suggested that Salvia bucharica has the therapeutic potential against dyslipidemia and vascular dysfunction.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
This is a list of supplementary files associated with this preprint. Click to download.
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