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Research article
Jian-Qing He
Sichuan University West China Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0557-3089
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: As a main line of defense of the respiratory tract, the airway epithelium plays an important role in the pathogenesis of asthma. CDHR3 and EMSY were reported to be expressed in the human airway epithelium. Although previous genome-wide association studies found that the two genes were associated with asthma susceptibility, similar observations have not been made in the Chinese Han population.
Methods: A total of 300 asthma patients and 418 healthy controls unrelated Chinese Han individuals were enrolled. Tag-single nucleotide polymorphisms (Tag-SNPs) were genotyped and the associations between SNPs and asthma risk were analyzed by binary logistic regression analysis.
Results: After adjusting for confounding factors, the A allele of rs3847076 in CDHR3 was associated with increased susceptibility to asthma (OR = 1.407, 95% CI: 1.030-1.923). For the EMSY gene, the T alleles of both rs2508746 and rs12278256 were related with decreased susceptibility to asthma (additive model: OR = 0.718, 95% CI: 0.536-0.961; OR = 0.558, 95% CI: 0.332-0.937, respectively). In addition, the GG genotype of rs1892953 showed an association with increased asthma risk under the recessive model (OR = 1.667, 95% CI: 1.104-2.518) and the GATCTGAGT haplotype in EMSY was associated with reduced asthma risk ( P = 0.037).
Conclusions: This study identified novel associations of rs3847076 in CDHR3 , as well as rs1892953, rs2508746 and rs12278256 in EMSY with adult asthma susceptibility in the Chinese Han population. Our observations suggest that CDHR3 and EMSY may play important roles in the pathogenesis of asthma in Chinese individuals. Further study with larger sample size is needed.
Keywords
CDHR3, EMSY, asthma, polymorphism, susceptibility
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CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
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Editorial decision: Accept
On 01 Nov, 2020
Editor assigned
On 30 Oct, 2020
Submission checks complete
On 30 Oct, 2020
Editor invited
On 30 Oct, 2020
Version 3
Posted 22 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 19 Oct, 2020
Review #1 received
Received 17 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Reviewers invited
Invitations sent on 14 Oct, 2020
Editor assigned
On 14 Oct, 2020
Submission checks complete
On 13 Oct, 2020
Editor invited
On 13 Oct, 2020
No comments provided
Reviewers invited
Invitations sent on 16 Sep, 2020
Reviewer #1 agreed
On 16 Sep, 2020
Editor assigned
On 15 Sep, 2020
Submission checks complete
On 14 Sep, 2020
Editor invited
On 14 Sep, 2020
No comments provided
Review #1 received
Received 26 Jul, 2020
Editorial decision: Major revision
On 26 Jul, 2020
Reviewer #3 agreed
On 19 Jul, 2020
Review #3 received
Received 19 Jul, 2020
Review #2 received
Received 19 Jul, 2020
Reviewer #2 agreed
On 05 Jul, 2020
Reviewer #1 agreed
On 04 Jun, 2020
Reviewers invited
Invitations sent on 30 May, 2020
First submitted
On 22 May, 2020
Editor assigned
On 22 May, 2020
Submission checks complete
On 21 May, 2020
Editor invited
On 21 May, 2020
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Subject Areas
Pulmonology
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A new preprint design is coming!
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See the published version of this preprint at BMC Pulmonary Medicine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Jian-Qing He
Sichuan University West China Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-0557-3089
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Pulmonary Medicine.
No community comments so far
Editorial decision: Accept
On 01 Nov, 2020
Editor assigned
On 30 Oct, 2020
Submission checks complete
On 30 Oct, 2020
Editor invited
On 30 Oct, 2020
Version 3
Posted 22 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 19 Oct, 2020
Review #1 received
Received 17 Oct, 2020
Reviewer #1 agreed
On 16 Oct, 2020
Reviewers invited
Invitations sent on 14 Oct, 2020
Editor assigned
On 14 Oct, 2020
Submission checks complete
On 13 Oct, 2020
Editor invited
On 13 Oct, 2020
No comments provided
Reviewers invited
Invitations sent on 16 Sep, 2020
Reviewer #1 agreed
On 16 Sep, 2020
Editor assigned
On 15 Sep, 2020
Submission checks complete
On 14 Sep, 2020
Editor invited
On 14 Sep, 2020
No comments provided
Review #1 received
Received 26 Jul, 2020
Editorial decision: Major revision
On 26 Jul, 2020
Reviewer #3 agreed
On 19 Jul, 2020
Review #3 received
Received 19 Jul, 2020
Review #2 received
Received 19 Jul, 2020
Reviewer #2 agreed
On 05 Jul, 2020
Reviewer #1 agreed
On 04 Jun, 2020
Reviewers invited
Invitations sent on 30 May, 2020
First submitted
On 22 May, 2020
Editor assigned
On 22 May, 2020
Submission checks complete
On 21 May, 2020
Editor invited
On 21 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Pulmonology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Pulmonary Medicine.
Background: As a main line of defense of the respiratory tract, the airway epithelium plays an important role in the pathogenesis of asthma. CDHR3 and EMSY were reported to be expressed in the human airway epithelium. Although previous genome-wide association studies found that the two genes were associated with asthma susceptibility, similar observations have not been made in the Chinese Han population.
Methods: A total of 300 asthma patients and 418 healthy controls unrelated Chinese Han individuals were enrolled. Tag-single nucleotide polymorphisms (Tag-SNPs) were genotyped and the associations between SNPs and asthma risk were analyzed by binary logistic regression analysis.
Results: After adjusting for confounding factors, the A allele of rs3847076 in CDHR3 was associated with increased susceptibility to asthma (OR = 1.407, 95% CI: 1.030-1.923). For the EMSY gene, the T alleles of both rs2508746 and rs12278256 were related with decreased susceptibility to asthma (additive model: OR = 0.718, 95% CI: 0.536-0.961; OR = 0.558, 95% CI: 0.332-0.937, respectively). In addition, the GG genotype of rs1892953 showed an association with increased asthma risk under the recessive model (OR = 1.667, 95% CI: 1.104-2.518) and the GATCTGAGT haplotype in EMSY was associated with reduced asthma risk ( P = 0.037).
Conclusions: This study identified novel associations of rs3847076 in CDHR3 , as well as rs1892953, rs2508746 and rs12278256 in EMSY with adult asthma susceptibility in the Chinese Han population. Our observations suggest that CDHR3 and EMSY may play important roles in the pathogenesis of asthma in Chinese individuals. Further study with larger sample size is needed.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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