Substance use disorder (SUD) is defined as a pathological, chronic, and compulsive urge to consume psychoactive substances although they are hazardous to oneself and others (1). Addictive behaviors towards substance use such as the consumption of alcohol, nicotine, cannabis use and others, are widespread among the general population (2) and are associated with serious public health problems. Correspondingly, the World Drug Report (2) notes that 284 million people worldwide are currently affected by substance abuse and dependence. Younger generations typically report higher levels of substance use than adults. Moreover, substance use levels among young people is higher today than in previous generations. In addition, SUDs show significant comorbidities with a variety of psychiatric disorders (3). SUDs are considerably related to depression, anxiety disorder, bipolar and emotional dysregulation disorder (3, 4). In terms of the impact of emotions on the pathogenesis of addiction, recent advances in Affective Neuroscience (AN) propose specific dysregulations within primary emotions. According to Jaak Panksepp (5) primary emotions are a subcortically rooted affective systems that are thought to be evolutionarily innate, serving as the primary motivational system of behavior and are universal across cultures. The proposed seven basic emotional systems are evolutionary tools for survival and fitness in mammalian species and are located in the subcortical brain.
These primary emotions systems are called SEEKING, CARE, LUST, ANGER, PLAY, FEAR, PANIC/GRIEF (or SADNESS) (6). Based on their valence they can be roughly distinguished into a positive and a negative group (7). The positive group encompasses SEEKING, PLAY, CARE, and LUST, which collectively reside on the pleasurable end of the emotional spectrum. They play integral roles in accomplishing diverse life objectives, such as engaging with the external world (SEEKING), achieving reproduction (LUST), nurturing offspring (CARE) or fostering social connections (PLAY). In contrast FEAR, ANGER and SADNESS represent are unpleasurable primary emotions. The evolutionary use of these emotions is e.g. the avoidance of harm, overcoming of obstacles or aversion of loss. The negative emotions can be understood as an innate warning system (8).
The Affective Neuroscience Personality Scales (ANPS) were developed by Davis et al. (9) to measure primary emotions dispositions in individuals. Furthermore, Barrett et al. (10) developed a short version of the ANPS, defined as the BANPS. Most recently, Fuchshuber and Prandstätter et al. (11) developed The German Version of the Brief Affective Neuroscience Personality Scales including a LUST scale (BANPS–GL). Regarding the impact of primary emotions on the pathogenesis of SUDs recent studies emphasize dysregulations especially within the SEEKING, the SADNESS and the ANGER systems (12, 13).
The SEEKING network conveys positive feelings of curiosity and anticipation and curiosity and is consistent with Berridge's concept of "wanting” (14). In terms of the SEEKING system, addictive behavior is thought to be characterized by pathological alterations occurring within the SEEKING/mesolimbic dopamine system. Subsequently, addictive behavior is mediated by obsessive-compulsive behaviors, maintained by wanting/SEEKING circuits in the case of substance abuse, as well as consummatory-PLEASURE reactions, particularly in the case of opioid abuse (13). In turn, addictive behavior may eventually lead to the exhaustion of resources for reward seeking. This in turn causes a feeling of dysphoria that can only be relieved temporarily by substance abuse. However, this promotes a negative effect that perpetuates the addictive cycle. Finally, the SEEKING network is increasingly activated in relation to substance-related appetitive memories, substance use, and the drive to relieve negative affective states (15–17).
The ANGER system is described by the characteristic of feeling easily irritated, frustrated and aggressive, as well as the experience of being angry as a result of frustrations. The hypothesis that anger is related to addictive behavior is based on object relations theory, which views autoaggressive behavior as an ethiological factor in substance abuse (18). The results of Unterrainer et al. (2017) and Fuchshuber et al. (2019) support this assumption: Unterrainer et al. (19) were able to show increased SADNESS, FEAR and ANGER in substance abuse disorder patients. Employing a path analytical approach, Fuchshuber et al. (20) found associations between substance abuse, ANGER and SADNESS in a non-clinical sample.
The SADNESS system is triggered by the loss of a beloved object and consequently produces painful feelings of separation anxiety/distress and loneliness (21). The SADNESS system, which is also called the PANIC/GRIEF system, based on the panic phase of separation distress, e.g. when a child has lost the contact with his caregivers, but also due to his relation to "panic" attacks. This network is also activated in a similar way when a social/romantic relationship ends. When attachments are interrupted by loss or separation, the person feels "bad" in a special way. This particular type of social pain is referred to as "separation distress”. The SADNESS system is characterized by specific neurochemistry that has a central point in the endogenous opioid system (22). On this background, addiction might be seen as a dysfunctional attempt to regulate overwhelming feelings of loss, sadness, grief and isolation mediated by an overactive PANIC/GRIEF system.
Furthermore, the predominantly primary emotion systems, are considered as connected to secondary order processes, which includes attachment patterns in mammals (23). The development of attachment bonds, which is especially driven by the SADNESS system, and addictive behavior has strong similarities (24, 25). Those similarities shared by attachment and addiction involve social bonding and drug dependence, estrangement and drug tolerance as well as separation distress and drug withdrawal. As a result, addiction is frequently described as a deranged type of attachment (26). Attachment Theory, originally posited by John Bowlby (27) and subsequently refined by Mary Ainsworth (28), postulates that the development of forms of psychopathology in adolescence and young adulthood may be due, at least in part, to dysfunctional interactions with attachment figures and influences affect regulations. According to this theory, these are securely attached and two insecurely attached attachment patterns: Attachment anxiety - an overactive pattern - is defined by the fear of interpersonal rejection and the excessive search for closeness and recognition by others, combined with low self-confidence. On the contrary, attachment avoidance - a deactivation pattern - is associated with fears of closeness and interpersonal dependence (29).
There is a growing amount of empirical evidence linking adult attachment styles and addictive disorders (30, 31). A meta-analysis of 34 studies (N = 56,721) found significant associations linking insecure attachment and substance use (31). Insecure attachment style was found to predict the development of substance use problems and the association remained the same regardless of the kind of substance (e.g., alcohol, marijuana).
Regarding the association between addictive behavior and insecure attachment style, associations are found particularly with anxious attachment style. It is hypothesized that people who report stronger anxious attachment may turn to addictive behaviors to cope with emotional distress, whereas those with an avoidant style may not experience such emotional distress because of their strategies to deactivate emotions. Schindler et al. (32) found associations between attachment anxiety and substance use disorder as well as Unterrainer et al. (19) and Liese et al. (33).
A meta-analysis of 100 studies (N = 20,350) supporting the role of attachment and emotional dysregulation found that insecure attachment is consistently linked to lower emotion regulation skills than secure attachment (34). In fact, emotion dysregulation has been hypothesized to mediate the link between anxious (but not avoidant) attachment and alcohol problems (35).
Study aims
To further investigate the interactions between primary emotions, attachment anxiety and addictive behavior, this study examines whether the relationship between primary emotions and the tendency toward addictive behavior is mediated by an anxious attachment style. To our knowledge, no study has tested whether attachment anxiety mediates the relationship between specific primary emotions and addictive behavior.
In line with previous research we hypothesized that increased negative primary emotions (FEAR, ANGER, and SADNESS) and attachment anxiety are associated with addictive behavior. To assess the extent of how attachment anxiety mediates the association between primary emotions and addictive behavior, this study applied the structural equation modeling technique, which has the advantage of being able to estimate the relationship of multiple concepts simultaneously.