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Tenofovir Based First Line Therapy in Newly Diagnosed Case of HIV Infection: An Experience from a Tertiary Care Hospital in India
Arkapal Bandyopadhyay
All India Institute of Medical Sciences - Raipur
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9755-0233
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This work is licensed under a CC BY 4.0 License. Read Full License
Introduction: India has a huge burden of HIV/AIDS infection. Tenofovir based first line therapy is the preferred treatment for newly diagnosed cases with HIV infection.
Methodology: The present prospective study was done among newly diagnosed cases of HIV infection. The patients were followed up for a period of 6 months from the day of enrolment. Sociodemographic parameters, CD4 counts and adverse drug reactions were analysed at baseline and after 6 months. Bi-variate and multi-variate logistic regression was performed with the outcome variable as occurrence of adverse drug reactions.
Result: In this study, 67 patients were enrolled with mean age 32.75 (± 14.39) years. Mean CD4 count at start of treatment was 241.5/mm3. Mean difference in CD4 count was 383.05/mm3 (SD = 274.9). Dizziness, tingling, numbness of extremities and muscle cramps were most common adverse effects. On multi-variate logistic regression, occurrence of ADRs was seen to be significantly higher only in illiterate patients.
Conclusion: The present study highlights the importance of long-term follow-up of the patients on antiretroviral therapy. Adequate monitoring of the treatment parameters is of utmost importance.
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Research
Tenofovir Based First Line Therapy in Newly Diagnosed Case of HIV Infection: An Experience from a Tertiary Care Hospital in India
Arkapal Bandyopadhyay
All India Institute of Medical Sciences - Raipur
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9755-0233
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 01 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Health Economics & Outcomes Research
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Introduction: India has a huge burden of HIV/AIDS infection. Tenofovir based first line therapy is the preferred treatment for newly diagnosed cases with HIV infection.
Methodology: The present prospective study was done among newly diagnosed cases of HIV infection. The patients were followed up for a period of 6 months from the day of enrolment. Sociodemographic parameters, CD4 counts and adverse drug reactions were analysed at baseline and after 6 months. Bi-variate and multi-variate logistic regression was performed with the outcome variable as occurrence of adverse drug reactions.
Result: In this study, 67 patients were enrolled with mean age 32.75 (± 14.39) years. Mean CD4 count at start of treatment was 241.5/mm3. Mean difference in CD4 count was 383.05/mm3 (SD = 274.9). Dizziness, tingling, numbness of extremities and muscle cramps were most common adverse effects. On multi-variate logistic regression, occurrence of ADRs was seen to be significantly higher only in illiterate patients.
Conclusion: The present study highlights the importance of long-term follow-up of the patients on antiretroviral therapy. Adequate monitoring of the treatment parameters is of utmost importance.