See the published version of this preprint at Cardiovascular Diabetology.
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Original investigation
Huihui Bao
Nanchang University Second Affiliated Hospital
Corresponding Author
Xiaoshu Cheng
the Second Affiliated Hospital of Nanchang University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients.
Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV).
Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively correlated with baPWV (β, 0.97; 95% confidence interval [CI] 0.78, 1.17). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.03; 95% CI 1.70, 2.41). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).
Conclusion: TyG index was independently and positively correlated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.
Keywords
Triglyceride glucose index, Brachial-ankle pulse wave velocity, Arterial stiffness, Hypertension
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CURRENT STATUS: Published
View the published article at Cardiovascular Diabetology.
No community comments so far
Editor assigned
On 04 Sep, 2020
Editorial decision: Accept
On 04 Sep, 2020
Submission checks complete
On 03 Sep, 2020
Editor invited
On 03 Sep, 2020
Version 1
Posted 05 Jun, 2020
No comments provided
Editorial decision: Major Revision
On 28 Jun, 2020
Review #4 received
Received 27 Jun, 2020
Review #2 received
Received 25 Jun, 2020
Review #3 received
Received 23 Jun, 2020
Review #1 received
Received 15 Jun, 2020
Reviewer #4 agreed
On 05 Jun, 2020
Reviewer #3 agreed
On 05 Jun, 2020
Reviewers invited
Invitations sent on 04 Jun, 2020
Reviewer #1 agreed
On 04 Jun, 2020
Reviewer #2 agreed
On 04 Jun, 2020
Editor assigned
On 03 Jun, 2020
First submitted
On 02 Jun, 2020
Submission checks complete
On 02 Jun, 2020
Editor invited
On 02 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
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Subject Areas
Cardiac & Cardiovascular Systems
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
See the published version of this preprint at Cardiovascular Diabetology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Original investigation
Huihui Bao
Nanchang University Second Affiliated Hospital
Corresponding Author
Xiaoshu Cheng
the Second Affiliated Hospital of Nanchang University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at Cardiovascular Diabetology.
No community comments so far
Editor assigned
On 04 Sep, 2020
Editorial decision: Accept
On 04 Sep, 2020
Submission checks complete
On 03 Sep, 2020
Editor invited
On 03 Sep, 2020
Version 1
Posted 05 Jun, 2020
No comments provided
Editorial decision: Major Revision
On 28 Jun, 2020
Review #4 received
Received 27 Jun, 2020
Review #2 received
Received 25 Jun, 2020
Review #3 received
Received 23 Jun, 2020
Review #1 received
Received 15 Jun, 2020
Reviewer #4 agreed
On 05 Jun, 2020
Reviewer #3 agreed
On 05 Jun, 2020
Reviewers invited
Invitations sent on 04 Jun, 2020
Reviewer #1 agreed
On 04 Jun, 2020
Reviewer #2 agreed
On 04 Jun, 2020
Editor assigned
On 03 Jun, 2020
First submitted
On 02 Jun, 2020
Submission checks complete
On 02 Jun, 2020
Editor invited
On 02 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Cardiovascular Diabetology.
Background: Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients.
Methods: This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV).
Results: The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively correlated with baPWV (β, 0.97; 95% confidence interval [CI] 0.78, 1.17). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.03; 95% CI 1.70, 2.41). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05).
Conclusion: TyG index was independently and positively correlated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
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