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Case report
Hiromitsu Hatakeyama
Yokohama City University Medical Center: Yokohama Shiritsu Daigaku Fuzoku Shimin Sogo Iryo Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6068-5289
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Mycobacterium abscessus ssp. massiliense is a non-tuberculous mycobacteriosis and was subdivided from Mycobacterium abscessus in 2006. There are no reports to date on nasopharyngitis caused by Mycobacterium abscessus ssp. massiliense.
Case Presentation
A 45-year old woman was referred to Yokohama City University Medical Center with an 18-month history of recurrent nasopharyngitis and presented with pain in the throat. Mycobacterial tissue culture and polymerase chain reaction testing revealed the presence of Mycobacterium abscessus ssp. massiliense in the nasopharyngeal tissue. This patient underwent surgery, followed by multiple rounds of chemotherapy with oral and intravenous antibiotic agents for four months. She has had no recurrence during the 8 months since treatment.
Conclusion
There are few reports on Mycobacterium abscessus ssp. massiliense infection in the head and neck region, and none in the pharynx. To our knowledge, this is the first report of a patient with a nasopharyngeal Mycobacterium abscessus ssp. massiliense infection. It is difficult to prove the presence of Mycobacterium abscessus ssp. massiliense in a pharyngeal “swab,” and tissue culture from a biopsy specimen is mandatory for the identification of the species. Currently, no definite treatment policy is available and only empirical treatment is applied. Further reports are needed to accumulate supporting evidence.
Keywords
Mycobacterium massilliense, Mycobacterium abscessus ssp. massiliense, nasopharyngitis, non-Tuberculosis mycobacterium, NTM, Mycobacterium abscessus complex, case report
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CURRENT STATUS: Under Revision
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Posted 18 Mar, 2021
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Editorial decision: Major revision
On 05 Apr, 2021
Review #1 received
Received 30 Mar, 2021
Review #3 received
Received 28 Mar, 2021
Review #2 received
Received 24 Mar, 2021
Reviewer #3 agreed
On 19 Mar, 2021
Reviewer #2 agreed
On 18 Mar, 2021
Reviewer #1 agreed
On 16 Mar, 2021
Review #? received
Received 16 Mar, 2021
Reviewers invited
Invitations sent on 15 Mar, 2021
Editor assigned
On 11 Mar, 2021
Submission checks complete
On 11 Mar, 2021
Editor invited
On 11 Mar, 2021
First submitted
On 10 Mar, 2021
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Subject Areas
Otorhinolaryngology
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This preprint is under consideration at European Journal of Medical Research. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case report
Hiromitsu Hatakeyama
Yokohama City University Medical Center: Yokohama Shiritsu Daigaku Fuzoku Shimin Sogo Iryo Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-6068-5289
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 18 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 05 Apr, 2021
Review #1 received
Received 30 Mar, 2021
Review #3 received
Received 28 Mar, 2021
Review #2 received
Received 24 Mar, 2021
Reviewer #3 agreed
On 19 Mar, 2021
Reviewer #2 agreed
On 18 Mar, 2021
Reviewer #1 agreed
On 16 Mar, 2021
Review #? received
Received 16 Mar, 2021
Reviewers invited
Invitations sent on 15 Mar, 2021
Editor assigned
On 11 Mar, 2021
Submission checks complete
On 11 Mar, 2021
Editor invited
On 11 Mar, 2021
First submitted
On 10 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Otorhinolaryngology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Mycobacterium abscessus ssp. massiliense is a non-tuberculous mycobacteriosis and was subdivided from Mycobacterium abscessus in 2006. There are no reports to date on nasopharyngitis caused by Mycobacterium abscessus ssp. massiliense.
Case Presentation
A 45-year old woman was referred to Yokohama City University Medical Center with an 18-month history of recurrent nasopharyngitis and presented with pain in the throat. Mycobacterial tissue culture and polymerase chain reaction testing revealed the presence of Mycobacterium abscessus ssp. massiliense in the nasopharyngeal tissue. This patient underwent surgery, followed by multiple rounds of chemotherapy with oral and intravenous antibiotic agents for four months. She has had no recurrence during the 8 months since treatment.
Conclusion
There are few reports on Mycobacterium abscessus ssp. massiliense infection in the head and neck region, and none in the pharynx. To our knowledge, this is the first report of a patient with a nasopharyngeal Mycobacterium abscessus ssp. massiliense infection. It is difficult to prove the presence of Mycobacterium abscessus ssp. massiliense in a pharyngeal “swab,” and tissue culture from a biopsy specimen is mandatory for the identification of the species. Currently, no definite treatment policy is available and only empirical treatment is applied. Further reports are needed to accumulate supporting evidence.
Figure 1
Figure 2
Figure 3
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