Network Pharmacology study of Curcuma longa L.: Potential Target Proteins and their Functional Enrichment Analysis.
Objective
This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein-protein interaction network.
Results
We used target proteins to create protein-protein interaction network (PPIN) and identified significant node and edge attributes of PPIN. We identified the cluster of proteins in the PPIN, which were used to identify enriched pathways. We identified closeness centrality and jaccard score as most important node and edge attribute of the PPIN respectively. The enriched pathways of various clusters were overlapped suggesting synergistic mechanism of action. The three pathways found to be common among three clusters were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.
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Posted 22 Sep, 2020
On 07 Oct, 2020
On 21 Sep, 2020
On 19 Sep, 2020
On 18 Sep, 2020
On 18 Sep, 2020
On 08 Sep, 2020
On 05 Sep, 2020
On 04 Sep, 2020
On 04 Sep, 2020
On 22 Jul, 2020
Received 19 Jul, 2020
Received 18 Jul, 2020
On 10 Jul, 2020
On 09 Jul, 2020
On 05 Jun, 2020
Invitations sent on 05 Jun, 2020
On 04 Jun, 2020
On 02 Jun, 2020
On 27 May, 2020
Network Pharmacology study of Curcuma longa L.: Potential Target Proteins and their Functional Enrichment Analysis.
Posted 22 Sep, 2020
On 07 Oct, 2020
On 21 Sep, 2020
On 19 Sep, 2020
On 18 Sep, 2020
On 18 Sep, 2020
On 08 Sep, 2020
On 05 Sep, 2020
On 04 Sep, 2020
On 04 Sep, 2020
On 22 Jul, 2020
Received 19 Jul, 2020
Received 18 Jul, 2020
On 10 Jul, 2020
On 09 Jul, 2020
On 05 Jun, 2020
Invitations sent on 05 Jun, 2020
On 04 Jun, 2020
On 02 Jun, 2020
On 27 May, 2020
Objective
This study’s primary goal is unraveling the mechanism of action of bioactives of Curcuma longa L. at the molecular level using protein-protein interaction network.
Results
We used target proteins to create protein-protein interaction network (PPIN) and identified significant node and edge attributes of PPIN. We identified the cluster of proteins in the PPIN, which were used to identify enriched pathways. We identified closeness centrality and jaccard score as most important node and edge attribute of the PPIN respectively. The enriched pathways of various clusters were overlapped suggesting synergistic mechanism of action. The three pathways found to be common among three clusters were Gonadotropin-releasing hormone receptor pathway, Endothelin signaling pathway, and Inflammation mediated by chemokine and cytokine signaling pathway.
Figure 1
Figure 2