This research paper investigates the optimization of radiation performance of a plasma-based bioconvective nanofluid integrated Magneto-hydrodynamic (MHD) micropump for radiative oncology. It addresses a literature gap by analysing the radiative impact of blood-based hybrid nanofluids in MHD micropumps. Three blood-based bio-convective radiating hybrid nanofluids – blood – Pt, blood – Au and blood - MWCNT are studied to understand their radiation behaviour in MHD pump while being employed as transportation medium. The investigation employs two non-dimensional parameters, namely Rd (Radiation number) and Ha (Hartmann number), to examine the fluid dynamics, magnetic characteristics, and electrical properties of the MHD micropump. The temperature gradient, velocity distribution, and pressure drop along the flow channel are examined within the specified range of Rd and Ha. Magnetic flux density (MFD) and electric flux intensity (EFI) are evaluated to understand nanoparticle behaviour during drug delivery and blood transportation. Findings highlight that MWCNT and Pt are the most efficient bioconvective nanoparticles for plasma transportation under high radiative conditions. MWCNT-based blood flow exhibits desirable characteristics, including sufficient intake pressure and minimal pressure drop. Coherence between radiation flux and electromagnetic flux reduces pumping power and ensures uniform heat dissipation for improved drug delivery. Au nanoparticles provide maximum magnetic flux density, even in highly radiative environments, making them suitable for applications like embedded chemotherapy or cell treatment. Au nanoparticles maintain moderate electrical flux intensity with a minimal drop, particularly at higher radiative environments influenced by the Radiation number. Conclusively, it has been identified that MWCNT and Au are superior nanofluids for advanced radiative oncological treatments. These nanofluids have the potential to enhance plasma transportation, thermal regulation, and aetilogical disease management. The present study provides significant findings on enhancing the radiation performance in MHD micropumps through utilization of blood-based hybrid nanofluids, thereby offering potential advantages to the domain of biomedical engineering.