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Research note
Bikash Medhi
PGIMER
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4017-641X
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Objective: Chloroquine is used as conventional drug therapy for the treatment of malaria. The existence of resistance for chloroquine shown among various species of Plasmodium leads to the search for more efficacious therapy to treat malaria. Probiotics (Lactobacillus casei) have been tried as add-on therapy with chloroquine. Probiotics are ingested microorganisms associated with a beneficial effect on humans and other species. The study was done to check the efficacy of probiotics as an add-on therapy along with conventional drug therapy (chloroquine) to treat malaria.
Results: Probiotics in combination with chloroquine showed complete suppression in parasitemia count. Representation of parasitemia count was done using mean ± SD. P<0.05 is considered significant. The results showed a reduction in parasitemia with probiotics treatment, which was further confirmed through histological observation of two major organs liver and spleen. Interestingly, further suppression of parasitemia and hemosiderosis was observed when probiotics were given along with chloroquine.
Keywords
Chloroquine, Probiotics, Malaria, Lactobacillus casei
Figure 1
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Figure 3
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- ARRIVEGuidelinesChecklist.docx
- Picture1suppl.jpg
Figure S1: Giemsa Stain slide of parasitemia on 4th day of treatment observed under 1000 X magnification.
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This preprint is under consideration at BMC Research Notes. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
Bikash Medhi
PGIMER
Corresponding Author
ORCiD: https://orcid.org/0000-0002-4017-641X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 19 Mar, 2021
No community comments so far
Reviewer #1 agreed
On 11 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 07 Mar, 2021
Submission checks complete
On 07 Mar, 2021
Editor invited
On 07 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: Chloroquine is used as conventional drug therapy for the treatment of malaria. The existence of resistance for chloroquine shown among various species of Plasmodium leads to the search for more efficacious therapy to treat malaria. Probiotics (Lactobacillus casei) have been tried as add-on therapy with chloroquine. Probiotics are ingested microorganisms associated with a beneficial effect on humans and other species. The study was done to check the efficacy of probiotics as an add-on therapy along with conventional drug therapy (chloroquine) to treat malaria.
Results: Probiotics in combination with chloroquine showed complete suppression in parasitemia count. Representation of parasitemia count was done using mean ± SD. P<0.05 is considered significant. The results showed a reduction in parasitemia with probiotics treatment, which was further confirmed through histological observation of two major organs liver and spleen. Interestingly, further suppression of parasitemia and hemosiderosis was observed when probiotics were given along with chloroquine.
Figure 1
Figure 2
Figure 3
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