Objective: Chloroquine is used as conventional drug therapy for the treatment of malaria. The existence of resistance for chloroquine shown among various species of Plasmodium leads to the search for more efficacious therapy to treat malaria. Probiotics (Lactobacillus casei) have been tried as add-on therapy with chloroquine. Probiotics are ingested microorganisms associated with a beneficial effect on humans and other species. The study was done to check the efficacy of probiotics as an add-on therapy along with conventional drug therapy (chloroquine) to treat malaria.
Results: Probiotics in combination with chloroquine showed complete suppression in parasitemia count. Representation of parasitemia count was done using mean ± SD. P<0.05 is considered significant. The results showed a reduction in parasitemia with probiotics treatment, which was further confirmed through histological observation of two major organs liver and spleen. Interestingly, further suppression of parasitemia and hemosiderosis was observed when probiotics were given along with chloroquine.
Figure 1
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This is a list of supplementary files associated with this preprint. Click to download.
Figure S1: Giemsa Stain slide of parasitemia on 4th day of treatment observed under 1000 X magnification.
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Posted 19 Mar, 2021
On 11 Mar, 2021
Invitations sent on 08 Mar, 2021
On 07 Mar, 2021
On 07 Mar, 2021
On 07 Mar, 2021
Posted 19 Mar, 2021
On 11 Mar, 2021
Invitations sent on 08 Mar, 2021
On 07 Mar, 2021
On 07 Mar, 2021
On 07 Mar, 2021
Objective: Chloroquine is used as conventional drug therapy for the treatment of malaria. The existence of resistance for chloroquine shown among various species of Plasmodium leads to the search for more efficacious therapy to treat malaria. Probiotics (Lactobacillus casei) have been tried as add-on therapy with chloroquine. Probiotics are ingested microorganisms associated with a beneficial effect on humans and other species. The study was done to check the efficacy of probiotics as an add-on therapy along with conventional drug therapy (chloroquine) to treat malaria.
Results: Probiotics in combination with chloroquine showed complete suppression in parasitemia count. Representation of parasitemia count was done using mean ± SD. P<0.05 is considered significant. The results showed a reduction in parasitemia with probiotics treatment, which was further confirmed through histological observation of two major organs liver and spleen. Interestingly, further suppression of parasitemia and hemosiderosis was observed when probiotics were given along with chloroquine.
Figure 1
Figure 2
Figure 3
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