Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.
Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.
Figure 1
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Posted 18 Mar, 2021
Invitations sent on 10 Mar, 2021
On 08 Mar, 2021
On 08 Mar, 2021
On 08 Mar, 2021
On 21 Feb, 2021
Posted 18 Mar, 2021
Invitations sent on 10 Mar, 2021
On 08 Mar, 2021
On 08 Mar, 2021
On 08 Mar, 2021
On 21 Feb, 2021
Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.
Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.
Figure 1
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