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Research note
Khadijeh Mirzaei
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7554-8551
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.
Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.
Keywords
MIND diet, metabolic dyslipidemia, Caveolin 1, obesity
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CURRENT STATUS: Under Review
Version 1
Posted 18 Mar, 2021
No community comments so far
Review #2 received
Received 06 May, 2021
Reviewer #2 agreed
On 21 Apr, 2021
Reviewer #1 agreed
On 18 Apr, 2021
Reviewers invited
Invitations sent on 10 Mar, 2021
Editor assigned
On 08 Mar, 2021
Submission checks complete
On 08 Mar, 2021
Editor invited
On 08 Mar, 2021
First submitted
On 21 Feb, 2021
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This preprint is under consideration at BMC Research Notes. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
Khadijeh Mirzaei
Tehran University of Medical Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7554-8551
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 18 Mar, 2021
No community comments so far
Review #2 received
Received 06 May, 2021
Reviewer #2 agreed
On 21 Apr, 2021
Reviewer #1 agreed
On 18 Apr, 2021
Reviewers invited
Invitations sent on 10 Mar, 2021
Editor assigned
On 08 Mar, 2021
Submission checks complete
On 08 Mar, 2021
Editor invited
On 08 Mar, 2021
First submitted
On 21 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: A higher incidence of metabolic dyslipidemia (MD) and its association with many diseases attracted considerable attention to its control. Caveolin 1 (CAV1) is a known gene associated with obesity. Today, a novel diet recognized as the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diet (MIND( is reported to have a positive effect on overall health. Hence, we aimed to investigate the interactions between CAV1 polymorphism and MIND diet on the MD in overweight and obese patients.
Results: Remarkably, there was a significant interaction between the MIND diet and CAV1 rs3807992 for dyslipidemia (β=-0.25±132, P=0.05) in the crude model. Whereby, subjects with dominant alleles had a lower risk of dyslipidemia and risk allele carriers with higher adherence to MIND diet may exhibit the lower dyslipidemia.This study presented the CAV1 gene as a possible genetic marker in recognizing people at higher risks for metabolic diseases. It also indicated that using the MIND diet may help in improving dyslipidemia through providing a probable interaction with CAV1 rs3807992 polymorphism.
Figure 1
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