Waste incineration is a process of full combustion reaction between waste and oxygen at high temperature. It is a new problem whether the special natural environmental conditions of Tibet Plateau, such as low air pressure, low oxygen content and low temperature, will affect the waste incineration in the plateau area. In this work, the influence of different parameters on MSW incineration efficiency and flue gas emission were investigated. The results showed that the temperatures exhibited a significant impact on the flue gas emission. Under the lower temperature, CO was determined to be the main pollutant. With the increase of temperature, NOx became the main pollutant. The optimal temperature range of flue gas emission was between 800ºC to 900ºC. A slight negative pressure in incinerator was benefit for incineration system safety and flue gas emissions. The optimal range was -50Pa to 0Pa. Lower oxygen content (3%-6%) in the incinerator affected the incineration efficiency and flue gas emission. Meanwhile, the high oxygen content had no obvious impact on the flue gas emission, but the cost increased and the service life of the incinerator was affected. The optimal oxygen content in the incinerator was controlled at 6%-8%. Furthermore, the air temperatures, pressures and oxygen content in the natural environment had no significant effect on MSW incineration process. Increasing the air volume would bring about the increase of N 2 in the incinerator. This work provides the basic data support for MSW incineration technology in plateau area.