Darier’s disease is a rare genetic condition caused by mutations of the ATP2A2 gene and characterized by hyperkeratotic red brown papules on the skin. While there is currently no cure for the disease, a recent study offers a unique look into the role of the skin microbiome that could guide researchers toward new ways of treating Darier’s disease. The team investigated the skin microbiome of 14 patients with Darier’s disease and their healthy matched controls, which was made possible by a newly founded German registry of patients with Darier’s disease. The team’s findings revealed distinct patterns linking inflammation, microbial dysbiosis, and malodor. The spread of inflammation due to specific bacteria strongly correlated with disease severity. Dysbiosis tied to imbalances in bacterial numbers showed strong associations with malodor intensity. And transcriptomic analyses connected barrier and immune response mechanisms of Darier’s disease to a dysbiotic microbiome. While more research involving a larger group of patients is needed to verify these associations, these findings offer valuable insight into Darier’s disease and how the microbiome could be a promising target of treatment.