Quantitative Structure property relationship for the anti-viral drugs: Remdesivir, Favipiravir, Ribavirin, Lopinavir, Ritonavir, Darunavir, Oseltamivir and Umifenovir through degree based topological descriptors are presented. This QSPR study provides the mathematical relationship between the phsyico-chemical properties and different topological descriptors. This study conducted a comprehensive analysis of the data derived from the various topological descriptors of antiviral drugs using a range of statistical parameters. It is further demonstrated that these topological descriptors are closely related to the physicochemical characteristics of the above-mentioned antiviral drugs. The statistical analysis may be useful to the pharmaceutical industry in predicting the properties of antiviral drugs without conducting experiments.