This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Short Report
Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak
Samer Singh
Institute of Medical Sciences, Banaras Hindu University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Various studies are underway to identify protective variables for the COVID-19 pandemic. We hypothesized that if indeed the Vitamin D levels would be protective in the European population, as recently proposed, the correlation would become more robust when the countries had passed the infection peak as on May 12, 2020, compared to April 8, 2020, when the majority had not. Comparative analysis of data from the mentioned stages indicated a significant increase in negative correlation of vitamin D levels with COVID-19 cases per million population in later stage (r(20): -0.5504; R2=0.3029; p-value: 0.0119 vs r(20): -0.4435; R2=0.1967; p-value: 0.0501) whereas the correlation with deaths per million population became insignificant (r(20): -0.3935; R2=0.1549; p-value: 0.0860 vs r(20): -0.4378; R2=0.1917; p-value: 0.0535). Considering divergence of vitamin D levels from the mean in subgroups, e.g. children, women, aged, dedicated exploratory studies with carefully chosen matched target groups is advisable.
Keywords
COVID-19, SARS-CoV-2, Correlation, Vitamin D, Europe
Figure 1
Due to technical limitations, the tables are only available as a download in the supplemental files section.
This is a list of supplementary files associated with this preprint. Click to download.
Rob
commented on 02 June, 2020
Arguably Sweden's decision not to implement a lockdown means its data are drawn from a different distribution from the data of the countries that did (all of the others as far as I can tell). Recalculating the 12 May vitamin D vs deaths per million results omitting the Swedish data yields r = -0.4688, R2 = 0.2197, and p-value 0.0429.
View 1 reply
samer singh
commented on 14 August, 2020
It is in press with details as under Singh S*, Kaur R, Singh R K. Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak. Aging Clin Exp Res. 2020 (in press); doi: 10.1007/s40520-020-01619-8
2 comments flagged for moderation
If you posted a comment and think it was mistakenly removed, please contact customer support at [email protected].
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 01 Jun, 2020
Community comments: 3
Metrics
Comments: 3
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
Learn more about our company.
This is a preprint. It has not completed peer review.
Short Report
Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak
Samer Singh
Institute of Medical Sciences, Banaras Hindu University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 01 Jun, 2020
Community comments: 3
Metrics
Comments: 3
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Various studies are underway to identify protective variables for the COVID-19 pandemic. We hypothesized that if indeed the Vitamin D levels would be protective in the European population, as recently proposed, the correlation would become more robust when the countries had passed the infection peak as on May 12, 2020, compared to April 8, 2020, when the majority had not. Comparative analysis of data from the mentioned stages indicated a significant increase in negative correlation of vitamin D levels with COVID-19 cases per million population in later stage (r(20): -0.5504; R2=0.3029; p-value: 0.0119 vs r(20): -0.4435; R2=0.1967; p-value: 0.0501) whereas the correlation with deaths per million population became insignificant (r(20): -0.3935; R2=0.1549; p-value: 0.0860 vs r(20): -0.4378; R2=0.1917; p-value: 0.0535). Considering divergence of vitamin D levels from the mean in subgroups, e.g. children, women, aged, dedicated exploratory studies with carefully chosen matched target groups is advisable.
Figure 1
Due to technical limitations, the tables are only available as a download in the supplemental files section.
Rob
commented on 02 June, 2020
Arguably Sweden's decision not to implement a lockdown means its data are drawn from a different distribution from the data of the countries that did (all of the others as far as I can tell). Recalculating the 12 May vitamin D vs deaths per million results omitting the Swedish data yields r = -0.4688, R2 = 0.2197, and p-value 0.0429.
View 1 reply
samer singh
replied on 02 June, 2020
Thanks, Rob for pointing this out. It makes the correlation better.
samer singh
commented on 14 August, 2020
It is in press with details as under Singh S*, Kaur R, Singh R K. Revisiting the role of vitamin D levels in the prevention of COVID-19 infection and mortality in European countries post infections peak. Aging Clin Exp Res. 2020 (in press); doi: 10.1007/s40520-020-01619-8
samer singh
replied on 02 June, 2020
Thanks, Rob for pointing this out. It makes the correlation better.