The peptide nesfatin-1, which is produced by cleavage of the protein Nucb2, acts as a hormone to control normal processes like food intake and storage. as well as pathological processes like neurodegeneration and cancer development. Another peptide, nesfatin-2, is also produced by cleavage of Nucb2, but the properties of nesfatin-2, as well as the nesfatin-1/2 complex, are unclear. To learn more, researchers recently examined these molecules with various predictive and analytical techniques. They found that nesfatin-1 is part of the intrinsically disordered protein (IDP) family. In contrast, nesfatin-2 and the nesfatin-1/2 complex are not IDPs, although they do have some intrinsically disordered regions. In addition, nesfatin-1 is generally ellipsoid or cylindrical in shape, while nesfatin-2 and the nesfatin-1/2 complex are more spherical. Zinc, an important trace metal in organisms, causes nesfatin-1 to become more structured and compact and to link to other molecules, while zinc destabilizes nesfatin-2 and nesfatin-1/2. Furthermore, the nesfatin-1/2 complex is not simply a sum of its parts; its properties are distinct from those of its component peptides. Although more studies are needed, the findings reveal the diverse properties of nesfatins and their complexes and lay a foundation for further research on the functions of these molecules.