Metagenomic sequencing is a powerful tool that gives researchers a comprehensive view of the genetic material in microbial ecosystems, but the reconstructed genomes are not always accurate, particularly if they include low-abundance sequences. This means metagenomic data cannot be used to characterize the genomic context of genes and functions and such location-specific data is critical when studying horizontal gene transfer via mobile genetic elements (MGEs). But researchers recently developed a new method to increase the accuracy of reconstruction and tested it against PacBio and short-read Illumina sequencing using technical replicates of diverse sample types. The new method, TELSeq (target-enriched long-read sequencing), was more sensitive than the other methods and revealed an extensive resistome profile made up of many low-abundance antibiotic resistance genes (ARGs), some of which had public health implications. Further, the long reads generated by TELSeq allowed researchers to identify many MGEs and cargo genes flanking these ARGs, meaning the ARGs could be moved between bacterial taxa via horizontal gene transfer. While more research is needed to validate the TELSeq workflow, this technique would allow researchers to view MGE-ARG pairings across an entire metagenome and has many potential applications ranging from public health to ecosystem surveillance.